Entry Name C-type lectin receptor signaling pathway
Description C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map map04625 C-type lectin receptor signaling pathway
Ortholog table Reference Authors Geijtenbeek TB, Gringhuis SI
Title C-type lectin receptors in the control of T helper cell differentiation.
Journal Reference Authors Hajishengallis G, Lambris JD
Title Microbial manipulation of receptor crosstalk in innate immunity.
Journal Reference Authors Iliev ID, Leonardi I
Title Fungal dysbiosis: immunity and interactions at mucosal barriers.
Journal Reference Authors Richardson MB, Williams SJ
Title MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
Journal Reference Authors Vautier S, MacCallum DM, Brown GD
Title C-type lectin receptors and cytokines in fungal immunity.
Journal Reference Authors Gauglitz GG, Callenberg H, Weindl G, Korting HC
Title Host defence against Candida albicans and the role of pattern-recognition receptors.
Journal Reference Authors Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
Title DAMP signaling in fungal infections and diseases.
Journal Reference Authors Tang J, Lin G, Langdon WY, Tao L, Zhang J
Title Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
Journal Reference Authors Mayer S, Raulf MK, Lepenies B
Title C-type lectins: their network and roles in pathogen recognition and immunity.
Journal Reference Authors Plato A, Willment JA, Brown GD
Title C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
Journal Reference Authors Dupaul-Chicoine J, Saleh M
Title A new path to IL-1beta production controlled by caspase-8.
Journal Reference Authors Batbayar S, Lee DH, Kim HW
Title Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
Journal Reference Authors Bendickova K, Tidu F, Fric J
Title Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
Journal Reference Authors den Dunnen J, Gringhuis SI, Geijtenbeek TB
Title Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
Journal Reference Authors Marakalala MJ, Ndlovu H
Title Signaling C-type lectin receptors in antimycobacterial immunity.
Journal Reference Authors Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
Title Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
Journal Reference Authors Geijtenbeek TB, Gringhuis SI
Title Signalling through C-type lectin receptors: shaping immune responses.
Journal Reference Authors Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
Title Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
Journal Related map00571 Lipoarabinomannan (LAM) biosynthesis
map04658 Th1 and Th2 cell differentiation
KO pathway LinkDB All DBs
