Oncorhynchus tshawytscha (Chinook salmon): 112256921
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Entry
112256921 CDS
T05605
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
otw
Oncorhynchus tshawytscha (Chinook salmon)
Pathway
otw00270
Cysteine and methionine metabolism
otw00480
Glutathione metabolism
otw01100
Metabolic pathways
otw01240
Biosynthesis of cofactors
otw04216
Ferroptosis
Module
otw_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
otw00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
112256921
09106 Metabolism of other amino acids
00480 Glutathione metabolism
112256921
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
112256921
Enzymes [BR:
otw01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
112256921
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Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
112256921
NCBI-ProteinID:
XP_024286277
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Position
LG01:76192819..76232316
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AA seq
629 aa
AA seq
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MGLLSQGSPLNWEETKKYADHVRMHGIVQFLNIYNKVKERQKDVLLWGDEVEYMLIEMDE
KNEKVRLVLNGGEVLETLQDKGEKANPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMGKRRREASSVLNKNETLATITSFPRLGCPGFTQPEYKPTPVEKGVSKSLFFPDEAI
NGHPRFSTLTRNIRHRRGEKVVINVPIFKDKCTPSPFVEKFPEDDGEAARAALPDHIYMD
AMGFGMGNCCLQVTFQACSIEEARYLYDQLATFCPIVMALSAASPFYRGYVSDIDCRWGV
ISASVDDRTGEERGLEPLKSNKFRILKSRYDSIDSYLSSCGDKYNDIDLTIDEEINKQLL
DAGIDKLLAQHIAHLFIRDPLSLFEEKIHLDDENESDHFENLQSTNWQTMRFKPPPPNSD
IGWRVEFRPMEVQLTDFENSAYVVFIVLLTRVILSYKLDFLIPLSKVDENMKVAQERNAV
QEGMFYFRKDIYKGCNPVLDSSSAAQNGLDSEGDNEYILMSIDTIINGKEGVFQGLIPIL
NCYLENMEVDVDTRCTILNYLKLIKRRASGELMTIAKWMREFVDKHTQYKQDSVITDKIN
YDLLRKCDSISKGEERCPELFGDPVNRGK
NT seq
1890 nt
NT seq
+upstream
nt +downstream
nt
atgggtttgctgtcacaagggtcaccgctcaactgggaagaaaccaaaaagtatgcagac
catgtcaggatgcatggcatcgttcagtttctcaacatctataacaaggtgaaagaacga
cagaaggatgtattgttatggggcgatgaggtggaatacatgttgattgaaatggatgag
aaaaatgaaaaggttcgtcttgttctcaatggtggggaggttttggaaacccttcaagac
aaaggtgaaaaggcaaaccccaaccatcctaccctttggaggccagagtatggcagctac
atgatcgaagggactccggggcagccatacggtgggacgatgtcagagttcaacacagtg
gaggacaacatgggaaagaggaggcgagaggcctcatctgtgctgaataagaatgaaacc
cttgccaccatcacatcattcccaaggttaggttgtccaggcttcacccagccagagtac
aaaccaacacctgttgaaaaaggagtgtccaaatcactgttcttcccagatgaagccata
aacggacacccaagattcagcaccctgaccagaaacattcgtcacagaagaggagagaag
gtagtgatcaacgtacccatctttaaagacaagtgcactccatctccatttgtggagaag
tttccggaggatgatggggaagccgccagagcagctctccctgatcacatctacatggat
gccatgggcttcggaatgggcaactgctgtcttcaggtgacattccaagcttgcagcatt
gaagaggcgaggtacctttatgaccaactagcaacattctgccccatagtgatggccctc
agtgctgcttcgccgttttacagaggctatgtgtcagacattgattgtcgctggggagtt
atttctgcctcggtggatgacaggaccggggaagagagagggctggagcctttgaaaagc
aacaaatttcgaatcttgaaatcaagatatgattcaatcgacagctacctctccagttgt
ggcgataagtacaatgacatagatctgacaatagacgaggagatcaacaaacagttgctg
gatgcagggattgacaaactgctggcccaacacatagcccatcttttcatccgggatccg
ctgtcactctttgaggagaaaattcacctggatgatgaaaacgagtcagatcactttgag
aatctgcagtcaaccaactggcagacaatgaggttcaaacctcctcctccaaactcggac
attggatggcgagttgagttccgccccatggaggtgcaacttaccgattttgaaaactct
gcttacgttgttttcatcgtcctgctcaccagggttatcctgtcctataaactagacttt
ctcatccccttgtcaaaggttgacgaaaacatgaaagtggcccaggaaagaaatgcagtc
caagagggcatgttttacttccggaaggacatctataaaggctgtaaccctgtcctcgat
agctcctcagcggcccagaacggcttggacagtgagggtgacaatgagtacatactgatg
agcattgacacaatcatcaatggaaaggaaggagtttttcaagggctgataccaatcctt
aactgctacctggaaaacatggaggtggacgtcgatacaagatgcaccatcctgaactac
ctgaagctcatcaagagacgcgcctcaggtgaactgatgaccatagcaaagtggatgagg
gagtttgtcgacaagcacactcaatacaagcaagacagcgtaataactgacaaaataaac
tacgacttactccgcaagtgtgacagtatctcaaaaggagaggagcgatgcccagaactt
tttggagacccagtcaataggggcaaataa
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