KEGG   PATHWAY: sce00750
Entry
sce00750                    Pathway                                
Name
Vitamin B6 metabolism - Saccharomyces cerevisiae (budding yeast)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
sce00750  Vitamin B6 metabolism
sce00750

Module
sce_M00916  Pyridoxal-P biosynthesis, R5P + glyceraldehyde-3P + glutamine => pyridoxal-P [PATH:sce00750]
Other DBs
GO: 0042816
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YBR035C  PDX3; pyridoxamine-phosphate oxidase PDX3 [KO:K00275] [EC:1.4.3.5]
YGR017W  uncharacterized protein [KO:K00275] [EC:1.4.3.5]
YNR027W  BUD17; putative pyridoxal kinase BUD17 [KO:K00868] [EC:2.7.1.35]
YEL029C  BUD16; putative pyridoxal kinase BUD16 [KO:K00868] [EC:2.7.1.35]
YPR127W  pyridoxine 4-dehydrogenase [KO:K05275] [EC:1.1.1.65]
YOR184W  SER1; O-phospho-L-serine:2-oxoglutarate transaminase [KO:K00831] [EC:2.6.1.52]
YCR053W  THR4; threonine synthase THR4 [KO:K01733] [EC:4.2.3.1]
YMR096W  SNZ1; pyridoxine biosynthesis protein SNZ1 [KO:K06215] [EC:4.3.3.6]
YFL059W  SNZ3; pyridoxine biosynthesis protein SNZ3 [KO:K06215] [EC:4.3.3.6]
YNL333W  SNZ2; pyridoxine biosynthesis protein SNZ2 [KO:K06215] [EC:4.3.3.6]
YMR095C  SNO1; putative pyridoxal 5'-phosphate synthase [KO:K08681] [EC:4.3.3.6]
YFL060C  SNO3; putative pyridoxal 5'-phosphate synthase [KO:K08681] [EC:4.3.3.6]
YNL334C  SNO2; putative pyridoxal 5'-phosphate synthase [KO:K08681] [EC:4.3.3.6]
Compound
C00018  Pyridoxal phosphate
C00064  L-Glutamine
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00232  Succinate semialdehyde
C00250  Pyridoxal
C00266  Glycolaldehyde
C00279  D-Erythrose 4-phosphate
C00314  Pyridoxine
C00534  Pyridoxamine
C00627  Pyridoxine phosphate
C00647  Pyridoxamine phosphate
C00847  4-Pyridoxate
C00971  4-Pyridoxolactone
C01215  2-(Acetamidomethylene)succinate
C01270  3-Hydroxy-2-methylpyridine-5-carboxylate
C03393  4-Phospho-D-erythronate
C04106  2-(Hydroxymethyl)-4-oxobutanoate
C04604  3-Hydroxy-2-methylpyridine-4,5-dicarboxylate
C04690  2-(Hydroxymethyl)-3-(acetamidomethylene)succinate
C04773  3-Hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate
C06050  2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
C06051  Isopyridoxal
C06052  5-Pyridoxolactone
C06054  2-Oxo-3-hydroxy-4-phosphobutanoate
C06055  O-Phospho-4-hydroxy-L-threonine
C06056  4-Hydroxy-L-threonine
C07335  2-Amino-3-oxo-4-phosphonooxybutyrate
C11638  3-Amino-2-oxopropyl phosphate
Reference
PMID:10753941
  Authors
Tazoe M, Ichikawa K, Hoshino T.
  Title
Biosynthesis of vitamin B(6) in rhizobium.
  Journal
J Biol Chem 275:11300-5 (2000)
DOI:10.1074/jbc.275.15.11300
Reference
PMID:9696782
  Authors
Yang Y, Zhao G, Man TK, Winkler ME.
  Title
Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12.
  Journal
J Bacteriol 180:4294-9 (1998)
DOI:10.1128/JB.180.16.4294-4299.1998
Reference
PMID:12269807
  Authors
Yeh JI, Du S, Pohl E, Cane DE.
  Title
Multistate binding in pyridoxine 5'-phosphate synthase: 1.96 A crystal structure in complex with 1-deoxy-D-xylulose phosphate.
  Journal
Biochemistry 41:11649-57 (2002)
DOI:10.1021/bi026292t
Reference
PMID:10225425
  Authors
Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS.
  Title
Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein.
  Journal
FEBS Lett 449:45-8 (1999)
DOI:10.1016/S0014-5793(99)00393-2
Reference
PMID:16157873
  Authors
Tambasco-Studart M, Titiz O, Raschle T, Forster G, Amrhein N, Fitzpatrick TB.
  Title
Vitamin B6 biosynthesis in higher plants.
  Journal
Proc Natl Acad Sci U S A 102:13687-92 (2005)
DOI:10.1073/pnas.0506228102
Reference
PMID:22276911
  Authors
Nagase T, Mugo AN, Chu HN, Yoshikane Y, Ohnishi K, Yagi T
  Title
The mll6786 gene encodes a repressor protein controlling the degradation pathway for vitamin B6 in Mesorhizobium loti.
  Journal
FEMS Microbiol Lett 329:116-22 (2012)
DOI:10.1111/j.1574-6968.2012.02510.x
Related
pathway
sce00010  Glycolysis / Gluconeogenesis
sce00030  Pentose phosphate pathway
sce00630  Glyoxylate and dicarboxylate metabolism
sce00650  Butanoate metabolism
sce00730  Thiamine metabolism
KO pathway
ko00750   
LinkDB

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