KEGG   PATHWAY: hsa00040
Entry
hsa00040                    Pathway                                
Name
Pentose and glucuronate interconversions - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
Pathway map
hsa00040  Pentose and glucuronate interconversions
hsa00040

Module
hsa_M00014  Glucuronate pathway (uronate pathway) [PATH:hsa00040]
Drug
D01805  Aceglatone (JAN/INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
10327  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
10720  UGT2B11; UDP-glucuronosyltransferase 2B11 precursor [KO:K00699] [EC:2.4.1.17]
10941  UGT2A1; UDP-glucuronosyltransferase 2A1 isoform 3 precursor [KO:K00699] [EC:2.4.1.17]
231  AKR1B1; aldo-keto reductase family 1 member B1 isoform 1 [KO:K00011] [EC:1.1.1.21]
27294  DHDH; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]
28970  C11orf54; ester hydrolase C11orf54 isoform a [KO:K28954]
2990  GUSB; beta-glucuronidase isoform 1 precursor [KO:K01195] [EC:3.2.1.31]
441282  AKR1B15; aldo-keto reductase family 1 member B15 isoform b [KO:K00011] [EC:1.1.1.21]
51084  CRYL1; lambda-crystallin homolog isoform 1 [KO:K13247] [EC:1.1.1.45]
51181  DCXR; L-xylulose reductase isoform 1 [KO:K03331] [EC:1.1.1.10]
54490  UGT2B28; UDP-glucuronosyltransferase 2B28 isoform 1 precursor [KO:K00699] [EC:2.4.1.17]
54575  UGT1A10; UDP-glucuronosyltransferase 1A10 precursor [KO:K00699] [EC:2.4.1.17]
54576  UGT1A8; UDP-glucuronosyltransferase 1A8 precursor [KO:K00699] [EC:2.4.1.17]
54577  UGT1A7; UDP-glucuronosyltransferase 1A7 precursor [KO:K00699] [EC:2.4.1.17]
54578  UGT1A6; UDP-glucuronosyltransferase 1A6 isoform 1 precursor [KO:K00699] [EC:2.4.1.17]
54579  UGT1A5; UDP-glucuronosyltransferase 1A5 precursor [KO:K00699] [EC:2.4.1.17]
54600  UGT1A9; UDP-glucuronosyltransferase 1A9 precursor [KO:K00699] [EC:2.4.1.17]
54657  UGT1A4; UDP-glucuronosyltransferase 1A4 precursor [KO:K00699] [EC:2.4.1.17]
54658  UGT1A1; UDP-glucuronosyltransferase 1A1 precursor [KO:K00699] [EC:2.4.1.17]
54659  UGT1A3; UDP-glucuronosyltransferase 1A3 precursor [KO:K00699] [EC:2.4.1.17]
55277  FGGY; FGGY carbohydrate kinase domain-containing protein isoform b [KO:K00875] [EC:2.7.1.47]
57016  AKR1B10; aldo-keto reductase family 1 member B10 [KO:K00011] [EC:1.1.1.21]
574537  UGT2A2; UDP-glucuronosyltransferase 2A2 isoform UGT2A2_i1 precursor [KO:K00699] [EC:2.4.1.17]
6120  RPE; ribulose-phosphate 3-epimerase isoform 1 [KO:K01783] [EC:5.1.3.1]
6652  SORD; sorbitol dehydrogenase [KO:K00008] [EC:1.1.1.14]
729020  RPEL1; ribulose-phosphate 3-epimerase-like protein 1 [KO:K01783] [EC:5.1.3.1]
729920  CRPPA; D-ribitol-5-phosphate cytidylyltransferase isoform a [KO:K21031] [EC:2.7.7.40]
7358  UGDH; UDP-glucose 6-dehydrogenase isoform 1 [KO:K00012] [EC:1.1.1.22]
7360  UGP2; UTP--glucose-1-phosphate uridylyltransferase isoform a [KO:K00963] [EC:2.7.7.9]
7363  UGT2B4; UDP-glucuronosyltransferase 2B4 isoform 1 precursor [KO:K00699] [EC:2.4.1.17]
7364  UGT2B7; UDP-glucuronosyltransferase 2B7 isoform 1 precursor [KO:K00699] [EC:2.4.1.17]
7365  UGT2B10; UDP-glucuronosyltransferase 2B10 isoform 1 precursor [KO:K00699] [EC:2.4.1.17]
7366  UGT2B15; UDP-glucuronosyltransferase 2B15 precursor [KO:K00699] [EC:2.4.1.17]
7367  UGT2B17; UDP-glucuronosyltransferase 2B17 precursor [KO:K00699] [EC:2.4.1.17]
79799  UGT2A3; UDP-glucuronosyltransferase 2A3 precursor [KO:K00699] [EC:2.4.1.17]
9365  KL; klotho precursor [KO:K14756] [EC:3.2.1.31]
9942  XYLB; xylulose kinase isoform 2 [KO:K00854] [EC:2.7.1.17]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00116  Glycerol
C00167  UDP-glucuronate
C00181  D-Xylose
C00191  D-Glucuronate
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00266  Glycolaldehyde
C00309  D-Ribulose
C00310  D-Xylulose
C00312  L-Xylulose
C00333  D-Galacturonate
C00379  Xylitol
C00433  2,5-Dioxopentanoate
C00470  Pectate
C00474  Ribitol
C00476  D-Lyxose
C00502  D-Xylonate
C00508  L-Ribulose
C00514  D-Mannonate
C00532  L-Arabitol
C00558  D-Tagaturonate
C00618  3-Dehydro-L-gulonate
C00714  Pectin
C00789  CDP-ribitol
C00800  L-Gulonate
C00817  D-Altronate
C00905  D-Fructuronate
C01068  D-Ribitol 5-phosphate
C01101  L-Ribulose 5-phosphate
C01508  L-Lyxose
C01904  D-Arabitol
C02266  D-Xylonolactone
C02273  Digalacturonate
C02426  L-Glyceraldehyde
C02753  D-Xylono-1,4-lactone
C03033  beta-D-Glucuronoside
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C04053  5-Dehydro-4-deoxy-D-glucuronate
C04349  (4S)-4,6-Dihydroxy-2,5-dioxohexanoate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C06118  4-(4-Deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate
C06441  L-Xylulose 1-phosphate
C14899  3-Dehydro-L-gulonate 6-phosphate
C15930  L-Galactonate
C20680  2-Dehydro-3-deoxy-L-galactonate
C20902  3,6-Anhydro-alpha-L-galactopyranose
C20903  3,6-Anhydro-L-galactonate
C22337  D-Ribulose 1-phosphate
C22712  4-Deoxy-L-threo-hex-4-enopyranuronate
Reference
  Authors
Yew WS, Gerlt JA.
  Title
Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons.
  Journal
J Bacteriol 184:302-6 (2002)
DOI:10.1128/JB.184.1.302-306.2002
Reference
  Authors
Yew WS, Akana J, Wise EL, Rayment I, Gerlt JA
  Title
Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase.
  Journal
Biochemistry 44:1807-15 (2005)
DOI:10.1021/bi047815v
Reference
  Authors
Yasueda H, Kawahara Y, Sugimoto S.
  Title
Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression.
  Journal
J Bacteriol 181:7154-60 (1999)
DOI:10.1128/JB.181.23.7154-7160.1999
Reference
  Authors
Ibanez E, Gimenez R, Pedraza T, Baldoma L, Aguilar J, Badia J
  Title
Role of the yiaR and yiaS genes of Escherichia coli in metabolism of endogenously formed L-xylulose.
  Journal
J Bacteriol 182:4625-7 (2000)
DOI:10.1128/JB.182.16.4625-4627.2000
Reference
  Authors
Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N
  Title
The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway.
  Journal
J Bacteriol 187:3636-42 (2005)
DOI:10.1128/JB.187.11.3636-3642.2005
Related
pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00020  Citrate cycle (TCA cycle)
hsa00030  Pentose phosphate pathway
hsa00052  Galactose metabolism
hsa00053  Ascorbate and aldarate metabolism
hsa00520  Amino sugar and nucleotide sugar metabolism
hsa00561  Glycerolipid metabolism
hsa00562  Inositol phosphate metabolism
hsa00740  Riboflavin metabolism
KO pathway
ko00040   

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