Phascolarctos cinereus (koala): 110199010
Help
Entry
110199010 CDS
T05867
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
pcw
Phascolarctos cinereus (koala)
Pathway
pcw05012
Parkinson disease
pcw05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
pcw00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
110199010 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
110199010 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pcw01001
]
110199010 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
pcw04131
]
110199010 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
pcw04147
]
110199010 (LRRK2)
Enzymes [BR:
pcw01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
110199010 (LRRK2)
Protein kinases [BR:
pcw01001
]
Serine/threonine kinases: TKL group
LRRK family
110199010 (LRRK2)
Membrane trafficking [BR:
pcw04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
110199010 (LRRK2)
Exosome [BR:
pcw04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
110199010 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
COR
Roc
LRR_8
LRR_4
Ras
LRR_9
Ank_2
Arf
nSTAND3
PduV-EutP
T2SSE
SRPRB
AAA_7
Arm
AAA_22
LRR_6
GTP_EFTU
MMR_HSR1
cobW
AAA_16
NACHT
Septin
ABC_tran
FtsK_SpoIIIE
Kdo
TsaE
AAA_29
MobB
AAA_14
Motif
Other DBs
NCBI-GeneID:
110199010
NCBI-ProteinID:
XP_020829344
UniProt:
A0A6P5JE33
LinkDB
All DBs
Position
Unknown
AA seq
2528 aa
AA seq
DB search
MASGCSLGDEEKEEETLKKLVVRLQNVQEGKQIETLIQILEDMLMLTYSDHASKLFQGKN
VHMPLLFVLDSYMRVAGVQQVGWSLLCKLTEICPDIMQSLMGPQDVGKDWEVLGVHQLIL
KMLTVHNANINLSVIGLKALDQLLTSDLMTLQILEEDCSDVFTLIFDAMHTFTSNEEIQR
FGCKILHVLFAKVSEEQLTEFIENNDYMFLLNALKRFNHEEEVVFHVIHSLHSLALPCSN
VEVLMSGNVRCYNIVVEAMKMFSNSEKIQEVACCLLHRLTLDNFFNILVLNEVHEVIVKA
VKKYSENAALQIAALSCLALLTETIILNQDFEEKKKNQEDDEDNKLYWLEASYRALTLHR
KNTDVQEAACWALNNLLMYQSNLHENIGDEDDQYPVHREMLLAMLMHSSSKEVFQAAANA
LSTLSKQNVNVRKALLSKGIYWNVLLLMMKHLHFTEVAESGCKMLNHLLEGSNLHLDVMA
SVTSNIIKIMKSHKTSSTVQLEALQTILHIIVPEPKKEPEEDALLNINLKVVKNQCLLND
IHKLVLDALNKFIGNPGIQICGLKIISSLANCSGALEMFSQQGALDSILHTLQMYPVDRV
IQCLGLSLVGCLITKKNLCTETQDLLANILVSSLQRFKDVIEIQISGFQTTLAILELSLG
FAKLLLSHYSYDSLIFYQMSRCFTEQRDHQFQNLCCKYFAKITCDDDVKNVLLGRACEQN
NSVMAECLLLLGADINKVTGKTSLICQVCEKESSPKLVELLLNNGSREQDIRKALMISIK
KNNSEIISLLLRKLGLDLANNSICLGGFCIGKIEPSWLSPLFPDKVSNLRKQTNTGSALA
RMVLRYQMKSLAEDGPISDSDGSFPEDDLDKISDWTVIPESSVDCVFGYSDDVDSEGSES
SFLTKKKSSSFNVGDLYRDPAFQRGSPTLERHSNSMEVSSDCEELLKQTRDLFSSDDSIQ
GSSKFQSHLRQSDSFFTLTSEREYIKSLDLSANELEEIDGISKKCCLSDHLTRLEKLELH
QNALTRVPQQLCEILKCLTYLDLHSNKITSIPDYLLKMNCIANLDISRNNIGPSIILDPN
IKCPTLKQLNLSYNQLSSVPEFLADVIENLEQLLLEGNKISEIYSPLCLKELKILNLSKN
HILSITEDFLEACNKLEVFSARMNLLVAVPCLPSSITTLNLSQNKFTCIPDIILRLPHLR
SVDLSSNEIHNLPGPAHWKSLNLRELLFNHNQISILDLSEKAYMWSRMEKLHLSHNKLKE
IPPEIGFLENLTSLDVSYNLELRSFPNEMGKLTKIWDLPLDELHLNFDFKHIGCKTRDII
RFLQQRLKKAVPYNRMKLMVVGNTGSGKTTLLQQLMKYKRTDLSTPSTTIGIDVKDWSIQ
LRNKGKKELILNVWDFSGREEFYSTHPHFMTQRALYLAVYDLSKGHAEVDAMKPWLFNIK
ARASSSPVILVGTHLDVSDEKQRKASISKITKELLNKRGFPEIRDYHCVNATAECEALVK
LRKSIIKESLNFKIRDQPVVGQLIPDCYLELEKKILLERKNVPTEFPVISQKRLVQLVKE
SQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKMMAQILTVKVEGFA
KYPKGIIQRSDVEKFLSKKSRFPKNYMSQYFKLLEKFQIALPIGEEHLLVPSSLSDQRPV
VELPHCENSEVIVRLYEMPYFPMGFWSRLINRLLEISPYILSGRERALRPNRMYWRQGIY
LNWSPEAYCLVESSVFDNSSESFLKITAPSCRKGCIILGQVVDHIDSVMEEWFPGLLEID
VCGEGETLLKKWALYSFNDGEAQQKILLDDLMKKTEEGDLLINPDQPRLTIPISHIAPDL
TLADLPRNIMLNNDELEFEQAPEFLLGDGCFGSVYRASYKGEEVAVKIFNKHTSLRLLRQ
ELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDQLLQQDKASLTRTLQHRIALHVA
DGLRYLHASMIIYRDLKPHNVLLFTLYPNSAIIAKIADYGIAQYCCRMGIKTSEGTAGFR
APEVARGNVIYNQQADVYSFGLLLYDILTTGGRILEGLKFPNEFDELAIHGRLPDPVKEY
GCTPWPKVENLIKKCLKENPEERPTSAQVYEILNSAELICLMRYILIPKIFVAECMVATH
QSSKNAVIWLGSGNNDAGQLSCLEINTERHISKDMTESRILCLALVYLLVEKESWIVAGT
QSGTLLAVKTEDDKKSHILQRMTDSVTCLYCNSFSKQSKQKNFLLVGTANGRLAIFEDRN
VKFEGAAPLKTLNIGNVNTPLMCLNESIYSSEKNIIWGGCGTKIFSLSNDFFIQKLIETK
TNQLFSYATFSDSNIISIVVDKAIYVAKKNSHFVEVWDKKTEKLCVLIDCVQFLKEHTVI
LSKESKHEMTYSGRVKTLCLQKNTALWIGTGGGHILLVDLSTHRIIHIIQNFCNSIRALM
TVQLGSLKNVMLVLGYCQKSNESTQAQKEVESCLSIWDINLPHEVENLEKHTEVRKELAE
KMKSISME
NT seq
7587 nt
NT seq
+upstream
nt +downstream
nt
atggccagtgggtgcagcctcggggatgaagaaaaagaagaggaaactctgaagaagttg
gtagttaggctgcaaaatgtccaagaaggaaaacagatagaaaccctgatccagatccta
gaggatatgctgatgttaacgtactctgatcacgcttccaagttatttcaaggcaaaaat
gtccatatgcctttgctatttgttttggattcctacatgagagtcgcaggtgtgcaacag
gtgggttggtcacttctttgtaaattgacagaaatttgccctgatataatgcaaagctta
atgggtccccaggatgttggaaaggattgggaagtccttggtgttcatcagctgattctt
aaaatgctcactgttcacaatgctaatataaacctttcagtgattggactgaaggcatta
gatcagctgctgacttcagatttgatgactctgcagatattggaagaagattgcagtgat
gtattcacattaatttttgatgccatgcatacatttaccagcaatgaagagatccaaagg
tttggctgtaaaattttacatgtgctttttgcgaaagtttcagaagagcagctgactgaa
tttattgagaacaatgattatatgtttttgctgaatgcattaaaaagatttaatcatgaa
gaagaagttgtttttcatgttattcacagtttacattccctagcactcccatgcagtaat
gtcgaagtcctaatgagtggaaatgtcagatgttacaatattgtggtagaagccatgaaa
atgttctctaacagtgaaaaaattcaagaagttgcttgctgtttgttacacaggcttaca
ttggataatttctttaatatcctggttttaaatgaggttcatgaggtcattgtgaaagct
gttaaaaaatattcagaaaatgcagccttacagatcgcagcactaagctgtttggctctc
ctcactgaaactattattttaaaccaagattttgaagaaaagaaaaagaatcaggaagat
gatgaggacaataaattatactggctagaagccagttacagagcattgacattgcataga
aagaacacagatgtgcaggaggctgcatgctgggctttgaacaatctacttatgtaccaa
agcaatttacatgaaaatattggagatgaagatgaccagtatccagtacatagggaaatg
ctgcttgccatgctgatgcattcttcatcaaaagaagtatttcaggcggctgctaatgca
ttgtcaactctatcaaaacaaaatgttaatgtcagaaaagccctgttgtcaaaaggaata
tactggaatgtactgctattaatgatgaagcatttacacttcactgaagtggctgaaagt
ggatgcaaaatgttaaatcatcttttggaaggaagtaaccttcacctagatgtaatggca
tcagtgacatctaacataataaaaattatgaaaagtcacaaaacctcatcaacagtgcag
ctggaggcacttcaaactattttacatatcattgtcccagaaccaaagaaagaacctgag
gaagatgctttattaaatataaatttgaaagtggttaaaaaccaatgcctattgaatgac
attcacaaactggttctggatgctttaaataagtttattggaaatcctggaattcaaata
tgtggattaaaaataatttcttctttagcaaattgttctggtgccttagaaatgttttct
cagcaaggggcccttgattccatacttcatacactacagatgtatccagttgacagagta
attcagtgccttggtttaagtctagtaggatgtttgattacaaaaaagaatttgtgcaca
gaaactcaggatctgcttgcaaacattctggtttccagcttacaacgatttaaggatgtc
attgaaatacagataagtggatttcaaacgactttggcaatacttgaattatcacttggc
tttgcaaagttgctgctaagtcattattcatatgactcactaattttctatcagatgtcc
aggtgttttactgaacaaagggatcatcagtttcagaatctttgttgcaaatactttgcc
aaaataacttgtgatgatgatgttaaaaatgtactactggggagagcctgtgagcaaaac
aatagtgttatggctgaatgcctcctgcttttgggagctgatattaataaagtgactgga
aaaacttctttaatctgccaggtttgtgaaaaagaaagcagtcccaaattagtggaactc
ttgttaaataatggatcgagggaacaggatattcgtaaggcattgatgatcagcataaag
aaaaataatagtgaaatcatcagtttactgttaaggaagcttggcctggatcttgccaat
aacagcatttgtcttggagggttttgtattggaaaaattgaaccttcatggcttagtcct
ttatttccggataaagtatcgaatttaagaaaacaaacaaacacaggatctgcattggca
agaatggtactaagatatcaaatgaaaagtttagcagaagatggaccaatatcagacagt
gatggaagttttcctgaagatgaccttgataaaattagtgattggactgtcatacctgag
tcttctgtagactgtgtatttggttacagtgatgatgttgatagtgaaggaagtgaaagt
tcatttcttacgaaaaagaaatcgagctcatttaatgtgggagatctttatagagatcct
gccttccagcggggttcaccaactttggaaaggcattccaattcaatggaggtcagttct
gattgtgaagaattgttgaagcaaacaagagacttattttcttcagatgattctatccaa
ggatcttcaaaattccagtcccatttgagacaatcagacagcttttttactctaacttca
gaaagagaatatataaagtcattagacctttcagcaaatgaactagaggaaattgatggt
ataagcaagaaatgctgtttaagtgatcacttaacacgtcttgagaaactggaacttcac
cagaatgcacttacaagagttccacagcaactctgtgaaattttaaaatgtttgacatat
ttggacttacacagtaacaaaatcacttcaattcctgactatttgttgaaaatgaattgc
attgcaaatcttgatatttcccgtaataatattggaccttctataattttggatccaaat
atcaaatgtccaaccttgaagcagctcaatctctcatacaatcaactatcctctgtccct
gaatttcttgcagatgtcatagaaaatctagaacaactccttctggaaggaaacaaaata
tcagaaatatattcacctttgtgcttgaaggagttgaagattttaaaccttagtaaaaac
cacatattatccataactgaagattttcttgaggcatgtaataaactggaagtttttagt
gccagaatgaatttgcttgttgctgtgccttgcttgccctctagcataacaactttaaat
ttgtcacaaaacaaatttacatgtattccagacatcattctcagacttccacatttacgg
tcagtagatttgagcagcaatgaaattcacaacctgcctgggcctgcacactggaaatca
ttaaatttaagggaacttttgtttaatcataatcagatcagcattttggacttaagtgaa
aaagcatatatgtggtcacggatggaaaaactacacttgtcccataataaattgaaggag
attcctcctgaaattggttttcttgaaaatttaacatctcttgatgtgagttacaatttg
gagctgagatcttttcctaatgaaatggggaagttaactaaaatctgggaccttcctttg
gatgaattgcatcttaattttgattttaagcatataggatgcaagaccagagacatcata
aggtttcttcaacagaggttgaaaaaggcagtgccctataatcgaatgaaacttatggtt
gtgggaaatactggcagtggaaaaactacattgttgcaacagttaatgaaatataaaaga
acagatttgagtacaccaagtactacaataggcatagatgtaaaagattggtcgatccag
ctgaggaacaaagggaagaaagaactgatactgaatgtctgggatttttcaggacgagaa
gagttctacagcactcaccctcactttatgacacaacgagcattatatcttgctgtatat
gatcttagcaaaggacatgctgaagtagatgctatgaagccgtggctcttcaacattaag
gctcgggcttcttcctcaccagtgattctggttggtacacatttggatgtttctgatgag
aaacagagaaaggcctccataagcaaaataacaaaggagctcttaaacaaaagagggttc
cctgaaatacgcgattaccattgtgtgaacgctacagcagaatgtgaggcattggtaaaa
cttcggaaaagcatcataaaagagagtctgaactttaagatcagagaccagcctgttgta
ggacagctaattccagattgctacttggaactcgaaaaaaaaattttattggaacgaaag
aatgttcccactgaatttccagtaatcagtcagaagcgactggtacagctagtaaaagaa
agtcaactacagctggatgaaaatgaacttcctcatgcagttcacttcctaaatgaatca
ggtgtcctgctacatttccaagacccagcactgcagttaagtgatttgtattttgtggaa
cctaaatggctatgcaaaatgatggcacagattttgacagtgaaagtagaaggctttgct
aaatatcctaagggtattattcagcgttcagatgtggaaaagttcctttcaaagaagagc
agatttcccaagaactacatgtctcagtactttaaactcctggaaaaatttcagattgct
ttaccaataggagaagaacatttgctagttccaagcagtttgtctgatcaaagacctgtg
gtagaacttcctcactgtgaaaattctgaagttattgttaggttgtatgaaatgccttat
tttcctatgggattttggtccagactgatcaatcgattacttgaaatttctccttacata
ctctcaggcagagaacgggcccttcgccctaacagaatgtattggagacaaggcatctac
ctgaattggtctcctgaagcctattgtctggtagaatcttcagttttcgacaacagctca
gagagtttcttgaaaattacagcaccttcatgcagaaaaggctgtattattttgggacaa
gttgtagaccacatagattctgtcatggaagaatggtttcctggtttattggaaatagat
gtctgtggtgaaggagaaacattgttaaagaaatgggccttatatagttttaatgatggt
gaagcgcaacaaaaaatattacttgatgatttaatgaaaaaaactgaagaaggagatctc
ttaattaatccagatcaaccaaggcttactatcccaataagccatattgctcctgattta
actttggctgatctgcctagaaatatcatgttgaataacgatgagttggaatttgaacaa
gcaccagaatttcttttaggtgatggttgttttggatctgtttatcgagcatcttataaa
ggagaagaagtggctgtgaagatttttaataaacatacatcacttcggctattaagacaa
gagctagtagtgctttgccatctccaccaccctagtctgatatctctgcttgctgctggt
attcgtccccggatgttggtaatggaattagcctcaaagggttccctagatcagttgctt
caacaagacaaagctagcttaacccgaacactccagcacaggatagcactacatgttgct
gatggcttaagatatctccatgcatcaatgattatataccgggatctgaagcctcataat
gtactcctttttaccctatatcctaattctgcaattattgccaagattgcagattatgga
attgctcagtactgctgcagaatggggataaagacatctgaaggaacagcaggatttcgt
gcaccagaagttgccagaggaaatgtaatttacaaccaacaggctgatgtttattcattt
ggcttactgctttatgacattttgacaacaggaggtagaattctagaaggattgaaattt
ccaaatgaatttgatgagttagctatacatgggaggttaccagatccagttaaagaatat
ggttgcactccatggcctaaagtagaaaacttaattaagaagtgtctgaaagaaaatcct
gaggaaaggccaacatctgcccaggtatatgaaattttgaactcagctgaattaatatgt
ctaatgagatatattttaatacccaaaatatttgtagcagaatgcatggttgctacacac
caaagcagcaagaatgcagtcatctggctgggtagtgggaacaatgatgcagggcagcta
tcctgtcttgaaataaatactgaaagacatatctctaaggatatgacagagagtagaata
ttgtgccttgcccttgtatatcttctggttgaaaaggaaagttggattgtggcaggaaca
cagtctggcaccctattggcagtcaagacagaagatgataaaaagagccacatacttcaa
agaatgactgactctgttacttgtttgtactgcaattctttttctaagcaaagcaaacaa
aagaattttcttttggtgggaactgcaaatggcagactagccatttttgaagacagaaat
gttaagtttgaaggagcagctcctttgaagacattaaatataggaaatgtcaacactcca
ctaatgtgtttaaatgaatccatatattcatcagaaaaaaatataatctggggaggatgt
ggcaccaagattttctcactttctaatgatttcttcattcagaaacttattgagacaaag
acaaatcaactgttttcttatgcaacattcagtgattccaacatcatttcaattgtggtg
gacaaagctatctatgtagctaagaaaaacagccattttgttgaagtatgggataagaag
acggagaaactttgtgtactaatagactgtgtgcagtttttaaaggagcatacagtaata
ttaagcaaggaatcaaaacatgaaatgacttattctggaagagtgaaaaccctctgtctg
cagaaaaatactgcactctggataggtacaggaggaggtcacattttactggttgatctt
tcaacacatcgcatcatacacataattcagaacttttgtaattctattagagcgctgatg
acagtccaattagggagcctaaaaaatgtcatgctggttttggggtactgccagaaaagt
aatgaaagtactcaggcccaaaaagaagtggagtcttgtttatctatatgggacattaac
ctaccacatgaggtggaaaacttggagaagcatacagaagttagaaaagaattagctgaa
aaaatgaaaagtatttccatggagtaa
DBGET
integrated database retrieval system
