KEGG   PATHWAY: eco00360
Entry
eco00360                    Pathway                                
Name
Phenylalanine metabolism - Escherichia coli K-12 MG1655
Class
Metabolism; Amino acid metabolism
Pathway map
eco00360  Phenylalanine metabolism
eco00360

Module
eco_M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA [PATH:eco00360]
eco_M00878  Phenylacetate degradation, phenylaxetate => acetyl-CoA/succinyl-CoA [PATH:eco00360]
Other DBs
GO: 0006558
Organism
Escherichia coli K-12 MG1655 [GN:eco]
Gene
b1386  tynA; copper-containing amine oxidase [KO:K00276] [EC:1.4.3.21]
b1385  feaB; phenylacetaldehyde dehydrogenase [KO:K00146] [EC:1.2.1.39]
b1398  paaK; phenylacetate-CoA ligase [KO:K01912] [EC:6.2.1.30]
b1396  paaI; phenylacetyl-CoA thioesterase [KO:K02614] [EC:3.1.2.-]
b1388  paaA; phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit [KO:K02609] [EC:1.14.13.149]
b1389  paaB; phenylacetyl-CoA 1,2-epoxidase subunit B [KO:K02610]
b1390  paaC; phenylacetyl-CoA 1,2-epoxidase, structural subunit [KO:K02611] [EC:1.14.13.149]
b1391  paaD; phenylacetate degradation protein [KO:K02612]
b1392  paaE; phenylacetyl-CoA 1,2-epoxidase, reductase subunit [KO:K02613]
b1394  paaG; putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) [KO:K15866] [EC:5.3.3.18]
b1387  paaZ; fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase [KO:K02618] [EC:3.3.2.12 1.2.1.91]
b1397  paaJ; beta-ketoadipyl-CoA thiolase [KO:K02615] [EC:2.3.1.223 2.3.1.174]
b1393  paaF; putative 2,3-dehydroadipyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
b1395  paaH; 3-hydroxyadipyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
b0928  aspC; aspartate aminotransferase [KO:K00813] [EC:2.6.1.1]
b2021  hisC; histidinol-phosphate aminotransferase [KO:K00817] [EC:2.6.1.9]
b4054  tyrB; tyrosine aminotransferase [KO:K00832] [EC:2.6.1.57]
b3441  yhhY; N-acetyltransferase YhhY [KO:K03825] [EC:2.3.1.53 2.3.1.-]
b1189  dadA; D-amino acid dehydrogenase [KO:K00285] [EC:1.4.5.1]
b0801  hcxB; hydroxycarboxylate dehydrogenase B [KO:K13574] [EC:1.1.1.237 1.1.1.-]
b3942  katG; catalase/hydroperoxidase HPI [KO:K03782] [EC:1.11.1.21]
b2538  hcaE; putative 3-phenylpropionate/cinnamate dioxygenase subunit alpha [KO:K05708] [EC:1.14.12.19]
b2539  hcaF; putative 3-phenylpropionate/cinnamate dioxygenase subunit beta [KO:K05709] [EC:1.14.12.19]
b2540  hcaC; putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin subunit [KO:K05710]
b2542  hcaD; putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit [KO:K00529] [EC:1.18.1.3]
b2541  hcaB; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase [KO:K05711] [EC:1.3.1.87]
b0347  mhpA; 3-(3-hydroxyphenyl)propanoate hydroxylase [KO:K05712] [EC:1.14.13.127]
b0348  mhpB; 3-carboxyethylcatechol 2,3-dioxygenase [KO:K05713] [EC:1.13.11.16]
b0349  mhpC; 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase [KO:K05714] [EC:3.7.1.14]
b0350  mhpD; 2-hydroxypentadienoate hydratase [KO:K02554] [EC:4.2.1.80]
b0352  mhpE; 4-hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
b0351  mhpF; acetaldehyde dehydrogenase (acetylating) MhpF [KO:K04073] [EC:1.2.1.10]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00042  Succinate
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00084  Acetaldehyde
C00091  Succinyl-CoA
C00122  Fumarate
C00166  Phenylpyruvate
C00423  trans-Cinnamate
C00512  Benzoyl-CoA
C00582  Phenylacetyl-CoA
C00596  2-Hydroxy-2,4-pentadienoate
C00601  Phenylacetaldehyde
C00642  4-Hydroxyphenylacetate
C01198  3-(2-Hydroxyphenyl)propanoate
C01772  trans-2-Hydroxycinnamate
C02137  alpha-Oxo-benzeneacetic acid
C02232  3-Oxoadipyl-CoA
C02265  D-Phenylalanine
C02505  2-Phenylacetamide
C02763  2-Hydroxy-3-phenylpropenoate
C03519  N-Acetyl-L-phenylalanine
C03589  4-Hydroxy-2-oxopentanoate
C04044  3-(2,3-Dihydroxyphenyl)propanoate
C04148  Phenylacetylglutamine
C04479  2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
C05332  Phenethylamine
C05593  3-Hydroxyphenylacetate
C05598  Phenylacetylglycine
C05607  Phenyllactate
C05629  Phenylpropanoate
C05852  2-Hydroxyphenylacetate
C05853  Phenylethyl alcohol
C06207  2,6-Dihydroxyphenylacetate
C07086  Phenylacetic acid
C11457  3-(3-Hydroxyphenyl)propanoic acid
C11588  cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
C12621  trans-3-Hydroxycinnamate
C12622  cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
C12623  trans-2,3-Dihydroxycinnamate
C12624  2-Hydroxy-6-ketononatrienedioate
C14144  5-Carboxy-2-pentenoyl-CoA
C14145  (3S)-3-Hydroxyadipyl-CoA
C15524  Phenylglyoxylyl-CoA
C19945  3-Oxo-5,6-dehydrosuberyl-CoA
C19946  3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde
C19975  2-Oxepin-2(3H)-ylideneacetyl-CoA
C20062  2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:10537203
  Authors
Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T.
  Title
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441.
  Journal
Microbiology 145 ( Pt 10):2813-20 (1999)
DOI:10.1099/00221287-145-10-2813
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
DOI:10.1128/JB.180.11.2915-2923.1998
Reference
PMID:9098055
  Authors
Ferrandez A, Garcia JL, Diaz E.
  Title
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
  Journal
J Bacteriol 179:2573-81 (1997)
DOI:10.1128/JB.179.8.2573-2581.1997
Reference
PMID:19016485
  Authors
Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG
  Title
Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.
  Journal
Biotechnol Bioeng 102:1323-9 (2009)
DOI:10.1002/bit.22178
Reference
PMID:20660314
  Authors
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G
  Title
Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
  Journal
Proc Natl Acad Sci U S A 107:14390-5 (2010)
DOI:10.1073/pnas.1005399107
Related
pathway
eco00010  Glycolysis / Gluconeogenesis
eco00020  Citrate cycle (TCA cycle)
eco00350  Tyrosine metabolism
eco00362  Benzoate degradation
eco00400  Phenylalanine, tyrosine and tryptophan biosynthesis
KO pathway
ko00360   
LinkDB

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