KEGG   PATHWAY: dso01210
Entry
dso01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Dickeya solani IPO 2222
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
dso01210  2-Oxocarboxylic acid metabolism
dso01210

Module
dso_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:dso01210]
dso_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:dso01210]
dso_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:dso01210]
dso_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:dso01210]
dso_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:dso01210]
dso_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:dso01210]
Organism
Dickeya solani IPO 2222 [GN:dso]
Related
pathway
dso00020  Citrate cycle (TCA cycle)
dso00220  Arginine biosynthesis
dso00250  Alanine, aspartate and glutamate metabolism
dso00260  Glycine, serine and threonine metabolism
dso00270  Cysteine and methionine metabolism
dso00290  Valine, leucine and isoleucine biosynthesis
dso00300  Lysine biosynthesis
dso00310  Lysine degradation
dso00620  Pyruvate metabolism
dso00640  Propanoate metabolism
dso00680  Methane metabolism
KO pathway
ko01210   
LinkDB

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