KEGG   PATHWAY: kpd01210
Entry
kpd01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Kangiella profundi
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
kpd01210  2-Oxocarboxylic acid metabolism
kpd01210

Module
kpd_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:kpd01210]
kpd_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:kpd01210]
kpd_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:kpd01210]
kpd_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:kpd01210]
Organism
Kangiella profundi [GN:kpd]
Related
pathway
kpd00020  Citrate cycle (TCA cycle)
kpd00220  Arginine biosynthesis
kpd00250  Alanine, aspartate and glutamate metabolism
kpd00260  Glycine, serine and threonine metabolism
kpd00270  Cysteine and methionine metabolism
kpd00290  Valine, leucine and isoleucine biosynthesis
kpd00300  Lysine biosynthesis
kpd00310  Lysine degradation
kpd00620  Pyruvate metabolism
kpd00640  Propanoate metabolism
kpd00680  Methane metabolism
KO pathway
ko01210   
LinkDB

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