Puma concolor (puma): 112849881 Help Entry 112849881         CDS       T08890                                  Symbol ADCY5 Name (RefSeq) adenylate cyclase type 5   KO K08045   adenylate cyclase 5 [EC:4.6.1.1] Organism pcoo  Puma concolor (puma) Pathway pcoo00230   Purine metabolism pcoo01100   Metabolic pathways pcoo01522   Endocrine resistance pcoo04015   Rap1 signaling pathway pcoo04022   cGMP-PKG signaling pathway pcoo04024   cAMP signaling pathway pcoo04062   Chemokine signaling pathway pcoo04072   Phospholipase D signaling pathway pcoo04114   Oocyte meiosis pcoo04211   Longevity regulating pathway pcoo04213   Longevity regulating pathway - multiple species pcoo04261   Adrenergic signaling in cardiomyocytes pcoo04270   Vascular smooth muscle contraction pcoo04371   Apelin signaling pathway pcoo04540   Gap junction pcoo04611   Platelet activation pcoo04713   Circadian entrainment pcoo04714   Thermogenesis pcoo04723   Retrograde endocannabinoid signaling pcoo04724   Glutamatergic synapse pcoo04725   Cholinergic synapse pcoo04726   Serotonergic synapse pcoo04727   GABAergic synapse pcoo04728   Dopaminergic synapse pcoo04750   Inflammatory mediator regulation of TRP channels pcoo04911   Insulin secretion pcoo04912   GnRH signaling pathway pcoo04913   Ovarian steroidogenesis pcoo04914   Progesterone-mediated oocyte maturation pcoo04915   Estrogen signaling pathway pcoo04916   Melanogenesis pcoo04918   Thyroid hormone synthesis pcoo04921   Oxytocin signaling pathway pcoo04923   Regulation of lipolysis in adipocytes pcoo04924   Renin secretion pcoo04925   Aldosterone synthesis and secretion pcoo04926   Relaxin signaling pathway pcoo04927   Cortisol synthesis and secretion pcoo04928   Parathyroid hormone synthesis, secretion and action pcoo04934   Cushing syndrome pcoo04935   Growth hormone synthesis, secretion and action pcoo04970   Salivary secretion pcoo04971   Gastric acid secretion pcoo04972   Pancreatic secretion pcoo04976   Bile secretion pcoo05012   Parkinson disease pcoo05030   Cocaine addiction pcoo05031   Amphetamine addiction pcoo05032   Morphine addiction pcoo05034   Alcoholism pcoo05163   Human cytomegalovirus infection pcoo05166   Human T-cell leukemia virus 1 infection pcoo05200   Pathways in cancer pcoo05207   Chemical carcinogenesis - receptor activation pcoo05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:pcoo00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     112849881 (ADCY5)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     112849881 (ADCY5)    04371 Apelin signaling pathway     112849881 (ADCY5)    04072 Phospholipase D signaling pathway     112849881 (ADCY5)    04024 cAMP signaling pathway     112849881 (ADCY5)    04022 cGMP-PKG signaling pathway     112849881 (ADCY5)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     112849881 (ADCY5)   09144 Cellular community - eukaryotes    04540 Gap junction     112849881 (ADCY5)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     112849881 (ADCY5)    04062 Chemokine signaling pathway     112849881 (ADCY5)   09152 Endocrine system    04911 Insulin secretion     112849881 (ADCY5)    04923 Regulation of lipolysis in adipocytes     112849881 (ADCY5)    04912 GnRH signaling pathway     112849881 (ADCY5)    04913 Ovarian steroidogenesis     112849881 (ADCY5)    04915 Estrogen signaling pathway     112849881 (ADCY5)    04914 Progesterone-mediated oocyte maturation     112849881 (ADCY5)    04921 Oxytocin signaling pathway     112849881 (ADCY5)    04926 Relaxin signaling pathway     112849881 (ADCY5)    04935 Growth hormone synthesis, secretion and action     112849881 (ADCY5)    04918 Thyroid hormone synthesis     112849881 (ADCY5)    04928 Parathyroid hormone synthesis, secretion and action     112849881 (ADCY5)    04916 Melanogenesis     112849881 (ADCY5)    04924 Renin secretion     112849881 (ADCY5)    04925 Aldosterone synthesis and secretion     112849881 (ADCY5)    04927 Cortisol synthesis and secretion     112849881 (ADCY5)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     112849881 (ADCY5)    04270 Vascular smooth muscle contraction     112849881 (ADCY5)   09154 Digestive system    04970 Salivary secretion     112849881 (ADCY5)    04971 Gastric acid secretion     112849881 (ADCY5)    04972 Pancreatic secretion     112849881 (ADCY5)    04976 Bile secretion     112849881 (ADCY5)   09156 Nervous system    04724 Glutamatergic synapse     112849881 (ADCY5)    04727 GABAergic synapse     112849881 (ADCY5)    04725 Cholinergic synapse     112849881 (ADCY5)    04728 Dopaminergic synapse     112849881 (ADCY5)    04726 Serotonergic synapse     112849881 (ADCY5)    04723 Retrograde endocannabinoid signaling     112849881 (ADCY5)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     112849881 (ADCY5)   09149 Aging    04211 Longevity regulating pathway     112849881 (ADCY5)    04213 Longevity regulating pathway - multiple species     112849881 (ADCY5)   09159 Environmental adaptation    04713 Circadian entrainment     112849881 (ADCY5)    04714 Thermogenesis     112849881 (ADCY5)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     112849881 (ADCY5)    05207 Chemical carcinogenesis - receptor activation     112849881 (ADCY5)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     112849881 (ADCY5)    05163 Human cytomegalovirus infection     112849881 (ADCY5)   09164 Neurodegenerative disease    05012 Parkinson disease     112849881 (ADCY5)   09165 Substance dependence    05030 Cocaine addiction     112849881 (ADCY5)    05031 Amphetamine addiction     112849881 (ADCY5)    05032 Morphine addiction     112849881 (ADCY5)    05034 Alcoholism     112849881 (ADCY5)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     112849881 (ADCY5)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     112849881 (ADCY5)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     112849881 (ADCY5) Enzymes [BR:pcoo01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      112849881 (ADCY5) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  AC_N Guanylate_cyc Adcy_cons_dom TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  112849881 NCBI-ProteinID:  XP_025769326 UniProt:  A0A6P6H1P6 LinkDB All DBs Position Unknown AA seq 1121 aa AA seqDB search AAAAAAGGTEVRPRSVELGLEERRSKGRAADELEAGAGAVEGDEGSGDGSSSAGSGAGPG SVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFH AARPPLQLPYLAVLAAAVGVILVMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLP QPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLV SNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHV AMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFAR FDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVN MRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEV EPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPF YNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKF LLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSVFMLSFYLTCFLLL TLVVFVSVIYSCVKLFPAPLQTLSRKIVRSKTNSTLVGVFTITLVFLSAFVNMFMCNSKD LFGCLADEHNISTSQVNACHVVESAVNYSLGDEQGFCSSPRPNCNFPEYFTYSVLLSLLA CSVFLQISCIGKLVLMLAIELTYVLIVEVPRVTLFDNADLLVTANAIDFSNNGTSQCPEH ATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLL HNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLL NEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMD QMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQV TTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS NT seq 3366 nt NT seq  +upstreamnt  +downstreamnt gcggctgcggccgcagctggcgggaccgaggtgcgccctcgctcggtggagctgggcctg gaggagcggcggagcaagggccgcgcggcggacgagctggaggccggtgccggtgccgtc gagggcgacgaagggtcaggggatggcagcagctcggccggctcaggcgcggggcccggc tcagtgctgtcgctgggcgcctgctgcctggcgctgctgcagatattccgctccaagaag ttcccgtcggacaaactggagcggctgtaccagcgctacttcttccgtctgaaccagagc agcctcactatgcttatggccgtgctggtgctcgtgtgcctcgtcatgttggccttccac gcggcacggcccccgctccagctgccctacctggcagtgctggcggccgcggtgggtgtc atccttgtcatggctgtgctctgtaaccgcgccgccttccaccaggaccacatgggcctg gcctgctacgcgctcatcgctgtggtgctggctgtccaggtggtgggcctgctgctgccc cagccgcgcagcgcctcggagggcatctggtggaccgtgttcttcatctacaccatctac acgttgctgcctgtgcgcatgcgggccgcggtactcagtggggtgctgctgtctgccctc cacctggccatcgccctgcgcaccaacgcccaggaccagttcctgctcaagcagcttgtt tccaatgtcctcattttctcctgcaccaacattgtgggtgtctgcacccactacccggct gaggtctctcagagacaggccttccaggaaacccgggagtgcatccaggcacggctccac tcacaacgggagaaccagcaacaggagcggctcctgctgtctgtcctgccccgtcatgtt gccatggagatgaaagcagacatcaatgccaagcaggaggatatgatgttccataagatt tacatccagaaacatgacaacgtgagcatcctgtttgctgacatcgagggcttcaccagc ctggcatcccagtgcactgcccaggagctagtcatgaccctcaacgagctcttcgcccgc ttcgacaagctggctgcggagaatcactgtttacgtattaagatcctgggggattgttat tactgtgtctctgggctgcctgaagcgagggctgaccacgctcactgctgcgtggagatg ggcatggacatgattgaggccatctcgttggtccgggaggtgactggggtgaacgtgaac atgcgcgtgggaattcacagcgggcgagtacactgcggtgtccttggtctcaggaagtgg cagttcgacgtctggtctaatgacgtcacgctggccaaccacatggaagctggaggcaag gcagggcgcatccacatcaccaaggccacactcaactacctgaatggtgactacgaggtg gagccaggctgtgggggcgagcgcaacgcctacctcaaggagcacagcattgagaccttc ctcatcctgcgctgcacccagaagcggaaagaagaaaaggccatgatcgccaagatgaat cgtcagagaaccaactccattgggcacaacccgcctcactggggggctgagcgtcccttc tacaaccacctagggggcaaccaggtgtccaaggagatgaagcggatgggctttgaagac cccaaggacaagaacgcccaggaaagtgcaaaccccgaggatgaagtggacgaatttctg ggccgtgccattgacgccaggagcatcgacaggctgcggtctgagcatgtccgcaagttc ctcttgaccttcagggagcctgacttagagaagaagtactccaagcaggtggatgaccga ttcggtgcctatgtggcatgtgcctcgcttgtcttcctcttcatctgctttgtccagatc accatcgtgccccactccgtgttcatgttgagtttctacctgacctgtttcctgctgctg accttggtggtgtttgtgtccgtgatttattcctgcgtgaagctcttcccggccccgctg cagaccctttccaggaagatcgtgcggtccaagacgaacagcaccctggtcggagtgttc accatcaccctggtgttcctgtcggcttttgtcaacatgttcatgtgtaactccaaggac ctgtttggctgcctggcggacgagcacaacatcagcaccagccaggtcaacgcgtgccat gtggtggagtcggcagtcaactacagcctgggtgacgagcagggcttctgcagcagcccc cggcccaactgcaacttccccgagtacttcacctacagcgtgctgctcagcctgctggcc tgctccgtgttcctgcagatcagctgcattgggaagctggtgctcatgctggccattgag ctcacatacgtgctcattgttgaggtgccccgcgtcaccctctttgacaacgccgacctg ctggtcaccgccaacgccatagacttcagcaacaacgggacctcccagtgccctgagcat gcgaccaaggtggcgctgaaagtggtgacgcccatcatcatctcagtcttcgtgctggcc ctgtacctgcacgcccagcaagtagagtccaccgcccgcctggacttcctctggaaactg caggccacggaggaaaaggaggagatggaggagctgcaggcctacaaccggcggctgctg cacaacatcctgcccaaggatgtggccgcccacttcctggcccgcgagcgacgcaatgat gagctctactaccagtcgtgtgagtgcgtggccgtcatgttcgcctccatcgccaacttc tctgagttctacgttgagctggaggccaacaatgagggtgttgagtgcctgcgactactc aatgagatcatcgccgactttgacgagatcatcagcgaggatcggttcaggcagctggaa aagatcaagaccattggcagcacctacatggctgcctcaggcctcaatgactctacatat gacaaggtgggcaagacccacatcaaagccctggctgactttgccatgaagctcatggac caaatgaagtacatcaatgagcactccttcaacaacttccagatgaagatcgggctcaat attggccccgtggtggctggggtgatcggggctcgcaagcctcagtacgacatctggggc aatacggtgaacgtggccagccgcatggacagcaccggtgtgcctgaccgcatccaggtc accacagacatgtaccaggtgctggctgccaacacataccagctggagtgcaggggcgtg gtcaaggtcaagggcaaaggagagatgatgacctacttcctcaacggtgggcccccgctc agttag

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