PATHWAY: rn00591 Help
Entry
Name
Linoleic acid metabolism
Class
Metabolism; Lipid metabolism
Pathway map
Ortholog table
Other DBs
Reaction
R03626 linoleate:oxygen 13-oxidoreductase
R03627 9-cis,12-cis-octadecadienoate delta12-cis-delta11-trans-isomerase
R05718 linoleate:oxygen 11S-oxidoreductase
R05740 linoleate,ferrocytochrome-b5:oxygen oxidoreductase (12,13-dehydrogenating)
R07057 linoleate:oxygen 9-oxidoreductase
R07058 13-HODE:NAD+ oxidoreductase
R07061 linoleate:oxygen (8R)-oxidoreductase
R07062 (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase [(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate-forming]
R07063 linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase
R07064 phosphatidylcholine 2-acylhydrolase
R09811 linoleate:oxygen (10R)-oxidoreductase
R09905 (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase [(5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate-forming]
R13321 (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate lyase
Compound
C03242 Dihomo-gamma-linolenate
C04717 (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
C06426 (6Z,9Z,12Z)-Octadecatrienoic acid
C07338 (9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid
C14832 12,13-Epoxy-9-hydroxy-10-octadecenoate
C14834 9,10-Epoxy-13-hydroxy-11-octadecenoate
C14836 9,10-12,13-Diepoxyoctadecanoate
C14837 9,10-Dihydroxy-12,13-epoxyoctadecanoate
C19937 (8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate
C22918 (9Z,11E)-12-[(1E)-Hex-1-en-1-yloxy]dodeca-9,11-dienoic acid
Reference
Authors
Nowak G, Grant DF, Moran JH.
Title
Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.
Journal
Reference
Authors
Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM.
Title
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
Journal
Reference
Authors
Spiteller G.
Title
Do changes in the cell membrane structure induce the generation of lipid peroxidation products which serve as first signalling molecules in cell to cell communication?
Journal
Reference
Authors
Jude AR, Little JM, Bull AW, Podgorski I, Radominska-Pandya A.
Title
13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases.
Journal
Drug Metab Dispos 29:652-5 (2001)
Reference
Authors
Su C, Sahlin M, Oliw EH.
Title
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
Journal
Reference
Authors
Brodowsky ID, Hamberg M, Oliw EH.
Title
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid.
Journal
J Biol Chem 267:14738-45 (1992)
Reference
Authors
Hamberg M, Hamberg G.
Title
Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).
Journal
Reference
Authors
Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD.
Title
Novel metabolic pathways for linoleic and arachidonic acid metabolism.
Journal
Related pathway
rn00590 Arachidonic acid metabolism
KO pathway
LinkDB
All DBs