KEGG   PATHWAY: dpol00983
Entry
dpol00983                   Pathway                                
Name
Drug metabolism - other enzymes - Dreissena polymorpha (zebra mussel)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
dpol00983  Drug metabolism - other enzymes
dpol00983

Organism
Dreissena polymorpha (zebra mussel) [GN:dpol]
Gene
127855547  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
127881774  inosine-5'-monophosphate dehydrogenase 1-like isoform X1 [KO:K00088] [EC:1.1.1.205]
127881833  GMP synthase [glutamine-hydrolyzing]-like isoform X1 [KO:K01951] [EC:6.3.5.2]
127864084  thiopurine S-methyltransferase-like isoform X1 [KO:K00569] [EC:2.1.1.67]
127850133  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
127850202  thiopurine S-methyltransferase-like isoform X1 [KO:K00569] [EC:2.1.1.67]
127874304  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
127874321  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
127855585  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
127865162  uncharacterized protein LOC127865162 isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127852722  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127852926  uncharacterized protein LOC127852926 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127871794  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127877386  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127874495  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
127874496  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
127874497  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
127844542  carboxylesterase 5A-like isoform X1 [KO:K01044] [EC:3.1.1.1]
127882442  liver carboxylesterase 1F-like [KO:K01044] [EC:3.1.1.1]
127870234  acetylcholinesterase-like [KO:K01044] [EC:3.1.1.1]
127859970  neuroligin-4, X-linked-like [KO:K01044] [EC:3.1.1.1]
127833553  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
127882300  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
127842397  cytidine deaminase-like isoform X1 [KO:K01489] [EC:3.5.4.5]
127850874  thymidine phosphorylase-like isoform X1 [KO:K00758] [EC:2.4.2.4]
127855252  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
127832087  dihydropyrimidinase-like isoform X1 [KO:K01464] [EC:3.5.2.2]
127872632  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
127859416  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
127860936  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
127839078  uridine-cytidine kinase 2-like [KO:K00876] [EC:2.7.1.48]
127842898  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
127882073  thymidine kinase 2, mitochondrial-like isoform X1 [KO:K00857] [EC:2.7.1.21]
127866750  thymidine kinase, cytosolic-like isoform X1 [KO:K00857] [EC:2.7.1.21]
127846510  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
127868910  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
127882284  uridine 5'-monophosphate synthase-like isoform X1 [KO:K13421] [EC:2.4.2.10 4.1.1.23]
127860834  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
127879234  ribonucleoside-diphosphate reductase large subunit-like isoform X1 [KO:K10807] [EC:1.17.4.1]
127861616  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
127872330  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
127833368  nucleoside diphosphate kinase 7-like isoform X1 [KO:K00940] [EC:2.7.4.6]
127876784  uncharacterized protein LOC127876784 [KO:K00940] [EC:2.7.4.6]
127876898  uncharacterized protein LOC127876898 [KO:K00940] [EC:2.7.4.6]
127867004  deoxyuridine 5'-triphosphate nucleotidohydrolase-like isoform X1 [KO:K01520] [EC:3.6.1.23]
127859015  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
127859016  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
127863206  chorion peroxidase-like [KO:K10789] [EC:1.11.2.2]
127866032  peroxidasin homolog pxn-2-like [KO:K10789] [EC:1.11.2.2]
127845366  myeloperoxidase-like isoform X1 [KO:K10789] [EC:1.11.2.2]
127845367  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
127847020  myeloperoxidase-like isoform X1 [KO:K10789] [EC:1.11.2.2]
127848042  lactoperoxidase-like [KO:K10789] [EC:1.11.2.2]
127849115  peroxidase-like protein 3 [KO:K10789] [EC:1.11.2.2]
127849117  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
127849118  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
127873828  peroxidasin homolog pxn-2-like [KO:K10789] [EC:1.11.2.2]
127860390  myeloperoxidase-like isoform X1 [KO:K10789] [EC:1.11.2.2]
127878283  chorion peroxidase-like [KO:K10789] [EC:1.11.2.2]
127879920  chorion peroxidase-like [KO:K10789] [EC:1.11.2.2]
127844130  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
127844144  probable glutathione S-transferase 7 [KO:K00799] [EC:2.5.1.18]
127845100  pyrimidodiazepine synthase-like [KO:K00799] [EC:2.5.1.18]
127865039  S-crystallin SL11-like [KO:K00799] [EC:2.5.1.18]
127865042  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127865043  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
127882287  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
127882438  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127882447  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127882449  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
127845277  probable glutathione S-transferase 7 [KO:K00799] [EC:2.5.1.18]
127846583  glutathione S-transferase theta-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127867177  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
127867940  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
127868904  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
127868983  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
127850715  microsomal glutathione S-transferase 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127871422  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
127831548  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
127871640  glutathione S-transferase theta-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127874805  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
127837130  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
127837149  uncharacterized protein LOC127837149 [KO:K00799] [EC:2.5.1.18]
127876588  microsomal glutathione S-transferase 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127876589  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
127839253  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
127859852  probable glutathione S-transferase 7 [KO:K00799] [EC:2.5.1.18]
127860789  probable glutathione S-transferase 7 isoform X1 [KO:K00799] [EC:2.5.1.18]
127879357  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
127879507  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
127852352  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
127852353  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
127852354  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
127853433  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
127854132  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system