Entry |
|
Name |
Clavulanic acid biosynthesis |
Class |
Metabolism; Biosynthesis of other secondary metabolites
|
Pathway map |
rn00331 | Clavulanic acid biosynthesis |
|
Module |
M00674 | Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate [PATH:rn00331] |
|
Reaction |
R05357 | amidinoproclavaminate amidinohydrolase |
R05466 | deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) |
R05467 | L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) |
R05468 | proclavaminate,2-oxoglutarate:oxygen oxidoreductase (cyclyzing) |
R05469 | dihydroclavaminate,2-oxoglutarate:oxygen oxidoreductase (desaturating) |
R05471 | clavulanate:NADP+ oxidoreductase |
|
Compound |
C00118 | D-Glyceraldehyde 3-phosphate |
C06655 | L-N2-(2-Carboxyethyl)arginine |
C06656 | Deoxyguanidinoproclavaminic acid |
C06657 | Guanidinoproclavaminic acid |
|
Reference |
|
Authors |
McGowan SJ, Bycroft BW, Salmond GP. |
Title |
Bacterial production of carbapenems and clavams: evolution of beta-lactam antibiotic pathways. |
Journal |
|
Reference |
|
Authors |
Caines ME, Elkins JM, Hewitson KS, Schofield CJ. |
Title |
Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway. |
Journal |
|
Related pathway |
|
KO pathway |
|
LinkDB |
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