KEGG   Pteropus alecto (black flying fox): 102888845
Entry
102888845         CDS       T02993                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
pale  Pteropus alecto (black flying fox)
Pathway
pale01522  Endocrine resistance
pale04010  MAPK signaling pathway
pale04015  Rap1 signaling pathway
pale04068  FoxO signaling pathway
pale04071  Sphingolipid signaling pathway
pale04114  Oocyte meiosis
pale04148  Efferocytosis
pale04218  Cellular senescence
pale04261  Adrenergic signaling in cardiomyocytes
pale04370  VEGF signaling pathway
pale04380  Osteoclast differentiation
pale04550  Signaling pathways regulating pluripotency of stem cells
pale04611  Platelet activation
pale04613  Neutrophil extracellular trap formation
pale04620  Toll-like receptor signaling pathway
pale04621  NOD-like receptor signaling pathway
pale04622  RIG-I-like receptor signaling pathway
pale04625  C-type lectin receptor signaling pathway
pale04657  IL-17 signaling pathway
pale04658  Th1 and Th2 cell differentiation
pale04659  Th17 cell differentiation
pale04660  T cell receptor signaling pathway
pale04664  Fc epsilon RI signaling pathway
pale04668  TNF signaling pathway
pale04670  Leukocyte transendothelial migration
pale04714  Thermogenesis
pale04722  Neurotrophin signaling pathway
pale04723  Retrograde endocannabinoid signaling
pale04728  Dopaminergic synapse
pale04750  Inflammatory mediator regulation of TRP channels
pale04912  GnRH signaling pathway
pale04914  Progesterone-mediated oocyte maturation
pale04917  Prolactin signaling pathway
pale04926  Relaxin signaling pathway
pale04932  Non-alcoholic fatty liver disease
pale04933  AGE-RAGE signaling pathway in diabetic complications
pale04935  Growth hormone synthesis, secretion and action
pale04936  Alcoholic liver disease
pale05014  Amyotrophic lateral sclerosis
pale05020  Prion disease
pale05022  Pathways of neurodegeneration - multiple diseases
pale05132  Salmonella infection
pale05133  Pertussis
pale05135  Yersinia infection
pale05140  Leishmaniasis
pale05142  Chagas disease
pale05145  Toxoplasmosis
pale05152  Tuberculosis
pale05161  Hepatitis B
pale05163  Human cytomegalovirus infection
pale05167  Kaposi sarcoma-associated herpesvirus infection
pale05169  Epstein-Barr virus infection
pale05170  Human immunodeficiency virus 1 infection
pale05171  Coronavirus disease - COVID-19
pale05205  Proteoglycans in cancer
pale05208  Chemical carcinogenesis - reactive oxygen species
pale05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pale05415  Diabetic cardiomyopathy
pale05417  Lipid and atherosclerosis
pale05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pale00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102888845 (MAPK12)
   04015 Rap1 signaling pathway
    102888845 (MAPK12)
   04370 VEGF signaling pathway
    102888845 (MAPK12)
   04668 TNF signaling pathway
    102888845 (MAPK12)
   04068 FoxO signaling pathway
    102888845 (MAPK12)
   04071 Sphingolipid signaling pathway
    102888845 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    102888845 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102888845 (MAPK12)
   04218 Cellular senescence
    102888845 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    102888845 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102888845 (MAPK12)
   04613 Neutrophil extracellular trap formation
    102888845 (MAPK12)
   04620 Toll-like receptor signaling pathway
    102888845 (MAPK12)
   04621 NOD-like receptor signaling pathway
    102888845 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    102888845 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    102888845 (MAPK12)
   04660 T cell receptor signaling pathway
    102888845 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    102888845 (MAPK12)
   04659 Th17 cell differentiation
    102888845 (MAPK12)
   04657 IL-17 signaling pathway
    102888845 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    102888845 (MAPK12)
   04670 Leukocyte transendothelial migration
    102888845 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    102888845 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    102888845 (MAPK12)
   04917 Prolactin signaling pathway
    102888845 (MAPK12)
   04926 Relaxin signaling pathway
    102888845 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    102888845 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102888845 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    102888845 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    102888845 (MAPK12)
   04722 Neurotrophin signaling pathway
    102888845 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102888845 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102888845 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    102888845 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    102888845 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    102888845 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102888845 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102888845 (MAPK12)
   05161 Hepatitis B
    102888845 (MAPK12)
   05171 Coronavirus disease - COVID-19
    102888845 (MAPK12)
   05163 Human cytomegalovirus infection
    102888845 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102888845 (MAPK12)
   05169 Epstein-Barr virus infection
    102888845 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102888845 (MAPK12)
   05135 Yersinia infection
    102888845 (MAPK12)
   05133 Pertussis
    102888845 (MAPK12)
   05152 Tuberculosis
    102888845 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102888845 (MAPK12)
   05140 Leishmaniasis
    102888845 (MAPK12)
   05142 Chagas disease
    102888845 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    102888845 (MAPK12)
   05020 Prion disease
    102888845 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    102888845 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102888845 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    102888845 (MAPK12)
   05415 Diabetic cardiomyopathy
    102888845 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    102888845 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    102888845 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102888845 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    102888845 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pale01001]
    102888845 (MAPK12)
Enzymes [BR:pale01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     102888845 (MAPK12)
Protein kinases [BR:pale01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   102888845 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 102888845
NCBI-ProteinID: XP_024906817
LinkDB
Position
Unknown
AA seq 267 aa
MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLSEDRIQFLVYQMLKG
LKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNW
MHYTQTVDVWSAGCIMAEMITGKTLFKGNDHLDQLKEILKVTGTPPDEFVQRLQSADAKD
YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAERRVTAAEALTHPYFESLHDTEDE
PEAQKYDESFDDVDRTLDEWKCRRSPS
NT seq 804 nt   +upstreamnt  +downstreamnt
atgcgccacgagaacgtgatcgggctgctggacgtgttcactcctgatgagaccctggat
gatttcacagacttctacctggtcatgccgttcatgggcacggacctgggcaagctcatg
aagcacgagaagctgagtgaggaccggatccagttccttgtctaccagatgctgaagggg
ctgaagtacatccacgctgctggtgtcatccacagggacctgaagccgggcaatttggcc
gtgaacgaggactgtgagctgaagatcctggacttcggcctagccaggcaggcagacagc
gagatgactggttatgtggtgacccggtggtaccgggcacctgaggtcatcttgaattgg
atgcactacacgcagacggtggacgtctggtcagcgggctgcatcatggcagagatgatc
acagggaagactctgttcaagggcaatgaccacctggaccagctgaaggagatcttgaag
gtgacggggacaccgccggatgagttcgtgcagaggttgcagagcgccgatgccaaggac
tacatgaagggcctgcctgagctggagaagaaggattttgcctccatcctgaccaacgca
agccctctggccgtgaacctcctggaaaaaatgctggtgctggatgcggagcggcgggtg
acggcagccgaggcgctcacccacccctacttcgagtcactgcacgacacggaggatgag
cccgaggcccagaaatatgacgagtcctttgatgacgtggaccgcacgctggacgagtgg
aagtgccgccgctcaccctcttga

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