KEGG   PATHWAY: mna04666
Entry
mna04666                    Pathway                                
Name
Fc gamma R-mediated phagocytosis - Miniopterus natalensis (Natal long-fingered bat)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
Pathway map
mna04666  Fc gamma R-mediated phagocytosis
mna04666

Other DBs
GO: 0006909
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107545392  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
107535118  low affinity immunoglobulin gamma Fc region receptor III-like [KO:K06472]
107535119  low affinity immunoglobulin gamma Fc region receptor III-B-like [KO:K06463]
107540236  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
107527783  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
107533160  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
107529171  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
107532628  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107538463  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107541106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107526728  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107529317  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107535325  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107542383  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107528331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107534199  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107530082  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
107537414  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
107542131  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
107524904  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
107534935  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
107530341  protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
107534729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107533801  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107541504  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
107530451  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107546298  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
107536544  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
107536549  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
107536550  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
107536561  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
107544563  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
107542433  MARCKSL1; MARCKS-related protein [KO:K13536]
107528068  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
107529520  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
107533526  phospholipase D1 [KO:K01115] [EC:3.1.4.4]
107538563  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
107527147  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
107530656  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
107536591  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
107531908  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
107538300  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107544745  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
107540426  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
107546691  NCF1; neutrophil cytosol factor 1 [KO:K08011]
107541636  SCIN; adseverin [KO:K05768]
107537672  GSN; gelsolin isoform X1 [KO:K05768]
107525716  VAV1; proto-oncogene vav [KO:K05730]
107524668  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
107541170  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
107537179  guanine nucleotide exchange factor VAV3 [KO:K05730]
107538414  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107540891  cell division control protein 42 homolog [KO:K04393]
107541349  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
107536769  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
107545978  ACTR2; actin-related protein 2 [KO:K17260]
107524922  ACTR3B; actin-related protein 3B [KO:K18584]
107526917  ACTR3; actin-related protein 3 [KO:K18584]
107540948  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
107540907  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
107524752  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
107529597  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
107534754  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
107535481  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
107546303  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
107537599  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
107545262  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
107540702  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
107540073  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
107546408  WASF3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
107524443  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
107526542  LIMK1; LOW QUALITY PROTEIN: LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
107526171  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
107542803  CFL2; cofilin-2 [KO:K05765]
107533619  CFL1; cofilin-1 [KO:K05765]
107539122  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
107538124  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
107525631  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
107525849  ARF6; ADP-ribosylation factor 6 [KO:K07941]
107535608  CRK; adapter molecule crk isoform X1 [KO:K04438]
107530545  CRKL; crk-like protein [KO:K04438]
107535162  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
107538429  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
107526661  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
107539487  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488]
107535132  low affinity immunoglobulin gamma Fc region receptor II-b-like [KO:K12560]
107530717  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
107533662  INPPL1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
107524432  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
107541020  LAT; LOW QUALITY PROTEIN: linker for activation of T-cells family member 1 [KO:K07362]
107533288  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
107528583  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
107526626  AMPH; amphiphysin isoform X1 [KO:K12562]
107540533  MYO10; unconventional myosin-X [KO:K12559]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:12488490
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
DOI:10.1189/jlb.72.6.1092
Reference
PMID:11708889
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
DOI:10.1006/smim.2001.0330
Reference
PMID:15466916
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
DOI:10.1189/jlb.0804439
Reference
PMID:11244038
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
DOI:10.1146/annurev.immunol.19.1.275
Reference
PMID:18322649
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
DOI:10.1007/s00018-008-7578-4
Reference
PMID:10376013
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
DOI:10.1002/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#
Reference
PMID:10577498
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
DOI:10.1002/jlb.66.5.712
Reference
PMID:10224668
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
DOI:10.1016/S1357-2725(98)00108-3
Reference
PMID:11228151
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
PMID:17050193
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
DOI:10.1532/IJH97.06140
Reference
PMID:17308335
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200
Reference
PMID:11304556
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
DOI:10.1084/jem.193.8.955
Reference
PMID:15485887
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
DOI:10.1074/jbc.M408188200
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
DOI:10.1074/jbc.273.16.9393
Reference
PMID:12821647
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
DOI:10.1083/jcb.200212158
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
DOI:10.1074/jbc.273.1.441
Reference
PMID:10601359
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
DOI:10.1084/jem.190.12.1849
Reference
PMID:10755615
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
DOI:10.1016/S1074-7613(00)80181-8
Reference
PMID:10586078
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
DOI:10.1002/jlb.63.5.521
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)
Related
pathway
mna04020  Calcium signaling pathway
mna04142  Lysosome
mna04144  Endocytosis
mna04810  Regulation of actin cytoskeleton
KO pathway
ko04666   
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