KEGG   PATHWAY: ec00404
Entry
ec00404                     Pathway                                
Name
Staurosporine biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
ec00404  Staurosporine biosynthesis
ec00404

Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A [PATH:ec00404]
M00789  Rebeccamycin biosynthesis, tryptophan => rebeccamycin [PATH:ec00404]
M00790  Pyrrolnitrin biosynthesis, tryptophan => pyrrolnitrin [PATH:ec00404]
M00805  Staurosporine biosynthesis, tryptophan => staurosporine [PATH:ec00404]
M00808  Violacein biosynthesis, tryptophan => violacein [PATH:ec00404]
Enzyme
1.13.12.17   
1.14.11.38   
1.14.13.217   
1.14.13.224   
1.14.14.118   
1.14.14.119   
1.14.19.71   
1.14.19.9   
1.21.98.2   
1.4.3.23   
2.1.1.139   
2.1.1.164   
2.1.1.293   
2.5.1.106   
2.5.1.107   
2.5.1.110   
4.3.3.5   
Compound
C00078  L-Tryptophan
C00135  L-Histidine
C00148  L-Proline
C02079  Staurosporine
C07349  3'-Demethylstaurosporine
C12318  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose
C12491  Pyrrolnitrin
C18092  dTDP-L-ristosamine
C19687  7-Chloro-L-tryptophan
C19688  2-Imino-3-(7-chloroindol-3-yl)propanoate
C19698  3,4-Bis(7-chloroindol-3-yl)pyrrole-2,5-dicarboxylate
C19699  Dichloroarcyriaflavin A
C19700  4'-O-Demethylrebeccamycin
C19701  Rebeccamycin
C20045  Verruculogen
C20512  Tryprostatin B
C20513  6-Hydroxytryprostatin B
C20563  Brevianamide F
C20564  Fumitremorgin A
C20604  Fumitremorgin C
C20605  12alpha,13alpha-Dihydroxyfumitremorgin C
C20607  Tryprostatin A
C20630  Fumitremorgin B
C21109  Aminopyrrolnitrin
C21110  Monodechloroaminopyrrolnitrin
C21124  IPA imine
C21125  Chromopyrrolate
C21126  K-252c
C21127  Holyrine A
C21128  O-Demethyl-N-demethyl-staurosporine
C21131  Protodeoxyviolaceinic acid
C21132  Deoxyviolaceinic acid
C21133  Deoxyviolacein
C21134  Protoviolaceinic acid
C21135  Violaceinic acid
C21136  Violacein
C21137  dTDP-3-amino-4-oxo-2,3,6-trideoxy-L-allose
C22162  Histidyltryptophyldiketopiperazine
C22163  Roquefortine D
C22164  Dehydrohistidyltryptophyldiketopiperazine
C22165  Roquefortine C
C22166  Glandicoline A
C22167  Glandicoline B
C22168  Meleagrin
C22169  N1-Hydroxy-roquefortine C
C22170  Roquefortine L
C22171  Roquefortine F
C22172  Neoxaline
Reference
PMID:17119643
  Authors
Sanchez C, Mendez C, Salas JA
  Title
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity.
  Journal
Nat Prod Rep 23:1007-45 (2006)
DOI:10.1039/b601930g
Reference
PMID:12617516
  Authors
Onaka H, Taniguchi S, Igarashi Y, Furumai T
  Title
Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.
  Journal
J Antibiot (Tokyo) 55:1063-71 (2002)
DOI:10.7164/antibiotics.55.1063
Reference
PMID:24038353
  Authors
Lee ME, Aswani A, Han AS, Tomlin CJ, Dueber JE
  Title
Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay.
  Journal
Nucleic Acids Res 41:10668-78 (2013)
DOI:10.1093/nar/gkt809
Reference
PMID:12619684
  Authors
Onaka H, Taniguchi S, Igarashi Y, Furumai T
  Title
Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243.
  Journal
Biosci Biotechnol Biochem 67:127-38 (2003)
DOI:10.1271/bbb.67.127
Reference
PMID:9172332
  Authors
Hammer PE, Hill DS, Lam ST, Van Pee KH, Ligon JM
  Title
Four genes from Pseudomonas fluorescens that encode the biosynthesis of pyrrolnitrin.
  Journal
Appl Environ Microbiol 63:2147-54 (1997)
DOI:10.1128/AEM.63.6.2147-2154.1997
Reference
PMID:23109474
  Authors
Mundt K, Wollinsky B, Ruan HL, Zhu T, Li SM
  Title
Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches.
  Journal
Chembiochem 13:2583-92 (2012)
DOI:10.1002/cbic.201200523
Related
pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec00523  Polyketide sugar unit biosynthesis
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