Komagataella phaffii: PAS_chr1-1_0184
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Entry
PAS_chr1-1_0184 CDS
T01092
Name
(RefSeq) Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
ppa
Komagataella phaffii
Pathway
ppa00270
Cysteine and methionine metabolism
ppa00480
Glutathione metabolism
ppa01100
Metabolic pathways
ppa01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
ppa00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
PAS_chr1-1_0184
09106 Metabolism of other amino acids
00480 Glutathione metabolism
PAS_chr1-1_0184
Enzymes [BR:
ppa01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
PAS_chr1-1_0184
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Gene cluster
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Motif
Pfam:
GCS
DUF5112
Motif
Other DBs
NCBI-GeneID:
8197920
NCBI-ProteinID:
XP_002489831
UniProt:
C4QWC7
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Position
1:900834..902810
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AA seq
658 aa
AA seq
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MGLLSLGTPYSWFESRSYCDHVKKNALEQLYHCFEAAKNRSDDKYFWGDEVEYMVVHMDS
KAKKAQLSIDEDHVFADLADEKICDERDVSYHPEYGRFMIEATPYRPYDGDSLSHYLYVQ
ENMDTRRQLAQKYLKDPDAVLISLTTFPRMGTDDFTFPAAIVGGPSAKSLFVPEEITNRH
VRFPTLTANIRRRRGCKVAINIPLYKDKYTRKDDELDPTIPFNRSKFPYSDAEAGQGAAL
PGHIYMDAMGFGMGSSCLQITMQAQDLKTARYLYDSLMNIAPLALSASASAPIFRGFLAD
QDVRWNVISGAVDDRTPYERGVDPLPGHGAKGNIKEGKPVIRIPKSRYDSVDQYLSDPSD
SFNEESYNDLDSPINEEAYKTLLSYGFDSTLAHHFAHLFIRDPIVIFNERVHQDNTKEND
HFENIQSTNWQTLRFKPPTQFATPDQKDQPGWRVELRPMEISITSFENAAYSVFFTLLSK
AILLFRPNFYLPVSLIEENMVTAHRVDSIIKDKFHFRVNTESVKSDAIIKELTIKEVFHG
SSDFEGLISLVNKAIDSQSKLWSKEFSSSQEFDHALGKLKVYIKFIGLRTSGEIPSTARF
IRDFVIKHPEYKQDSVVSDSVSYDLLEKLVKLTKYERDTVAEFFGPELTHDLEAFQFI
NT seq
1977 nt
NT seq
+upstream
nt +downstream
nt
atgggattattatcgttgggcacaccttactcgtggttcgaaagcaggagctactgtgat
cacgttaagaagaacgcgttagagcaactgtatcattgtttcgaagcagcaaagaaccgg
agtgacgacaaatatttttggggagatgaagtcgagtatatggtagtacatatggattcg
aaggccaaaaaggcgcaattatccatcgatgaagatcacgtttttgctgacttagccgac
gagaagatctgcgatgagcgtgatgtttcttaccatccagagtatggtaggttcatgata
gaggcgactccttacagaccttacgatggtgacagtctgtctcattatttgtatgtccaa
gaaaacatggacactaggaggcaattggctcagaagtacttgaaagaccctgatgcagtt
ttgatttcactgacaactttcccaaggatggggacagatgatttcacctttccagctgcc
atcgtcggcggaccttccgcaaagtcgttatttgtacctgaggaaatcaccaatagacat
gttaggtttcccacgttaacagcaaatattcgtcgccgaagaggttgtaaagtggctatc
aatattcctttgtataaggacaagtataccagaaaggatgacgagttggatcctaccatc
ccgttcaacagatccaagtttccatacagtgacgcagaagctggtcaaggtgccgcatta
cctggtcatatttatatggatgctatgggttttggtatgggttcttcttgcctacaaatc
accatgcaagcgcaggacttgaagactgccagatacttgtacgattcgttgatgaatatt
gctcccttggcactctcagccagtgcttccgcacctatatttagaggattcttggctgat
caggatgtcaggtggaatgttatatctggtgccgtggatgatagaactccgtatgaaaga
ggagtcgatccattaccaggccatggtgccaagggcaacattaaggaaggtaagccagtt
attagaattccaaagtctcgatatgactccgttgaccagtaccttagtgacccttcagat
tcattcaatgaggagagttacaacgacttggattctcccataaacgaagaagcctacaaa
accttgctatcgtatgggttcgacagtaccttggctcatcattttgcccacctgtttatc
agggatcctattgtgatcttcaatgaacgagtccaccaggacaacacgaaggagaacgat
cattttgagaacatccagagcactaattggcaaaccttgagattcaagccccctactcag
tttgcaacgcctgatcaaaaggatcaaccaggttggagagtagagttaagaccaatggag
attagcatcaccagttttgaaaacgcagcctactctgtctttttcactttgttgtccaag
gctatcctactattcagacccaatttttacttacctgtctccctgatagaggagaatatg
gttactgcccatcgtgtagactctattataaaggacaaattccacttcagagtcaacaca
gagtcagtcaaaagcgacgccataatcaaggagctgaccatcaaagaagttttccatggt
tcatccgactttgaaggtttaatttccctcgttaataaggccattgattctcagtcgaag
ctgtggtcgaaagagttttcctcatctcaggaatttgatcatgctttaggaaagttgaag
gtgtatatcaagttcattggactccgtaccagtggcgaaataccctctaccgcaagattt
atccgtgactttgtaattaagcatccagaatacaagcaagatagtgttgtttcagactca
gttagttacgacctcttagagaaactggtgaaactgaccaagtatgaaagggatactgtc
gctgagttctttggtcccgaattaacgcacgatcttgaagcgttccaatttatctag
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