KEGG   Neomonachus schauinslandi (Hawaiian monk seal): 110576620
Entry
110576620         CDS       T08474                                 
Symbol
TPH1
Name
(RefSeq) tryptophan 5-hydroxylase 1
  KO
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]
Organism
nsu  Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu00380  Tryptophan metabolism
nsu00790  Folate biosynthesis
nsu01100  Metabolic pathways
nsu04726  Serotonergic synapse
Module
nsu_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
Brite
KEGG Orthology (KO) [BR:nsu00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    110576620 (TPH1)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    110576620 (TPH1)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    110576620 (TPH1)
Enzymes [BR:nsu01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4  tryptophan 5-monooxygenase
     110576620 (TPH1)
SSDB
Motif
Pfam: Biopterin_H ACT TH_ACT ACT_4 zf-C2HE DUF5370 DUF262
Other DBs
NCBI-GeneID: 110576620
NCBI-ProteinID: XP_021541508
EnsemblRapid: ENSNSCG00000020395
UniProt: A0A2Y9GQE3
LinkDB
Position
11:39399940..39420024
AA seq 444 aa
MIEDNKENKDHSLERGRATLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNPPDSFTVKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHSLSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRQPSI
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgattgaagacaataaggaaaataaagaccattccttagaaagaggaagagcaactctc
attttttccttaaagaatgaagttggtggacttataaaagcactgaaaatcttccaggag
aagcatgtgaacctgttacatattgagtcccgaaaatcaaagagaagaaactcagaattt
gagatttttgttgactgtgatatcaacagagaacaattgaatgatatttttcatctgttg
aagtcccatactaacgttctctctgtgaatccaccagacagttttactgtgaaggaagat
ggtatggaaactgttccgtggtttccaaagaagatttctgacctggaccattgtgccaac
agagttctgatgtatggttctgaactggatgcagatcatcctggcttcaaagacaatgtc
taccgtaaaagacggaagtattttgcagacttggctatgaactataaacatggagacccc
attcccaaggttgaattcactgaagaggagattaagacctggggaactgtgttccaagag
ctcaacaaactttacccaacccatgcctgcagagagtatctcaaaaacttacctttgctt
tctaaatattgtgggtaccgggaagataatatcccacaattggaagatgtctcaaacttt
ttaaaagagcgcacgggtttttccatccgtcccgtggctggttacttatcaccaagagat
ttcttatcaggtttagccttccgggtttttcactgcacacagtacgtgagacacagttca
gaccctctctataccccagagccagatacttgccatgaactcttaggtcacgtccccctt
ttggctgaacctagttttgcgcagttctcccaggaaattggcctggcttcccttggagct
tcagaggaggctgttcaaaaactggcaacgtgctactttttcactgtggagtttggtctc
tgtaaacaagatgggcagttgcgagtctttggtgctggattactttcttctatcagtgaa
cttaagcattcactttctggacatgccaaagtaaagccctttgatcccaagattacctgc
aaacaggaatgtctcatcacaacttttcaggatgtctactttgtatctgaaagctttgaa
gatgcaaaggagaagatgagagaatttaccaaaacaattaagcgtccatttggagtgaag
tataatccatacacacggagtattcagatcttgaaagacaccaagagcataaccagtgcc
atgaatgagctgcagcatgatctcgatgtcgtcagtgatgcccttgcgaaggtcagcaga
cagccaagcatctga

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