KEGG   PATHWAY: hsa00450
Entry
hsa00450                    Pathway                                
Name
Selenocompound metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of other amino acids
Pathway map
hsa00450  Selenocompound metabolism
hsa00450

Organism
Homo sapiens (human) [GN:hsa]
Gene
56267  KYAT3; kynurenine aminotransferase 3 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
883  KYAT1; kynurenine aminotransferase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
4548  MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase [KO:K00548] [EC:2.1.1.13]
1491  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
51540  SCLY; selenocysteine lyase [KO:K01763] [EC:4.4.1.16]
7296  TXNRD1; thioredoxin reductase 1 [KO:K22182] [EC:1.8.1.9]
114112  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
10587  TXNRD2; thioredoxin reductase 2 [KO:K22182] [EC:1.8.1.9]
11185  INMT; indolethylamine N-methyltransferase [KO:K00562] [EC:2.1.1.49 2.1.1.96]
9060  PAPSS2; 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
9061  PAPSS1; 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
22928  SEPHS2; selenophosphate synthetase 2 [KO:K01008] [EC:2.7.9.3]
22929  SEPHS1; selenophosphate synthetase 1 [KO:K01008] [EC:2.7.9.3]
118672  PSTK; phosphoseryl-tRNA kinase [KO:K10837] [EC:2.7.1.164]
51091  SEPSECS; Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [KO:K03341] [EC:2.9.1.2]
4141  MARS1; methionyl-tRNA synthetase 1 [KO:K01874] [EC:6.1.1.10]
92935  MARS2; methionyl-tRNA synthetase 2, mitochondrial [KO:K01874] [EC:6.1.1.10]
Compound
C00017  Protein
C00041  L-Alanine
C01528  Hydrogen selenide
C02535  Dimethyl selenide
C05172  Selenophosphoric acid
C05335  L-Selenomethionine
C05336  Selenomethionyl-tRNA(Met)
C05684  Selenite
C05686  Adenylylselenate
C05688  L-Selenocysteine
C05689  Se-Methyl-L-selenocysteine
C05690  Se-Methylselenomethionine
C05695  gamma-Glutamyl-Se-methylselenocysteine
C05697  Selenate
C05698  Selenohomocysteine
C05699  L-Selenocystathionine
C05703  Methaneselenol
C06481  L-Seryl-tRNA(Sec)
C06482  L-Selenocysteinyl-tRNA(Sec)
C16638  O-Phosphoseryl-tRNA(Sec)
C18870  Selenodiglutathione
C18871  Glutathioselenol
C18872  Trimethylselenonium
C18893  1-Methylseleno-N-acetyl-D-galactosamine
C18902  Methylselenic acid
C18904  Methylselenopyruvate
C18905  Methylselenocysteine Se-oxide
Reference
PMID:21190829
  Authors
Hoefig CS, Renko K, Kohrle J, Birringer M, Schomburg L
  Title
Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture.
  Journal
J Nutr Biochem 22:945-55 (2011)
DOI:10.1016/j.jnutbio.2010.08.006
Reference
PMID:19051051
  Authors
McKenzie MJ, Hunter DA, Pathirana R, Watson LM, Joyce NI, Matich AJ, Rowan DD, Brummell DA
  Title
Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators.
  Journal
Transgenic Res 18:407-24 (2009)
DOI:10.1007/s11248-008-9233-0
Reference
PMID:20383543
  Authors
Pinto JT, Lee JI, Sinha R, MacEwan ME, Cooper AJ
  Title
Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds.
  Journal
Amino Acids 41:29-41 (2011)
DOI:10.1007/s00726-010-0578-3
Reference
PMID:17451884
  Authors
Suzuki KT, Kurasaki K, Suzuki N
  Title
Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide.
  Journal
Biochim Biophys Acta 1770:1053-61 (2007)
DOI:10.1016/j.bbagen.2007.03.007
Reference
PMID:11782468
  Authors
Gromer S, Gross JH
  Title
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
  Journal
J Biol Chem 277:9701-6 (2002)
DOI:10.1074/jbc.M109234200
KO pathway
ko00450   
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