KEGG   PATHWAY: aof00260
Entry
aof00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Asparagus officinalis (garden asparagus)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
aof00260  Glycine, serine and threonine metabolism
aof00260

Module
aof_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:aof00260]
aof_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:aof00260]
aof_M00555  Betaine biosynthesis, choline => betaine [PATH:aof00260]
aof_M00621  Glycine cleavage system [PATH:aof00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Asparagus officinalis (garden asparagus) [GN:aof]
Gene
109823820  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
109824940  aspartokinase 1, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
109842972  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
109850085  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
109847724  uncharacterized protein LOC109847724 [KO:K00133] [EC:1.2.1.11]
109830672  uncharacterized protein LOC109830672 isoform X1 [KO:K00003] [EC:1.1.1.3]
109820819  LOW QUALITY PROTEIN: homoserine kinase [KO:K00872] [EC:2.7.1.39]
109830638  threonine synthase 1, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
109840993  LOW QUALITY PROTEIN: threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
109836358  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
109823616  LOW QUALITY PROTEIN: serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
109823664  LOW QUALITY PROTEIN: serine hydroxymethyltransferase 4-like [KO:K00600] [EC:2.1.2.1]
109826783  serine hydroxymethyltransferase 3, chloroplastic isoform X1 [KO:K00600] [EC:2.1.2.1]
109830315  serine hydroxymethyltransferase 7 isoform X1 [KO:K00600] [EC:2.1.2.1]
109831518  LOW QUALITY PROTEIN: serine hydroxymethyltransferase 4-like [KO:K00600] [EC:2.1.2.1]
109844339  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
109819602  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
109834444  LOW QUALITY PROTEIN: serine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
109837681  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
109838946  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
109832677  uncharacterized protein LOC109832677 isoform X1 [KO:K01834] [EC:5.4.2.11]
109828710  uncharacterized protein LOC109828710 [KO:K01834] [EC:5.4.2.11]
109833937  uncharacterized protein LOC109833937 [KO:K01834] [EC:5.4.2.11]
109832858  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
109831575  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
109849847  2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like isoform X1 [KO:K15633] [EC:5.4.2.12]
109819613  2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like [KO:K15633] [EC:5.4.2.12]
109822239  D-glycerate 3-kinase, chloroplastic [KO:K15918] [EC:2.7.1.31]
109842614  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
109841111  D-3-phosphoglycerate dehydrogenase 1, chloroplastic isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
109843911  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
109825558  phosphoserine phosphatase, chloroplastic-like [KO:K01079] [EC:3.1.3.3]
109834086  phosphoserine phosphatase, chloroplastic-like [KO:K01079] [EC:3.1.3.3]
109825605  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
109833761  LOW QUALITY PROTEIN: primary amine oxidase 1-like [KO:K00276] [EC:1.4.3.21]
109824828  uncharacterized protein LOC109824828 [KO:K00276] [EC:1.4.3.21]
109832772  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
109822299  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
109844894  LOW QUALITY PROTEIN: aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
109831458  LOW QUALITY PROTEIN: dihydrolipoyl dehydrogenase 1, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
109848592  dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
109822343  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
109845495  glycine cleavage system H protein 2, mitochondrial-like [KO:K02437]
109822323  glycine cleavage system H protein 3, mitochondrial-like [KO:K02437]
109833902  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
109850512  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
109819957  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
109833434  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
109842258  choline monooxygenase, chloroplastic [KO:K00499] [EC:1.14.15.7]
109835690  LOW QUALITY PROTEIN: betaine aldehyde dehydrogenase 1, chloroplastic-like [KO:K00130] [EC:1.2.1.8]
109826632  betaine aldehyde dehydrogenase 2, mitochondrial-like [KO:K00130] [EC:1.2.1.8]
109834900  LOW QUALITY PROTEIN: betaine aldehyde dehydrogenase 1, chloroplastic-like [KO:K00130] [EC:1.2.1.8]
109835692  LOW QUALITY PROTEIN: betaine aldehyde dehydrogenase 2, mitochondrial-like [KO:K00130] [EC:1.2.1.8]
109823263  betaine aldehyde dehydrogenase 2, mitochondrial-like [KO:K00130] [EC:1.2.1.8]
109845011  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
109840378  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
109840383  LOW QUALITY PROTEIN: probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
109833826  LOW QUALITY PROTEIN: threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
109834972  threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
109847893  threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
109836957  LOW QUALITY PROTEIN: serine racemase [KO:K12235] [EC:5.1.1.18]
109833036  tryptophan synthase alpha chain-like isoform X1 [KO:K01695] [EC:4.2.1.20]
109834497  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
109834500  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
109835212  tryptophan synthase alpha chain-like isoform X1 [KO:K01695] [EC:4.2.1.20]
109833341  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
109847979  LOW QUALITY PROTEIN: tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
109848233  tryptophan synthase beta chain 2, chloroplastic [KO:K01696] [EC:4.2.1.20]
109841028  uncharacterized protein LOC109841028 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
aof00010  Glycolysis / Gluconeogenesis
aof00020  Citrate cycle (TCA cycle)
aof00230  Purine metabolism
aof00250  Alanine, aspartate and glutamate metabolism
aof00270  Cysteine and methionine metabolism
aof00290  Valine, leucine and isoleucine biosynthesis
aof00300  Lysine biosynthesis
aof00330  Arginine and proline metabolism
aof00460  Cyanoamino acid metabolism
aof00470  D-Amino acid metabolism
aof00564  Glycerophospholipid metabolism
aof00600  Sphingolipid metabolism
aof00620  Pyruvate metabolism
aof00630  Glyoxylate and dicarboxylate metabolism
aof00640  Propanoate metabolism
aof00860  Porphyrin metabolism
aof00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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