KEGG   PATHWAY: sku01210
Entry
sku01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Sulfuricurvum kujiense
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
sku01210  2-Oxocarboxylic acid metabolism
sku01210

Module
sku_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:sku01210]
sku_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:sku01210]
sku_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:sku01210]
sku_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:sku01210]
sku_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sku01210]
sku_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:sku01210]
Organism
Sulfuricurvum kujiense [GN:sku]
Related
pathway
sku00020  Citrate cycle (TCA cycle)
sku00220  Arginine biosynthesis
sku00250  Alanine, aspartate and glutamate metabolism
sku00260  Glycine, serine and threonine metabolism
sku00270  Cysteine and methionine metabolism
sku00290  Valine, leucine and isoleucine biosynthesis
sku00300  Lysine biosynthesis
sku00620  Pyruvate metabolism
sku00640  Propanoate metabolism
sku00680  Methane metabolism
KO pathway
ko01210   
LinkDB

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