Plasmodium malariae: PMUG01_05034700
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Entry
PMUG01_05034700 CDS
T09444
Symbol
DHFR-TS
Name
(RefSeq) bifunctional dihydrofolate reductase-thymidylate synthase, putative
KO
K13998
dihydrofolate reductase / thymidylate synthase [EC:
1.5.1.3
2.1.1.45
]
Organism
pmal
Plasmodium malariae
Pathway
pmal00240
Pyrimidine metabolism
pmal00670
One carbon pool by folate
pmal00790
Folate biosynthesis
pmal01100
Metabolic pathways
pmal01232
Nucleotide metabolism
pmal01240
Biosynthesis of cofactors
Module
pmal_M00841
Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
pmal_M00938
Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:
pmal00001
]
09100 Metabolism
09104 Nucleotide metabolism
00240 Pyrimidine metabolism
PMUG01_05034700 (DHFR-TS)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
PMUG01_05034700 (DHFR-TS)
00670 One carbon pool by folate
PMUG01_05034700 (DHFR-TS)
Enzymes [BR:
pmal01000
]
1. Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.3 dihydrofolate reductase
PMUG01_05034700 (DHFR-TS)
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.45 thymidylate synthase
PMUG01_05034700 (DHFR-TS)
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Gene cluster
GFIT
Motif
Pfam:
Thymidylat_synt
DHFR_1
Motif
Other DBs
NCBI-GeneID:
39867390
NCBI-ProteinID:
XP_028860494
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All DBs
Position
5:1291853..1293718
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AA seq
621 aa
AA seq
DB search
MEDLADIFDIYAICACCKVPNQGEGKKNEIFSTKTFRGLGNKGCLPWKSNSLDMKYFRSV
TTYVNEMKYKKLKYKREKYLEKEISNENSSTVFENISLLSSSKLQNVVVMGRSNWVSIPK
QYKPLPNRINVVLSRTLKKEDVKEDIFIINNMDQLVLLLKKLNYYKCFIIGGAIVYKECL
ERNLIKQIYFTRINNVYECDVFFPEIDENVFQITSVSDVYTSNCTSLDFVIFSKRKKALT
QESLPHQSSGSDKGSNTSSTISNGAMSSNTIRGSTTSSSGKGKGGGESIFEREYNFMGDE
EDDLVYFNFNNNKNEYKNAENANDFKIYNSLKFKHHPEYQYLSIIYDIIMNGNKQNDRTG
VGVLSKFGYIMKFNLNQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEAN
GTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHANYEDKGVDQLKNIIHLIKNDP
TSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSI
FTHMIAQVCNLQPAQFIHILGNAHVYNNHIDSLKVQLNRIPYPFPTLKLNPEIKNIEDFT
ISDFTIQNYVHHDKISMDMAA
NT seq
1866 nt
NT seq
+upstream
nt +downstream
nt
atggaagacctggctgatattttcgacatatatgccatctgcgcttgctgtaaagtgcca
aatcagggtgaaggtaaaaaaaatgaaatatttagcaccaaaacgtttagaggccttggc
aataaaggatgtctaccatggaaaagtaattcgttagatatgaaatatttcagatcagta
actacatatgttaatgaaatgaaatataaaaaattaaaatataaaagagagaaatattta
gaaaaggaaatatcaaatgaaaacagtagtacagtttttgaaaatatatcactactgtca
tcaagtaaattacaaaatgttgtagtgatggggagaagtaactgggttagtattccaaag
cagtataagcctttgccgaacagaataaatgtagtactatcaagaacacttaaaaaagaa
gatgttaaagaagatatttttataataaataatatggatcaactagttttacttttaaaa
aaattaaattattacaaatgctttattattggtggggcaatagtttacaaggagtgttta
gaaagaaatttaataaaacaaatttattttacgagaataaataatgtctacgaatgtgat
gttttctttccagaaattgatgaaaatgtgtttcaaattacgtctgtgagtgatgtgtat
actagcaactgcacgtcgttagactttgtaattttcagtaaacgcaagaaggcattgacc
caagaatccctcccccatcagagtagtggaagcgacaaaggcagtaacaccagcagtact
atcagcaatggtgctatgagcagtaatactatcaggggtagtactacaagcagcagtggt
aaagggaaaggaggaggcgaatctatttttgagcgggaatataacttcatgggagacgaa
gaagacgatttagtatatttcaactttaataataacaaaaatgaatataaaaatgcagaa
aatgccaatgactttaaaatatacaacagtttaaaatttaaacatcacccagaatatcaa
tatttaagtattatatatgatatcattatgaatggaaataaacaaaatgacagaacaggt
gtaggagtactaagtaaatttgggtatattatgaaatttaatttaaatcaatattttcca
ttattaacaacaaagaaattattccttagaggaataattgaagagttactttggtttata
agaggagaaacaaatggaaatactttgttaaataaaaatgtaagaatatgggaagcaaat
ggaacaagagaatttttggataacagaaaattattccatagagaagttaatgacttagga
cctatatatggttttcaatggaggcatttcggtgctgaatatacaaatatgcatgccaac
tatgaagataaaggagttgatcaattaaaaaatattatccatttaataaaaaatgatcca
actagtagaagaattattttgtgtgcatggaatgttaaagatcttgatcaaatggcacta
cctccttgtcatattttatgccaattttatgtttttgatggaaaattatcatgtattatg
tatcaaaggtcatgtgatttaggtttaggagtcccttttaatattgcctcctattcaata
ttcactcatatgattgcacaagtgtgtaatttacagcctgcacagttcatacatatttta
ggaaatgcacatgtttataataatcatattgacagcttaaaagtacagttaaataggata
ccctaccccttcccaactcttaaattaaatcctgaaataaagaacattgaagactttaca
atatcggattttacaatccaaaattacgtgcaccatgataaaatttctatggacatggcc
gcgtga
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