KEGG   Phascolarctos cinereus (koala): 110205921
Entry
110205921         CDS       T05867                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
pcw  Phascolarctos cinereus (koala)
Pathway
pcw01522  Endocrine resistance
pcw04010  MAPK signaling pathway
pcw04015  Rap1 signaling pathway
pcw04068  FoxO signaling pathway
pcw04071  Sphingolipid signaling pathway
pcw04114  Oocyte meiosis
pcw04148  Efferocytosis
pcw04218  Cellular senescence
pcw04261  Adrenergic signaling in cardiomyocytes
pcw04370  VEGF signaling pathway
pcw04380  Osteoclast differentiation
pcw04550  Signaling pathways regulating pluripotency of stem cells
pcw04611  Platelet activation
pcw04613  Neutrophil extracellular trap formation
pcw04620  Toll-like receptor signaling pathway
pcw04621  NOD-like receptor signaling pathway
pcw04622  RIG-I-like receptor signaling pathway
pcw04625  C-type lectin receptor signaling pathway
pcw04657  IL-17 signaling pathway
pcw04658  Th1 and Th2 cell differentiation
pcw04659  Th17 cell differentiation
pcw04660  T cell receptor signaling pathway
pcw04664  Fc epsilon RI signaling pathway
pcw04668  TNF signaling pathway
pcw04670  Leukocyte transendothelial migration
pcw04714  Thermogenesis
pcw04722  Neurotrophin signaling pathway
pcw04723  Retrograde endocannabinoid signaling
pcw04728  Dopaminergic synapse
pcw04750  Inflammatory mediator regulation of TRP channels
pcw04912  GnRH signaling pathway
pcw04914  Progesterone-mediated oocyte maturation
pcw04917  Prolactin signaling pathway
pcw04926  Relaxin signaling pathway
pcw04932  Non-alcoholic fatty liver disease
pcw04933  AGE-RAGE signaling pathway in diabetic complications
pcw04935  Growth hormone synthesis, secretion and action
pcw04936  Alcoholic liver disease
pcw05014  Amyotrophic lateral sclerosis
pcw05020  Prion disease
pcw05022  Pathways of neurodegeneration - multiple diseases
pcw05132  Salmonella infection
pcw05133  Pertussis
pcw05135  Yersinia infection
pcw05140  Leishmaniasis
pcw05142  Chagas disease
pcw05145  Toxoplasmosis
pcw05152  Tuberculosis
pcw05161  Hepatitis B
pcw05163  Human cytomegalovirus infection
pcw05167  Kaposi sarcoma-associated herpesvirus infection
pcw05169  Epstein-Barr virus infection
pcw05170  Human immunodeficiency virus 1 infection
pcw05171  Coronavirus disease - COVID-19
pcw05205  Proteoglycans in cancer
pcw05208  Chemical carcinogenesis - reactive oxygen species
pcw05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pcw05415  Diabetic cardiomyopathy
pcw05417  Lipid and atherosclerosis
pcw05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pcw00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    110205921 (MAPK12)
   04015 Rap1 signaling pathway
    110205921 (MAPK12)
   04370 VEGF signaling pathway
    110205921 (MAPK12)
   04668 TNF signaling pathway
    110205921 (MAPK12)
   04068 FoxO signaling pathway
    110205921 (MAPK12)
   04071 Sphingolipid signaling pathway
    110205921 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    110205921 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    110205921 (MAPK12)
   04218 Cellular senescence
    110205921 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    110205921 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110205921 (MAPK12)
   04613 Neutrophil extracellular trap formation
    110205921 (MAPK12)
   04620 Toll-like receptor signaling pathway
    110205921 (MAPK12)
   04621 NOD-like receptor signaling pathway
    110205921 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    110205921 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    110205921 (MAPK12)
   04660 T cell receptor signaling pathway
    110205921 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    110205921 (MAPK12)
   04659 Th17 cell differentiation
    110205921 (MAPK12)
   04657 IL-17 signaling pathway
    110205921 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    110205921 (MAPK12)
   04670 Leukocyte transendothelial migration
    110205921 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    110205921 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    110205921 (MAPK12)
   04917 Prolactin signaling pathway
    110205921 (MAPK12)
   04926 Relaxin signaling pathway
    110205921 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    110205921 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    110205921 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    110205921 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    110205921 (MAPK12)
   04722 Neurotrophin signaling pathway
    110205921 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    110205921 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    110205921 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    110205921 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    110205921 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    110205921 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110205921 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    110205921 (MAPK12)
   05161 Hepatitis B
    110205921 (MAPK12)
   05171 Coronavirus disease - COVID-19
    110205921 (MAPK12)
   05163 Human cytomegalovirus infection
    110205921 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110205921 (MAPK12)
   05169 Epstein-Barr virus infection
    110205921 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110205921 (MAPK12)
   05135 Yersinia infection
    110205921 (MAPK12)
   05133 Pertussis
    110205921 (MAPK12)
   05152 Tuberculosis
    110205921 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    110205921 (MAPK12)
   05140 Leishmaniasis
    110205921 (MAPK12)
   05142 Chagas disease
    110205921 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    110205921 (MAPK12)
   05020 Prion disease
    110205921 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    110205921 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110205921 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    110205921 (MAPK12)
   05415 Diabetic cardiomyopathy
    110205921 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    110205921 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    110205921 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    110205921 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    110205921 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcw01001]
    110205921 (MAPK12)
Enzymes [BR:pcw01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     110205921 (MAPK12)
Protein kinases [BR:pcw01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   110205921 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 RIO1 APH Kdo Kinase-like Haspin_kinase FTA2 UvrD_C
Other DBs
NCBI-GeneID: 110205921
NCBI-ProteinID: XP_020838538
UniProt: A0A6P5K036
LinkDB
Position
Unknown
AA seq 388 aa
MSSPPPPRKGFYRQEVTKTEWEVRELYRDLQPVGSGAYGAVCSAIDSRTGTKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDDTLDDFTDFYLVMPFMGTDLSKLM
KHEKLSDDRIQFLVYQILRGLKYIHAAGIVHRDLKPGNLAVNEDCELKILDFGLARQTDS
EMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMITGKILFKGSDHLDQLMEIMK
VTGTPPPEFVQRLQSQDAKSYMESLPELEKKDFASVLENATPLAVNLLEKMLVLDAEKRV
TAAEALTHPYFETVHESEEEPQAQLYDDSFDDVDRTLEEWNESHTKKFSALSLLGSWIQR
RHLCDWMLRWKEGSLRFRPVGTLMVTPS
NT seq 1167 nt   +upstreamnt  +downstreamnt
atgagctcccctccgcccccccggaagggcttttaccggcaagaggtcactaagactgag
tgggaggtgcgggaactctaccgggacctgcagcccgtgggctcgggggcttacggggcc
gtttgctcggctattgacagcaggacgggcaccaaggtggctatcaagaagctgtaccgt
cccttccagtcggagctgtttgcgaagcgcgcataccgggagctgcgtctactcaaacac
atgcggcacgagaacgtgattggcttgctggatgtcttcacccccgatgacacactggat
gacttcacggacttttacctggttatgccgttcatgggcacagacctcagcaagctgatg
aaacacgagaagcttagtgacgaccggatccaattcttggtctaccagatccttcgaggc
ctcaagtacatccatgccgctggcatcgtccacagggatctcaaacctggtaacctggcc
gtgaatgaggattgtgagctgaagattctggactttggcctggccagacagacagacagt
gagatgacgggctatgtggtgaccagatggtaccgggcacccgaggtcatccttaactgg
atgcattacactcagacagtggatatctggtctgtgggctgcatcatggcagaaatgatc
actgggaagattcttttcaaaggcagcgaccacctggaccagctgatggagatcatgaag
gtgacaggaacgcctcccccagagtttgtacagaggcttcagagtcaggatgcaaagagc
tacatggaaagtctccccgagctggagaagaaggactttgcttctgtcctggagaacgcc
acccccttggctgtgaatctgctggagaagatgttggtactggacgctgagaagcgagtg
acggccgccgaggcgctgacccacccatactttgagactgtgcatgagtccgaggaggag
ccacaggcccagctgtatgatgactcctttgatgatgtcgaccggaccctggaagagtgg
aacgagtcacatacaaagaagttctcagctttaagcctcctcggctcctggattcaaagg
agacatctctgtgactggatgctgagatggaaagaggggtccctcagattcaggccagta
gggactcttatggtgactcctagttga

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