Neogale vison (American mink): 122900048 Help Entry 122900048         CDS       T08764                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism nvs  Neogale vison (American mink) Pathway nvs01521   EGFR tyrosine kinase inhibitor resistance nvs04151   PI3K-Akt signaling pathway nvs04217   Necroptosis nvs04380   Osteoclast differentiation nvs04550   Signaling pathways regulating pluripotency of stem cells nvs04620   Toll-like receptor signaling pathway nvs04621   NOD-like receptor signaling pathway nvs04630   JAK-STAT signaling pathway nvs04658   Th1 and Th2 cell differentiation nvs04659   Th17 cell differentiation nvs05140   Leishmaniasis nvs05145   Toxoplasmosis nvs05152   Tuberculosis nvs05160   Hepatitis C nvs05161   Hepatitis B nvs05162   Measles nvs05163   Human cytomegalovirus infection nvs05164   Influenza A nvs05165   Human papillomavirus infection nvs05166   Human T-cell leukemia virus 1 infection nvs05167   Kaposi sarcoma-associated herpesvirus infection nvs05168   Herpes simplex virus 1 infection nvs05169   Epstein-Barr virus infection nvs05171   Coronavirus disease - COVID-19 nvs05200   Pathways in cancer nvs05203   Viral carcinogenesis nvs05212   Pancreatic cancer nvs05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:nvs00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     122900048 (JAK1)    04151 PI3K-Akt signaling pathway     122900048 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     122900048 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     122900048 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     122900048 (JAK1)    04621 NOD-like receptor signaling pathway     122900048 (JAK1)    04658 Th1 and Th2 cell differentiation     122900048 (JAK1)    04659 Th17 cell differentiation     122900048 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     122900048 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     122900048 (JAK1)    05203 Viral carcinogenesis     122900048 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     122900048 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     122900048 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     122900048 (JAK1)    05161 Hepatitis B     122900048 (JAK1)    05160 Hepatitis C     122900048 (JAK1)    05171 Coronavirus disease - COVID-19     122900048 (JAK1)    05164 Influenza A     122900048 (JAK1)    05162 Measles     122900048 (JAK1)    05168 Herpes simplex virus 1 infection     122900048 (JAK1)    05163 Human cytomegalovirus infection     122900048 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     122900048 (JAK1)    05169 Epstein-Barr virus infection     122900048 (JAK1)    05165 Human papillomavirus infection     122900048 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     122900048 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     122900048 (JAK1)    05140 Leishmaniasis     122900048 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     122900048 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:nvs01001]     122900048 (JAK1) Enzymes [BR:nvs01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      122900048 (JAK1) Protein kinases [BR:nvs01001]  Non-receptor tyrosine kinases   JAK family [OT]    122900048 (JAK1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  122900048 NCBI-ProteinID:  XP_044094312 LinkDB All DBs Position 2:complement(53609774..53735166) Genome browser AA seq 1153 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLRLGSGEYTAEEI CIRAAQECCISPLCHNLFALYDENSKLWYAPNRAITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHPNDSGNVLYYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLENKHKKDEEKNKTR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLIDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGT LVDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSERKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD YSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPLHCPDEVYQLMRKCWEFQPSNRTT FQNLIEGFEALLK NT seq 3462 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctctaagaagacggaggtgaatctggaggcccccgagccaggagtggaagtgctcttc tatctttctgatagggagcccctccggctgggcagcggagagtacactgcggaggagatc tgcatcagggctgcgcaggaatgctgtatctctcccctgtgtcacaacctctttgccctg tatgatgagaacagcaagctctggtatgccccgaatcgcgccatcactgttgacgacaag acatccctccggctccactaccggatgaggttctatttcaccaactggcatgggaccaat gataatgagcagtctgtatggcgacattctccaaagaagcagaaaaatggctatgagaaa aaaaaagtcccagatgcaacccctctccttgatgccagttctttggaatatctgtttgct cagggacagtatgatttggtcaaatgtctggctcccattcgagaccccaagaccgagcaa gatgggcatgatatcgagaacgagtgtctgggaatggctgtcctggccatctcccactac gccatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaggatttcctgaaggaatttaacaacaagactatttgtgacagcagt gtatctactcatgacctaaaggtgaagtacctggccaccttggaaacactgacaaaacat tatggcgcagaaatatttgagacttccatgttactgatttcttcagaaaatgagatgaat tggtttcatccaaacgacagtggaaacgttctctactatgaagtaatggtaactggaaat cttggaatccagtggagacagaaaccaaatgttgttcctgttgaaaaggaaaaaaacaaa ctgaaacggaaaaaactggaaaataaacacaagaaggatgaggagaaaaacaaaacccgg gaagagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtct gtggtcagcatcaataagcaggacaacaaaaaaatggaactgaagctctcgtcccatgaa gaggccttgtcctttgtgtccctgatagatggctacttccggctcacagcagatgcccat cattacctctgcaccgatgtggctcccccattgatcgtccacaacatacagaatggttgt cacggtccaatctgcacggaatatgccatcaataagttgcggcaagaaggaagcgaggag gggatgtatgtgctgaggtggagctgtaccgactttgataatatcctcatgacggtcacc tgctttgagaaatctgaggtgctgggtggccagaagcagttcaagaactttcagatcgaa gtgcagaagggccgctatagcctgcacggctcagaccgcagcttccccagcctgggggac ctgatgagccacctcaagaagcagatcctccgcacggacaacatcagcttcgttctgaag cgctgctgccagcccaagccccgagagatctccaatctgctggtggctacgaagaaagcc caggagtggcagcctgtctaccccatgagccagctgagttttgaccggatcctcaagaaa gacatcgtgcaaggtgagcatctcgggagaggcacacggactcacatctactccggcacc ctggtggattacaaggatgacgaaggaacttccgaagagaagagaataaaagtgatcctc aaagtcttagaccccagccacagggacatttctctggccttctttgaagcagccagcatg atgaggcaggtctcccacaaacacatcgtgtacctctatggtgtctgtgttcgagatgta gagaatatcatggtggaggagtttgtggaaggggggcccctggatctcttcatgcaccgg aaaagcgatgtcctcaccacaccatggaagttcaaagttgccaaacagctagccagcgcc ctgagttacttggaggataaagacctggtccatggaaacgtgtgcacgaaaaaccttctc ctggcccgtgagggcattgacagcgagtgtggcccgttcatcaagctcagtgaccctggc atccccatcaccgtgctgtccaggcaagagtgcatagaacgaatcccatggattgctccc gagtgtgttgaagactccaagaacctgagtgtggctgctgacaaatggagctttggaacc acactctgggaaatctgctacaatggcgagatccctctgaaagacaagaccctgattgag aaagagagattctacgaaagccggtgccggccagtgacaccatcttgtaaggagctggct gacctcatgacacgctgcatgaactatgaccccaaccagagacccttcttccgagccatc atgagagacatcaacaaactagaagagcagaatccagacattgtttctgaaagaaagccg gcaaccgaagtagatcccacacattttgaaaagcggttcttgaagaggatccgtgacttg ggagagggccactttgggaaggttgagctctgcaggtatgaccctgagggggacaatacc ggggagcaagtggcggtgaagtccctgaagcccgagagtggaggcaaccacatagctgat ctgaagaaggaaattgaaatcctaaggaacctctatcacgagaacattgtgaagtacaaa ggcatctgtacggaagacggaggaaatggtattaagctcatcatggaatttctgccttca ggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcaatta aaatacgctgttcagatttgtaaggggatggactatctgggttctcggcagtatgttcac cgggacttggcagcaagaaacgtcctcgttgagagtgagcaccaagtgaaaattggagac tttggtttgaccaaagcaattgaaactgacaaagagtactacaccgtcaaggatgatcgg gacagccctgtgttttggtatgctcccgaatgtttaattcagtgtaaattttacatcgcc tctgatgtctggtcatttggagtgactctgcatgaattgcttacttactgtgactcagat tacagccccatggcgttgttcctgaaaatgataggcccaactcatggccagatgacagtc acaagacttgtgaatacattaaaagaaggaaaacgtttgccttgtccacttcactgtcca gatgaggtttatcaacttatgagaaaatgctgggagttccaaccatccaatcggacaact tttcagaaccttatcgaaggatttgaagcacttttaaaataa

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