KEGG   PATHWAY: clus00564
Entry
clus00564                   Pathway                                
Name
Glycerophospholipid metabolism - Clavispora lusitaniae CBS 6936
Class
Metabolism; Lipid metabolism
Pathway map
clus00564  Glycerophospholipid metabolism
clus00564

Module
clus_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:clus00564]
clus_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:clus00564]
clus_M00093  Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:clus00564]
Other DBs
GO: 0006650
Organism
Clavispora lusitaniae CBS 6936 [GN:clus]
Gene
A9F13_01g08459  putative glycerol-3-phosphate dehydrogenase [NAD(+)] [KO:K00006] [EC:1.1.1.8]
A9F13_03g00913  putative glycerol-3-phosphate dehydrogenase [NAD(+)] [KO:K00006] [EC:1.1.1.8]
A9F13_01g03894  putative glycerol-3-phosphate dehydrogenase [KO:K00111] [EC:1.1.5.3]
A9F13_06g01573  putative bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase [KO:K13507] [EC:2.3.1.15 2.3.1.42]
A9F13_16g00418  putative bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase [KO:K13507] [EC:2.3.1.15 2.3.1.42]
A9F13_11g01089  putative 1-acyl-sn-glycerol-3-phosphate acyltransferase [KO:K13509] [EC:2.3.1.51]
A9F13_11g01716  putative lysophospholipid acyltransferase [KO:K13519] [EC:2.3.1.51 2.3.1.23 2.3.1.-]
A9F13_15g00385  putative lipase 4 [KO:K14674] [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51]
A9F13_28g00121  putative lysophosphatidic acid acyltransferase [KO:K22831] [EC:2.3.1.51]
A9F13_04g03014  putative acylglycerone-phosphate reductase [KO:K06123] [EC:1.1.1.101]
A9F13_02g02398  putative NADPH-dependent 1-acyldihydroxyacetone phosphate reductase [KO:K06123] [EC:1.1.1.101]
A9F13_13g01980  putative phosphatidate phosphatase [KO:K15728] [EC:3.1.3.4]
A9F13_05g02387  putative bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase [KO:K18693] [EC:3.6.1.75 3.1.3.4]
A9F13_02g01320  putative phosphatidate phosphatase [KO:K18693] [EC:3.6.1.75 3.1.3.4]
A9F13_03g03168  putative diacylglycerol pyrophosphate phosphatase [KO:K18693] [EC:3.6.1.75 3.1.3.4]
A9F13_04g01188  putative diacylglycerol kinase [KO:K16368] [EC:2.7.1.174]
A9F13_01g03366  putative phosphatidylglycerol phospholipase [KO:K18694] [EC:3.1.4.-]
A9F13_05g00396  putative phospholipase D [KO:K01115] [EC:3.1.4.4]
A9F13_20g00968  putative lysophospholipase [KO:K13333] [EC:3.1.1.5]
A9F13_06g03465  putative lysophospholipase [KO:K13333] [EC:3.1.1.5]
A9F13_02g00880  putative lysophospholipase [KO:K13333] [EC:3.1.1.5]
A9F13_06g03289  putative lysophospholipase [KO:K14676] [EC:3.1.1.5]
A9F13_07g00759  putative glycerophosphocholine phosphodiesterase [KO:K18696] [EC:3.1.4.46]
A9F13_14g00176  putative bifunctional choline kinase/ethanolamine kinase [KO:K00866] [EC:2.7.1.32]
A9F13_21g00891  putative choline-phosphate cytidylyltransferase [KO:K00968] [EC:2.7.7.15]
A9F13_01g05214  putative bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase [KO:K00993] [EC:2.7.8.1]
A9F13_05g02376  putative ethanolamine kinase [KO:K00894] [EC:2.7.1.82]
A9F13_06g01320  putative ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
A9F13_04g03245  putative bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
A9F13_02g00616  putative phosphatidylethanolamine N-methyltransferase [KO:K16369] [EC:2.1.1.17]
A9F13_07g02508  putative phosphatidate cytidylyltransferase [KO:K00981] [EC:2.7.7.41]
A9F13_07g01287  putative CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
A9F13_21g00759  putative phosphatidylserine decarboxylase proenzyme [KO:K01613] [EC:4.1.1.65]
A9F13_04g00264  putative phosphatidylserine decarboxylase proenzyme [KO:K01613] [EC:4.1.1.65]
A9F13_14g01375  putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [KO:K00995] [EC:2.7.8.5]
A9F13_05g02299  putative phosphatidylglycerophosphatase [KO:K01094] [EC:3.1.3.27]
A9F13_01g07293  putative cardiolipin synthase [KO:K08744] [EC:2.7.8.41]
A9F13_13g00781  putative lysophosphatidylcholine acyltransferase [KO:K13511] [EC:2.3.1.-]
A9F13_14g00726  putative cardiolipin-specific deacylase [KO:K13535] [EC:3.1.1.-]
A9F13_13g00066  putative carboxylic ester hydrolase [KO:K13535] [EC:3.1.1.-]
A9F13_04g00814  putative cardiolipin-specific deacylase [KO:K13535] [EC:3.1.1.-]
A9F13_02g01936  putative CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
A9F13_18g00154  putative S-adenosyl-L-methionine-dependent methyltransferase [KO:K13621]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
clus00010  Glycolysis / Gluconeogenesis
clus00260  Glycine, serine and threonine metabolism
clus00561  Glycerolipid metabolism
clus00562  Inositol phosphate metabolism
clus00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
clus00565  Ether lipid metabolism
clus00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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