Ochotona princeps (American pika): 101528674 Help Entry 101528674         CDS       T07609                                  Symbol ADCY2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism opi  Ochotona princeps (American pika) Pathway opi00230   Purine metabolism opi01100   Metabolic pathways opi01522   Endocrine resistance opi04015   Rap1 signaling pathway opi04020   Calcium signaling pathway opi04022   cGMP-PKG signaling pathway opi04024   cAMP signaling pathway opi04062   Chemokine signaling pathway opi04072   Phospholipase D signaling pathway opi04114   Oocyte meiosis opi04211   Longevity regulating pathway opi04213   Longevity regulating pathway - multiple species opi04261   Adrenergic signaling in cardiomyocytes opi04270   Vascular smooth muscle contraction opi04371   Apelin signaling pathway opi04540   Gap junction opi04611   Platelet activation opi04713   Circadian entrainment opi04714   Thermogenesis opi04723   Retrograde endocannabinoid signaling opi04724   Glutamatergic synapse opi04725   Cholinergic synapse opi04727   GABAergic synapse opi04750   Inflammatory mediator regulation of TRP channels opi04911   Insulin secretion opi04912   GnRH signaling pathway opi04913   Ovarian steroidogenesis opi04914   Progesterone-mediated oocyte maturation opi04915   Estrogen signaling pathway opi04916   Melanogenesis opi04918   Thyroid hormone synthesis opi04921   Oxytocin signaling pathway opi04922   Glucagon signaling pathway opi04923   Regulation of lipolysis in adipocytes opi04925   Aldosterone synthesis and secretion opi04926   Relaxin signaling pathway opi04927   Cortisol synthesis and secretion opi04928   Parathyroid hormone synthesis, secretion and action opi04934   Cushing syndrome opi04935   Growth hormone synthesis, secretion and action opi04970   Salivary secretion opi04971   Gastric acid secretion opi04972   Pancreatic secretion opi04976   Bile secretion opi05032   Morphine addiction opi05163   Human cytomegalovirus infection opi05166   Human T-cell leukemia virus 1 infection opi05200   Pathways in cancer opi05207   Chemical carcinogenesis - receptor activation opi05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:opi00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     101528674 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     101528674 (ADCY2)    04371 Apelin signaling pathway     101528674 (ADCY2)    04020 Calcium signaling pathway     101528674 (ADCY2)    04072 Phospholipase D signaling pathway     101528674 (ADCY2)    04024 cAMP signaling pathway     101528674 (ADCY2)    04022 cGMP-PKG signaling pathway     101528674 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     101528674 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     101528674 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101528674 (ADCY2)    04062 Chemokine signaling pathway     101528674 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     101528674 (ADCY2)    04922 Glucagon signaling pathway     101528674 (ADCY2)    04923 Regulation of lipolysis in adipocytes     101528674 (ADCY2)    04912 GnRH signaling pathway     101528674 (ADCY2)    04913 Ovarian steroidogenesis     101528674 (ADCY2)    04915 Estrogen signaling pathway     101528674 (ADCY2)    04914 Progesterone-mediated oocyte maturation     101528674 (ADCY2)    04921 Oxytocin signaling pathway     101528674 (ADCY2)    04926 Relaxin signaling pathway     101528674 (ADCY2)    04935 Growth hormone synthesis, secretion and action     101528674 (ADCY2)    04918 Thyroid hormone synthesis     101528674 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     101528674 (ADCY2)    04916 Melanogenesis     101528674 (ADCY2)    04925 Aldosterone synthesis and secretion     101528674 (ADCY2)    04927 Cortisol synthesis and secretion     101528674 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     101528674 (ADCY2)    04270 Vascular smooth muscle contraction     101528674 (ADCY2)   09154 Digestive system    04970 Salivary secretion     101528674 (ADCY2)    04971 Gastric acid secretion     101528674 (ADCY2)    04972 Pancreatic secretion     101528674 (ADCY2)    04976 Bile secretion     101528674 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     101528674 (ADCY2)    04727 GABAergic synapse     101528674 (ADCY2)    04725 Cholinergic synapse     101528674 (ADCY2)    04723 Retrograde endocannabinoid signaling     101528674 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     101528674 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     101528674 (ADCY2)    04213 Longevity regulating pathway - multiple species     101528674 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     101528674 (ADCY2)    04714 Thermogenesis     101528674 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101528674 (ADCY2)    05207 Chemical carcinogenesis - receptor activation     101528674 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101528674 (ADCY2)    05163 Human cytomegalovirus infection     101528674 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     101528674 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     101528674 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101528674 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101528674 (ADCY2) Enzymes [BR:opi01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      101528674 (ADCY2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  101528674 NCBI-ProteinID:  XP_004597949 LinkDB All DBs Position 11:complement(35523869..35841809) Genome browser AA seq 1051 aa AA seqDB search MSQQHPLIVFLLLIVMGTCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAVFILVCVE AVFKKLLRLFSLVIWICLVAMGFLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAI IASVLTSSSHTVVLSVCLSAAPGAKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQT YQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGHMENTNNFH NLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGD CYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQ KWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVK TYFVINPKGERRSPHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTEN GKISTMDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRIS LLFYNKILEKEYRATALPAFKYYVTCACLIFFCIFVVQILVLPKTSILGISFGAAFLSLA LILFVCFAGQLLQCSKKASGSLMWLLKSSGIIANRPWPRISLTVITTAIILTMAVFNMFF LSDSEGIILPTVNTSNTSFPASSNQAAILRAQNLFFLPYFIYSCILGLIACSVFLRINYE LKMLIMMVALVLYNILLLHTHAHVLDDYSQVLFERPGIWKDLKTMGSVSLSIFFVTLLVL GRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYH QSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKT IGSTYMAATGLSAVPSQEHAQEPERQYMHIGTMVEFAFALVAKLDAINKHSFNDFKLRVG INHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCR GIINVKGKGDLKTYFVNTEMSRSLSQSNVAS NT seq 3156 nt NT seq  +upstreamnt  +downstreamnt atgagccagcagcacccgctcatcgtcttcctactgctcatcgtgatgggcacctgcctt gccctcctcgccgtcttcttcgcgctcgggctggaagtggaagaccatgtcgcattttta atcacagtgcccacggctctggccatcttcttcgccgttttcatcctggtgtgtgtggag gccgtgtttaagaagctgctgaggctcttctccctggtgatctggatctgcctcgtggcc atggggttcctcttcatgtgctttggtggcaccgtctctccctgggaccaggtgtctttc ttcctcttcatcatcttcgtggtgtacaccatgctgcccttcaacatgcgagatgccatc atcgccagcgtccttacctcctcttcccataccgttgtattgagtgtctgcctgtctgca gctccgggggccaaggaacacctggtctggcagattctggccaacgtgatcatcttcatc tgtgggaacctggcaggagcctaccacaagcatctcatggagcttgctctacagcagact taccaggacacctgcaactgcatcaaatcccggatcaagctggaattcgagaagcgtcag caggagcggctgctgctgtccttgctaccagctcacattgcgatggaaatgaaggcagag atcatccagagactgcaaggccccaaggcaggtcacatggagaacacaaacaacttccac aacctatatgtcaagcgacacaccaatgtgagtatcttatatgctgacattgtggggttc acccgccttgccagtgactgctccccaggagaactggtccacatgttgaatgagctcttc ggaaagtttgatcagattgcaaaggagaatgaatgcatgagaattaaaattttaggtgac tgctattactgcgtgtctggacttcccatctctctgcccaaccatgccaagaactgtgtg aaaatggggctggacatgtgtgaagctattaagaaagtgagggacgccactggagttgac atcaacatgcgtgtgggagtgcattccgggaatgtgctgtgtggcgttattggtctgcag aaatggcagtacgatgtgtggtcacatgatgtcactctggccaatcacatggaggctgga ggagtccctggacgtgtccacatttcttcagtcaccctggagcacctgaacggagcctac aaggtggaggagggagacggtgacatcagagacccatatttaaaacagcacttggtgaaa acctacttcgtgatcaacccaaagggagagcggcggagtcctcatctcttcaggcctcgc cacaccctcgatggagcaaagatgagggcatctgtccgcatgacccggtacctggaatct tggggggcagccaaaccctttgcacacctgcaccacagagacagcatgaccacagagaat gggaagatcagcaccatggatgtaccaatgggtcagcataattttcagaatcgcacctta agaaccaagtcacaaaagaaaagatttgaagaagaattgaatgaaaggatgattcaagca attgatggaattaatgcacagaagcaatggctcaagtctgaagatattcaaagaatctca ctgcttttctataacaaaatactggaaaaagaataccgagccactgctctgccagccttc aagtattatgtgacttgtgcatgcctcatattcttctgcatcttcgtcgtgcagatcctc gtattgccaaagacatccatccttgggatttcttttggagccgcatttctctcgcttgcc ttgatccttttcgtctgctttgctggacagcttttgcaatgtagcaaaaaagcttcaggc tccctcatgtggctgctgaaatcctcaggcatcattgccaaccggccctggccacggatc tccctcacggtcatcaccacagccatcatcttgaccatggctgtgtttaacatgtttttc ctgagtgactcagagggaataatccttccaactgtcaatacttcaaacacaagttttcct gcctcaagtaatcaggcagcgattctacgtgcacaaaatttgtttttcctcccgtacttt atctacagctgcattctgggcttgatagcctgctccgttttcctgcggataaattatgag ttgaaaatgttgatcatgatggtggccttggtgctctacaacatcctgctgctccacacc catgcccacgtcctggatgactacagccaggtcttgtttgagaggccaggcatttggaaa gacctgaagaccatgggctcagtatctctctccatctttttcgtcactctgctggtcctg ggaagacagaatgaatattactgtaggttggacttcttgtggaagaacaagttcaaaaaa gagcgggaggagatagaaaccatggagaacctgaaccgcgtgctgctggagaacgtgctt ccggcccacgtggctgagcacttcctggcccggagcctgaaaaacgaggagctgtaccac caatcctacgactgtgtctgcgtcatgtttgcctccatcccagatttcaaagaattctac acggagtcggatgtgaacaaggagggcctggagtgcctgcggctccttaacgagatcatc gctgactttgatgatctgctgtccaagcccaaattcagtggagttgaaaagatcaagacc attggcagcacgtacatggcagcgacaggactgagtgcagtgcccagccaggagcatgct caggagcccgagcggcagtacatgcacatcggtaccatggtggagtttgcctttgccctc gttgccaaactggatgccatcaacaaacactccttcaacgacttcaagctgcgagtagga attaaccacggccctgtgatagctggcgtcatcggagcccagaagccgcaatatgacatc tggggcaacacagtcaacgtggccagcaggatggacagcaccggggtcctggacaagatc caggtcaccgaggagaccagcctcatcctgcagacgctgggttacacgtgcacgtgccgc gggatcatcaacgtgaaggggaagggggacctgaagacgtactttgtgaacacagaaatg tcacgatccctttcccagagcaacgtggcatcctga

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