| | PATHWAY: rn00360 | |
Entry |
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Name |
Phenylalanine metabolism |
Class |
Metabolism; Amino acid metabolism
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Pathway map |
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Module |
M00545 | Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA [PATH:rn00360] |
M00878 | Phenylacetate degradation, phenylaxetate => acetyl-CoA/succinyl-CoA [PATH:rn00360] |
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Other DBs |
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Reaction |
R00228 | acetaldehyde:NAD+ oxidoreductase (CoA-acetylating) |
R00686 | L-phenylalanine racemase (ATP-hydrolysing) |
R00688 | L-phenylalanine:NAD+ oxidoreductase (deaminating) |
R00689 | L-phenylalanine:oxygen oxidoreductase (deaminating) |
R00690 | L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating) |
R00692 | L-phenylalanine:pyruvate aminotransferase |
R00693 | acetyl-CoA:L-phenylalanine N-acetyltransferase |
R00694 | L-phenylalanine:2-oxoglutarate aminotransferase |
R00697 | L-phenylalanine ammonia-lyase (trans-cinnamate-forming) |
R00698 | L-phenylalanine:oxygen oxidoreductase (decarboxylating) |
R00699 | L-phenylalanine carboxy-lyase (phenylethylamine-forming) |
R00750 | 4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) |
R00829 | succinyl-CoA:acetyl-CoA C-acyltransferase |
R01370 | phenyllactate:NAD+ oxidoreductase |
R01371 | phenyllactate:NADP+ oxidoreductase |
R01372 | phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating) |
R01374 | D-phenylalanine:quinone oxidoreductase (deaminating) |
R01377 | phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming) |
R01378 | phenylpyruvate keto-enol-isomerase |
R01582 | D-phenylalanine:2-oxoglutarate aminotransferase |
R01795 | L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) |
R02252 | phenylpropanoate:NAD+ delta2-oxidoreductase |
R02254 | trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating) |
R02450 | phenylglyoxylate:NAD+ oxidoreductase (CoA benzoylating) |
R02536 | phenylacetaldehyde:NAD+ oxidoreductase |
R02537 | aldehyde:NADP+ oxidoreductase |
R02539 | phenylacetate:CoA ligase |
R02540 | 2-phenylacetamide amidohydrolase |
R02576 | phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase |
R02601 | 4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming) |
R02603 | 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate succinylhydrolase |
R02611 | phenylethylalcohol:NAD+ oxidoreductase |
R02612 | phenethylamine:(acceptor) oxidoreductase (deaminating) |
R02613 | phenethylamine:oxygen oxidoreductase (deaminating) |
R03369 | 3-(2-hydroxyphenyl)propanoate,NADH2:oxygen oxidoreductase(3-hydroxylating) |
R03709 | 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase |
R04376 | 3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing) |
R05487 | phenylacetate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating) |
R05841 | phenylacetyl-CoA:glycine N-phenylacetyltransferase |
R06782 | 3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) |
R06783 | trans-cinnamate,NADH:oxygen oxidoreductase (2,3-hydroxylating) |
R06784 | 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase |
R06785 | (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate:NAD+ oxidoreductase |
R06786 | 3-(3-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (2-hydroxylating) |
R06787 | (2E)-3-(3-hydroxyphenyl)prop-2-enoate,NADH:oxygen oxidoreductase (2-hydroxylating) |
R06788 | (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate:oxygen 1,2-oxidoreductase (decyclizing) |
R06789 | (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate fumarylhydrolase |
R06941 | (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase |
R06942 | (3S)-3-hydroxyacyl-CoA hydro-lyase |
R07222 | phenylacetyl-CoA:quinone oxidoreductase |
R07294 | phenylglyoxylyl-CoA hydrolase |
R09820 | 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde:NADP+ oxidoreductase |
R09836 | 2-oxepin-2(3H)-ylideneacetyl-CoA hydrolyase |
R09837 | 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase |
R09838 | phenylacetyl-CoA:oxygen oxidoreductase (1,2-epoxidizing) |
R09839 | 2,3-didehydroadipoyl-CoA:acetyl-CoA C-didehydroadipoyltransferase (double bond migration) |
R11918 | L-phenylalanine carboxy-lyase (oxidative-deaminating) |
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Compound |
C00596 | 2-Hydroxy-2,4-pentadienoate |
C01198 | 3-(2-Hydroxyphenyl)propanoate |
C01772 | trans-2-Hydroxycinnamate |
C02137 | alpha-Oxo-benzeneacetic acid |
C02763 | 2-Hydroxy-3-phenylpropenoate |
C03519 | N-Acetyl-L-phenylalanine |
C03589 | 4-Hydroxy-2-oxopentanoate |
C04044 | 3-(2,3-Dihydroxyphenyl)propanoate |
C04479 | 2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate |
C06207 | 2,6-Dihydroxyphenylacetate |
C11457 | 3-(3-Hydroxyphenyl)propanoic acid |
C11588 | cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol |
C12621 | trans-3-Hydroxycinnamate |
C12622 | cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol |
C12623 | trans-2,3-Dihydroxycinnamate |
C12624 | 2-Hydroxy-6-ketononatrienedioate |
C14144 | 5-Carboxy-2-pentenoyl-CoA |
C14145 | (3S)-3-Hydroxyadipyl-CoA |
C19945 | 3-Oxo-5,6-dehydrosuberyl-CoA |
C19946 | 3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde |
C19975 | 2-Oxepin-2(3H)-ylideneacetyl-CoA |
C20062 | 2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA |
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Reference |
|
Authors |
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds). |
Title |
[Cellular Functions and Metabolic Maps] (In Japanese) |
Journal |
Tokyo Kagaku Dojin (1997) |
Reference |
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Authors |
Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T. |
Title |
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441. |
Journal |
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Reference |
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Authors |
Diaz E, Ferrandez A, Garcia JL. |
Title |
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12. |
Journal |
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Reference |
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Authors |
Ferrandez A, Garcia JL, Diaz E. |
Title |
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12. |
Journal |
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Reference |
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Authors |
Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG |
Title |
Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway. |
Journal |
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Reference |
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Authors |
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G |
Title |
Bacterial phenylalanine and phenylacetate catabolic pathway revealed. |
Journal |
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Related pathway |
rn00010 | Glycolysis / Gluconeogenesis |
rn00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
rn00960 | Tropane, piperidine and pyridine alkaloid biosynthesis |
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KO pathway |
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LinkDB |
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