KEGG   Puma concolor (puma): 112871680
Entry
112871680         CDS       T08890                                 
Symbol
PDHA1
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X1
  KO
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
Organism
pcoo  Puma concolor (puma)
Pathway
pcoo00010  Glycolysis / Gluconeogenesis
pcoo00020  Citrate cycle (TCA cycle)
pcoo00620  Pyruvate metabolism
pcoo00785  Lipoic acid metabolism
pcoo01100  Metabolic pathways
pcoo01200  Carbon metabolism
pcoo01210  2-Oxocarboxylic acid metabolism
pcoo04066  HIF-1 signaling pathway
pcoo04922  Glucagon signaling pathway
pcoo05230  Central carbon metabolism in cancer
pcoo05415  Diabetic cardiomyopathy
Module
pcoo_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:pcoo00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    112871680 (PDHA1)
   00020 Citrate cycle (TCA cycle)
    112871680 (PDHA1)
   00620 Pyruvate metabolism
    112871680 (PDHA1)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    112871680 (PDHA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    112871680 (PDHA1)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    112871680 (PDHA1)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    112871680 (PDHA1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    112871680 (PDHA1)
Enzymes [BR:pcoo01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1  pyruvate dehydrogenase (acetyl-transferring)
     112871680 (PDHA1)
SSDB
Motif
Pfam: E1_dh DXP_synthase_N TPP_enzyme_C
Other DBs
NCBI-GeneID: 112871680
NCBI-ProteinID: XP_025790499
UniProt: A0A6P6IRS3
LinkDB
Position
Unknown
AA seq 397 aa
MRKMLAAVSRVLSGVAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQLLLLLMQEACCVGLEAGINPTDH
LITAYRAHGFTFTRGLSVREILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPL
GAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSV
ERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHS
MSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFA
TADPEPPLEELGHHIYSSDPPFEVRGANQWIKFKSIS
NT seq 1194 nt   +upstreamnt  +downstreamnt
atgaggaaaatgctcgcagctgtctcccgcgtgttgtcgggcgtcgcccagaagccggca
agcagagtgctggtggcatcccgtaattttgcaaatgatgctacgtttgaaattaagaaa
tgtgatcttcaccgactggaagagggccctcctgtcaccacggtactcaccagggaggat
gggctcaaatactataggatgatgcagactgttcgccgaatggaattaaaggcagatcag
ctgtataaacagaaaattattcgtggtttttgtcacttgtgtgatggtcagctgctgctt
cttttaatgcaggaagcttgttgtgtgggcctggaggccggcataaatcccacagaccat
cttatcacagcctatcgggctcatggcttcacctttactcgtggactttctgtccgagaa
attcttgcagagcttacaggacgaagaggaggttgcgctaaagggaaaggcggatcgatg
catatgtatgccaaaaacttctacgggggcaacggcatcgtcggagctcaggtacccctg
ggagcagggattgctctggcctgtaagtataacggaaaggatgaggtctgtttgacttta
tatggcgatggtgctgctaaccaaggtcagatattcgaagcttacaatatggcagctttg
tggaaattgccatgtattttcatctgtgaaaataaccgctatggaatgggaacatctgtt
gagagagcagcggccagcacggattactacaagagaggtgacttcattcctgggctgagg
gtagatggaatggatatcctgtgtgtccgggaggcgacgaggtttgcagccgcctactgt
agatctggaaaggggcccatactgatggagctacagacttaccgctaccacggacatagc
atgagtgaccctggtgtcagttaccgtacacgagaggagattcaggaagtaagaagtaag
agtgaccctattatgcttctcaaggatagaatggtgaacagcaacctggccagtgttgaa
gaattaaaggaaattgatgttgaagtgaggaaagagattgaggatgctgcccagtttgcc
accgctgatcctgaaccgcctttggaagaactaggccatcacatttacagcagcgaccca
ccttttgaagttcggggtgcaaatcagtggatcaagtttaagtccatcagttaa

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