KEGG   Prionailurus bengalensis (leopard cat): 122484410
Entry
122484410         CDS       T07574                                 
Symbol
TPH1
Name
(RefSeq) tryptophan 5-hydroxylase 1
  KO
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]
Organism
pbg  Prionailurus bengalensis (leopard cat)
Pathway
pbg00380  Tryptophan metabolism
pbg00790  Folate biosynthesis
pbg01100  Metabolic pathways
pbg04726  Serotonergic synapse
Module
pbg_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
Brite
KEGG Orthology (KO) [BR:pbg00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    122484410 (TPH1)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    122484410 (TPH1)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    122484410 (TPH1)
Enzymes [BR:pbg01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4  tryptophan 5-monooxygenase
     122484410 (TPH1)
SSDB
Motif
Pfam: Biopterin_H ACT TH_ACT ACT_4 zf-C2HE DUF262
Other DBs
NCBI-GeneID: 122484410
NCBI-ProteinID: XP_043438296
LinkDB
Position
D1:complement(74585021..74610294)
AA seq 527 aa
MHCMPIIFQALLGNVLSYVGLITVLQSISTNPCFTGEETKTWLMLSSIFFGFKYCQIQPL
LHDFSFRPLYFHTLFLEKYTKLIMIEDNKENKDHSLERGRATLIFSLKNEVGGLIKALKI
FQEKHVSLLHIESRKSKRRNSEFEIFIDCDINREQLNDIFHLLKSYTNVLSVNPPDNFTV
REDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKH
GDPIPKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDV
SNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGH
VPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSS
ISELKHSLSGHAKVKPFDPKITCKQECRITTFQDVYFVSESFEDAKEKMREFTKTIKRPF
GVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSKQLSI
NT seq 1584 nt   +upstreamnt  +downstreamnt
atgcattgtatgcctattatattccaggcactgttaggcaatgttttatcttatgttggt
ctcattacagtcttgcaaagcatatctacaaatccatgtttcacaggtgaggaaactaaa
acttggttaatgttatcaagtattttctttggtttcaaatattgtcaaatacagcctctc
ttgcacgacttctcttttagacctctctattttcatactttgtttttagagaagtacacc
aaactcatcatgattgaagacaataaggaaaataaagaccattccctagaaagaggaagg
gcaactctcattttttccttgaagaatgaagttggtggactaataaaagcactgaaaatc
ttccaggagaaacatgtgagcctgttacatattgagtcccgaaaatcaaagagaagaaac
tcagaatttgagatctttattgactgtgatatcaacagagaacaactgaatgatattttt
catctgttgaagtcctacactaacgttctctctgtgaatcccccagataattttactgtg
agagaagacggtatggaaactgttccttggtttccaaagaagatttctgacctggatcat
tgtgccaacagagttctgatgtatggatctgaactggatgcagaccatcctggcttcaaa
gacaatgtctaccgtaaaagacgaaagtattttgcagacttggctatgaactataagcat
ggagaccccattcccaaggttgaattcactgaagaggagattaagacctggggaaccgtg
ttccgagagctgaacaaactttacccaactcatgcctgcagagagtatctcaaaaactta
cctttgctttctaaatattgtggataccgggaagataatatcccacaattggaagatgtc
tcaaactttttaaaagagcgcacaggtttttccatccgtcctgtggctggttacttatca
ccaagagatttcttatcaggtttagcctttcgagtttttcactgcacacagtatgtgaga
cacagttcagaccctctctataccccagagccagatacctgccatgaactcttaggtcat
gtccccctgttggctgaacctagttttgctcaattctcccaagaaattggcctggcttct
cttggagcttcagaggaggctgttcaaaaactggcaacgtgctactttttcactgtggag
tttggtctctgtaaacaagatgggcagttgcgagtctttggtgctggattactttcttcg
atcagtgaacttaaacattcactttctggacatgccaaagtaaagccctttgatcccaag
attacctgcaaacaggagtgtcgcatcacaacttttcaggatgtctactttgtatctgaa
agctttgaagatgcaaaagagaagatgagagaatttaccaaaacaattaagcgtccgttt
ggagtgaagtataatccatatacacggagtattcagatcctgaaagacaccaagagcata
accagtgccatgaatgaactgcagcatgatcttgatgttgtcagtgatgcccttgcgaag
gtcagcaagcagctgagcatctga

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