Pleuronectes platessa (European plaice): 128448174 Help Entry 128448174         CDS       T09923                                  Symbol obscna Name (RefSeq) LOW QUALITY PROTEIN: obscurin   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism pplt  Pleuronectes platessa (European plaice) Pathway pplt04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:pplt00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     128448174 (obscna)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pplt01001]     128448174 (obscna)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:pplt04131]     128448174 (obscna) Enzymes [BR:pplt01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      128448174 (obscna) Protein kinases [BR:pplt01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    128448174 (obscna) Membrane trafficking [BR:pplt04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     128448174 (obscna) BRITE hierarchy Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Pkinase Ig_5 PK_Tyr_Ser-Thr Ig_4 Izumo-Ig C1-set Ig_6 RhoGEF C2-set_2 IQ_SEC7_PH Kdo IQ fn3 PH RIO1 PH_19 APH Motif Other DBs NCBI-GeneID:  128448174 NCBI-ProteinID:  XP_053286709 LinkDB All DBs Position 9:complement(16062133..16100521) Genome browser AA seq 6653 aa AA seqDB search MGDNIPGGIVAAAKNRLQVVKGLEDVEVSECESCSFEVTLNLAYIEGVWSRDGMQLKSKP NCRISRHGKKHSLILNRAALGDAGLFSFQANGIQTSGQLSVRARDINIVKELEDVDTIER QPVNFMCEVNQVDVDGRWHRNDSRIRSGHNIKIRHQDKTHTLVFESVRPEHAGEIRFTAE RVSSYATLTVRELPVQIVRPLRVKIAMYHHRGLLECQVSRPNAQVRWYKNRKELVSSKKY QLISQDVYRQLTIDDICSSDEDTYTCDAGDDTTSCQLLVEEQAIRIVRGLSSVEVMEPMP ALFQAVTSLKSGRPPRWTLNGEVLESCAAVNIDRDGNLHSLCLTSTDSSMSGPVVFVAGK SRSNAQLTVTERPLQVVHHLDDAKVKENSSVTLSCQFAPSPRVVRWFKGRTALKTTNKYS MKRDGKRAELTIHGLTGMDGGQYRCLAGGSQSTAHVTVEVRTLKLVKHLEPVEIEEEGFA TFSCELNYVVANVEWLVNNVRIYSSAINRIQHMGTMHSLTVKKLQPQQSRVTFKAGLLSE TTILKVKARPAVFLRSLEDAVGEELGEVCLQCEISKETVTPVWRKDGMVLTADDKHELLQ FGRSMVLIIHSLSKDDAGHYTCDLGTSQTKAKVTVHDLHITIVHRMKTTSVLEGESCNFE CLLSHNLDDEASWTINGQVVVTNSRIQVINNGHKYEMTIRDAMLSDAGDVVFTIKDLSCR TMLFVKEKPVHIFRDLLNVKAVPGEDAELSCEITKPEVPIRWLKNGHLIRQSPKYEMSVE KNLARLVIRNTTIRDSGEYCCEAEGVATRAKLEVRELQHTFARELRDARAEEKAKVTLEC ETRQPAKRVIWLKGMVELRSGRKYVLRQKGVLLSLTISCLDKSDTDIYTCDVGTMQSRAQ LTVQGQKVLILDELEDVECLEGDTVTFRCRICPSDYIGVKWYLDETLLYTNELNEIQMVP GGYNMLTFKQLARKDTGTISFSAGDKRSYASLLVRERRPTIIKALEDCEAIEGGGLVLSC VTSKPCHILWYKDGCLMWSSSRYSASRSGCEARLTFREVCNNDAGVYECSAGSVTTRAVV TVKAIPAEFTKTLKAVEANEGETVTLTCEYSLPGVQVIWRKGFESIRHGDKYVMKQRRTI NSITIKALKPEDSGEYTCQCRDHRTTASVKVLAIPISFIQQLRNTQAEEGNNVTLRCELS KPVITFEWRKGDELLKNGIKFQIKRRETTLELLIWKTVHEDSGVYSCVCADQMTSATVKI TALPVTFKQKLRNVLIEEGNTATFRCELSKPGHTVEWRKRGEDLLRNGEKYHIRQRDMLI ELRILDVTPDDSDIYTCICGNIETTATLTVNALPITFKQKLKNLQVEEGNNITLCCEISK PGVPAEWRLGGEELENGEKYQMKQRDRALELTIREAVPEDSGVYTCVCRDQRTKATVKVI GVPATFKVSLKSQEAEEGSGVTLRCELSKKGVLLQWQRDGQVLSEEMSRGRYQMKVEGKT AMLTILSVQPGDAGKYSCIMGDEKTTAEVKVKPQPVTFKREIQRLVAKEGDSGVFCCELN KPGAPVEWRKGRAVLKPGQKYEMKQEGRLTKLVINSIEESDAGKYTCQTKDSQSTAELTV QESHERRRQRDLPPSFKMPLVNQEVTEGNSVVLHCELNKPAPSVEWTRGGEPLKNGDKYQ MRKKELQVEMKIVDLSLDDMGDYTCLCGDQSTTARILVNEQPIKFLQELKNIQVQEGNGV TLCCELSKPDTPVQWKKGDSLLTGGEKYQMKQNGPTLELLIRKSLPEDSGTYSCVCEDMK TTATIIITAIPVTFKQKLKNQEAVEEGSVMLRCELSKPGVPVEWWRDAQLLKEGDKYQMK QEGRMAEMLIRNVTLADSGEYCCSVGTVVTSADIKVRVLPVTFTQEVENLEVKEGDSGVF CCELSKLGAPVDWRKGRVVLKPGYKYEMKQQGRRTELIINNVEESDAGKYTCKTKDSQSA AELAVKAPPITFKMKLKSLQVEEESSVTLSCELSKPGLAAEWRKGEERLKNNFKYQIKSR NSIMELTIKNSQLEDSGLYSCVYGDAKTTANVTITPIPLTFKMGLKNQEASEGGNVSLHC ELSRVGVPVQWWKAEDQLSQGGRYRMMLKGNVAEMHIKNVQPEDVGQYSCVFGEQKTTAE VNVRAAASVFFEKELENKVVMEGKPVLMSCEVSNANVPVTWKRDNIVLEEGGRCILKKNG PTHSLEIRKLLLEDAGEYCCITRGKRTTAKLVVRERVRIVTGLQDVTVTAGEDAVFVCEL SHADVSEGVWWLGSSPLQSNEMNQMTCRGREHRLVLTMTTPEETGTVAFVIGEERTSACL LVVAKPKVLFEEKPQDVVIMEGETATLSCTISDFTSTVIWRRNHIPLSNSDKYDLRKQGK VNLLVICDVEPLDTGIYSCDTGDMQSSAKLSVTELPPFFQEELQSVEATEGGSASLFCEL SKLGVPIQWKKNRLPLRSSRKYEMKQDGCLLQLHIKELRLEDSGSYSCEAGSVETTAAVT VKELPPFFKKELRRVEAEEGRAASLCCELSKPGVSVQWKKSTLPLRASRKYEMEQDGCLL YLQIKELTPEDSGRYTCQAGSAETTATVTVKELPPFFIEELQNVRAEEGCSASLCCEVSK PGLSVQWKKNKLPLRAGRKYEMKQDGCLLQLQIKELNPEDSGSYTCQTGSVETTATVTVK EIQPFFNEELHNVEAEEGGTASLCCEVSKPGLSVQWKKNKLPLRANRKYEMNQDGCLLQL HIKDLKPEDSGSYTCQAGSVETTATVTVKEIQPFFNTELQNVEAEEGGTASLCCEVSKPE LSVQWKKNRLPLRANRKYDMKQDGSLLQLYIKDLKPEDSGSYTCQTGSVETSATVSVKGE CALVDXLYQDIHFNNGFLHKLYYEPTNLIGSLEKKNXGFQKCRFHXGLKLHPILQMFDAV YSCFLFPELPPSFKTDLQSMEAEEGDAVTLSCEVSKPGLLVQWKKNRLSLRASRKYKMKQ DGCLIELHIEEVKPEDSGSYTCQVGATETSATVTVKELPLFFNKELQSVEAEEGGAASLS CEVSKPEVSVQWKKNNLPLRANRKYEIEQDGCLLYLHIKELKPEDSGSYTCQTGSVETTA TVTVKELLPFFHRKLKNVEAEEGSTASLSCEVSKPEVSVQWKKNNLPLRANRKYEIKQDG CLLHLHIKELKPEDSGSYTCQTGSVETTATVTVKGVCNLAMCNKILPYQQYSQATEKXSY CNLNSVLXGIQVSGNNLRRHIWKCLRHNFNDVNTLSPSFXQCFTELTPFFKKDLQSTEAE EGGKVSLSCEVSKPGLSVQWKKNNLPLRANRKYEMKQDGCLLHLHIKDLRPDDSGSYACQ AGSVETTASVTVKELPPFFNQELLNVEAEEGGTASLSCEVSKPGLSMQWKKNKLPLRANR KYEMKQDGCFLQLHIKELKPEDSGSYTCEAESVASIASVRVKEIQPFFNTELQNVEAEEG GTASLGCEVSKPGLSVQWKKNNRPLRANRKYDMKQDGCLLQLNINDLKPEDSGWYTCEAG SVETSATVTVKELPPFFKKDLQSMEAEEGGAVSLSCEVSKHVLSVQWKKDRLQLTASRKY KMKQDGCLLELHVEALKPEDSGSYTCQAGSAETTAAVTVKELPPFFKKDLVNVEAEEGGA ASLSCEVSKPGVSVQWRKNNLPLRANRKYEMKQDGCLLCLQIKELKPEDSGSYTCQTGSV ETTANVTVKENENSGLPEAKPVPPEPKKRANRKASITNSEKDVEPLMDLKKSLGENKEDQ KGNHVVKSMENDFDSVHNTTQHEKNEEKADKSVSLLETDIRPVEEPGRSMESETEVLLEQ KQPRRNSEDAVQADLQLRQSERILGDAVVEQTKPVLMYQEREGGVGPSLKQPGKPSEVIT VVEKKSKPPGIIQWKDGEEEPVKQPEGLMGKETKQHVKSTMKEGDETEEEPLKPPVRSKA KTAERKQSSAFVVNKTEEVIPHALDTIVNDSQKDHEQRESLKQQEAGREKKPLVQVPVIR LDKASLEQQEKPSEREAEAPRPPVRIKSKAKGGTERQLSRDTETDHEGQELTGGVAKIKD DQPIRQSERPVVKEVKEKPRFERKLSVTTDTKTDEKIRQPVKASEKDENTKQTIKQPVKP IRKETGADKEIKLAVEPTRREEGPQTMKKLEDVPLLYISEDETFLEALTEIPVNHSKIHP IASVTEGSNQSSSPPPINVPQKTPPSEEASPEFDISVEDEPQLQEAAVKIQAAFKGFKAR KDMRPVFKEVFKNQSADVHSTLTLVCVVEGKPSTVRWLRKATEITNDHRCRSRTTANGDC TLVIKNLTTSDSGIYTCEVVNKFGVTSYNGNVTVVQPQQPAPEAQKTVHPPLAAITPLQL AAPTPQSPGPIPTAATDAANYVESVSVSLWEAYNLTEQDLPMGLQERRGSSLIAASSMSS PSDYDTAPDIMEPVETSPAVPREEPIAEDQVSPKVDKEEIAAPQPPKQLLKVIGAPDGKM RIQSPKHHRAHTPLASTVSGSESEGEEDSRETFEMYVARADCSPNNGNKDSFILKEGQFV EVLDSVHPDRWLVRTKPTKTSPARQGWVCPAYLEKKRRETFPQVRAPQEDLDGIGSSGEE YRRALSQLVQGLVDGEEEFVKEMKTFTSHQLNYLDTSRHIPTNILAQKEIIFRNIKDIVL LHDRSILPGLRGCATDDDVAMHLIQHTEDFEKYLHYIVGQAQAEACVADKATQQYFKELT ESSQRDAPYMDVLTFLQRPVERIQTYQALLKELIKNKAKSGQSCCLLEDAFSMVSCLPWR SDNLHQVSLIENYPAPLTALGEPVRQGVFTVWEDTPEMKTASRGHQRQVFLFKDCIVLCK LKRDTRINSVTYTFKNKMKLNDVEIKEIVVGDEKSWGLWHEHRGSVRRYKLQGRSALAKL PWLKDLKELQQRSSLPTNSPPVFESLLSDCLTKIGQTIKLTCKVTGSPKPVISWFKDGHP LEDDPRHIITADRSGTCSLILDSLTADDSGQYTCYATSSMGAAGTLAKVVVQAPPRFVSR LESACLIEGEDIQFICSTLSTPLPRIRWLKDGRELADRQKYFILNDVRSGILCLTIIRAT EADIGQYECELWNEFGCVKCKAGLCPAYVPPTDDENDQPQDLPPKDADSEGWSTAFVKKW LQTDFSPTSIAKMLFTPGNPEQAECSTEETVPATTPMDESVQQHLYLEEVEEEIYISEPM QEITDAPPSIQVPTEDLCVDPGQSATFTTIITGRPAPQIQWYKDEDELAANENVEMAQHG ARCSLTVVCPEGEDSGTYTCFAFNSSGHDSCQAQLTVEEGPLECQEREVELGKRRKLFSV YDVHEEIGRGAFGVVKRVVHRRTGEVFAAKFLPLRSSTRTRAFQERDLLSRLAHPRVACL LDFFCTRRTLVLITEICCSHGLLDHLLLRGSVSEKEVQSYIQQIFEGVGHIHSMNILHLD IKPDNILMVYPPRDEIKICDFGFCQEMDTSRHQYSLFGTPEFIAPEIVHQEPVTGATDIW AVGVMAYLCLVCRCPFVGDTDRATLLRVGEGTLNWEAPDVTSRSPEAQSFLHLLLQPDPE RRPSAFECLSHEWFQDENAGEDTEEINTKSLRVYISKTKWQRSLTCIGSVLTLRPVPELL DAPLRETAVTVPRELQEHSSTSVSSGSSSEYDEADSWDFFQHYSPTEEEEEEETEEDYDP LMERAQIPEPFPKLHLGAEEEEEMTLGEEEDGEILGRRSVLERSMSRQSVASSDASCQQT PQRERRFSKDSSPSLHLSDWDEGSGSDGGRIPRGSVIRSTFYSSSQQLSPMSARHMSLRD KFQARKQERGRKPLRRSFSGRLNEPLIEYVEDETETNRGQRRGSIQASIQKSCSFDSGVG LAHGNVPPHRRSRSLDEYSRRSPSSPPRTKPGDEEGSQSLKEDFTDDEVAGRRVLPIPSP RRPTRRRGSVAPVHGAHTLGATPAPSNFLAGNRTGNRQDREQTERGNTPSGSMGSLAESY ILEPGGSESSSRLGSYEELSHGHLRGRYRSGDSEEYDDHQEPLLSSSSCSFQEVKPRGPF PQAPPRNRTRSNPSLSPSPSPSLSSLQAPERPPRVRDKKEAQGLQRHASAPALELQQPTG KSPRLGLLKIFRRQSWTGHSYSQLDDPELGPTLGEIMKPDTPTMSLRKKMRASASSLTKL FSRSSSKEDVSKGPIVKGSSAIPAEREQGLESPKKRTSKILPSFKIPRFKKPKDLLVRPN KADVLQLDGGGVLLVWKPVKSNDPITYCVQYCTDGGDWTLLSEEVTDSSYVAKDLPRGAS YVFRVGCITRTGAGPFSEASAPVVMATHPEETQISLIQTETLGSKVTGSAQKNFSFLAEI NRGRFSVLNLCRDVETSQVFAAKITPYQAEKRQLVLREYQLLKRLHHPHLVQLHTAYITS RYLVLVEELCPGKELLYSLAGRDLYAESHVAELLVQILGAVDYLHSRRIIHLDLKSDNML VDDNRLKIVDFGSAQSFTPGQPLNIEHIEGLSESKVYIVLPKAPEILEGQGVGPETDIWA VGVLSFIMLSADSPFQEEQDKNIKKGKIQFGCCYPGLSEGALNFMKSSLNNKSWGRPTAA ECLQNPWLRAHRVPHKVRHSKVCFSTDKLKAYLTQKEEKRELVRTKLQGPFFQ NT seq 19962 nt NT seq  +upstreamnt  +downstreamnt atgggagacaacatacctggaggaatagtcgcagctgcaaagaaccggctgcaggtggtg aagggtttggaggatgtggaggtgtctgagtgtgagagctgctcctttgaggtgaccctc aacctggcctacatcgagggcgtgtggagcagggatgggatgcaactcaagtccaagccc aactgtcgcatcagcaggcacgggaagaaacattccctcatactgaacagggcggctctg ggagatgcaggcctgttctctttccaggctaatggcattcagacctcaggccaactcagt gtcagagctagggacatcaacatagtgaaggagctggaagatgttgacacaattgagcgt caacccgtgaacttcatgtgtgaggtcaatcaggtggatgtggatggtcgttggcaccga aatgacagcaggatccgatctgggcacaacatcaagatcagacaccaggataaaactcac accctggtctttgagtcagtcaggccagagcacgctggagagatcagattcactgctgag cgtgtgtcatcctatgcaactctcacagttagagagctcccggtccaaatagtgcgccct ctaagggtgaagattgcaatgtaccaccaccggggtctgctggagtgtcaggtgtcacga cccaatgctcaggtcaggtggtacaagaacaggaaggagctcgtgtccagtaagaagtac caactgatcagccaagatgtctacaggcaactgaccatcgacgacatctgctcctcggat gaagacacttacacctgtgatgccggagatgatacgacctcgtgtcagcttctggtggag gagcaggctatccgcatagtgcgggggctgagctcagtggaggtgatggagccgatgcca gcactgttccaggcggtgaccagtctgaagtctgggaggcctccacgatggaccctgaac ggtgaggtgctggagtcgtgtgcagcggtgaacatcgacagggacggcaacctccacagt ctctgcctcacctccacggacagctccatgtctggccccgtggtctttgtagcaggcaag agtcgctccaatgctcagctcactgtgacggagcgacctcttcaggttgttcaccacctg gacgatgcaaaggtgaaggagaacagctctgtgactctgagctgtcagtttgctccttct ccccgggtggtgcggtggtttaaaggtcgcactgctctgaagaccacaaacaagtacagc atgaagagagacgggaaacgagcagagctgaccatccatggcctgactgggatggacgga gggcagtatcgctgcttggctggaggttcacagagcacagcacatgttacagtagaagtg cgcacgctcaagctggtcaaacacctcgagccagtggaaattgaggaggagggttttgcc accttctcatgtgagctcaactacgtggtcgccaacgtggagtggctcgtcaacaatgtc cggatctactccagtgccatcaacaggatccagcacatgggcacaatgcatagcctcaca gtgaagaagctgcagcctcagcagagcagggtcaccttcaaagcaggccttctttctgag actacaatcttaaaggtcaaagcacgtccggcagtgttcctgaggtctctggaggatgca gtaggagaagagctgggagaggtctgtctgcagtgtgagatttccaaagagacagtgacc cctgtttggagaaaggatggtatggtcctgacggcggatgataaacatgaactgctccag ttcgggaggtccatggtactgatcatccattcactcagcaaagatgatgctggacactac acctgtgacctggggaccagccagaccaaggctaaagtcacagtacatgacttgcacatc accattgttcatcgtatgaagacaacctctgtcctggagggtgaaagctgcaactttgag tgtctcctttctcacaatctcgacgatgaggcttcctggacaatcaatggccaggtggtg gtcaccaacagccgtatccaggttatcaacaacggccacaagtatgagatgaccataaga gatgccatgctctctgatgccggagacgtggtctttacgattaaagacctcagctgtaga accatgctttttgttaaagagaaaccagtgcacatcttcagggacctgctgaacgtgaag gcggtgccaggcgaggacgctgagctgagctgtgaaatcaccaaaccagaggtccccatc cgttggctaaaaaatggtcatctgatcagacagagcccgaagtacgagatgagtgtggag aagaacttggcgcggctggtgatcaggaacaccaccatcagagactctggagagtactgc tgtgaggctgagggcgttgccacccgtgctaagctggaggttcgagaactccagcacacg tttgcgagggagttgagggacgcgcgagcagaggaaaaagccaaagtgacccttgagtgt gagaccaggcagccagccaaacgtgtgatctggttgaagggaatggtggagctgaggtct ggaaggaagtacgtcctcaggcagaagggagtgctgctgtctctgaccatctcctgtctg gacaaatcggacacggatatttacacgtgtgacgtcggcaccatgcagagccgggcacag ctgaccgtgcagggccaaaaggttttgattctggatgaactagaggacgttgagtgtctg gaaggtgacacagtcacattcagatgtcgaatctgtcccagcgactacattggggttaaa tggtacctggatgagactctgctgtacaccaatgagctcaatgagatccagatggtgccc ggaggctacaacatgctcacatttaaacagctcgcccgtaaagacaccggcactatttcc ttctcggcaggggacaaaagatcgtacgcctcactgcttgtaagagagaggcgtcccacc atcattaaagcactggaggactgtgaggctatagaaggaggtggtttggttttgtcctgc gtgacctcgaagccgtgtcacatcctgtggtacaaagatggctgcctgatgtggagctcc tccagatactctgccagtcgctcgggctgcgaggctcgactgacgtttcgggaggtgtgc aacaatgatgctggggtgtacgagtgcagtgcaggttctgttaccactagagctgttgta actgtcaaagccattcctgcagagttcaccaagaccctgaaagctgtggaggccaacgaa ggagagactgtgaccctgacctgtgagtactctctgccgggggttcaggtcatctggagg aaaggctttgagagcatcaggcatggagacaagtatgtgatgaaacagagaaggacaatc aactctataaccatcaaagccctgaagcccgaggactcgggagaatatacatgtcagtgc cgtgatcaccgcacaacggccagtgtcaaagtgctcgctattcccatttcattcatacaa caactgaggaacacgcaggcagaggagggcaacaatgtgacattgcgctgtgagctctcc aaacctgtgattacatttgagtggaggaaaggagatgagctgttgaagaacgggatcaag ttccagatcaagaggagggagaccacactggagcttctgatctggaagactgtgcacgag gacagtggggtctacagctgtgtgtgtgctgatcagatgacatcggccaccgtcaaaatc actgctctcccagtcacattcaagcagaagctgaggaacgtgctgatcgaggagggcaac accgcgacgttccgctgtgagctgtctaagcctggtcacactgtggagtggaggaagagg ggggaagatctcctcaggaacggagagaaatatcacatacggcagagagacatgctgatt gaactgaggatcctcgatgtgacgcctgacgacagcgacatctacacatgcatctgtgga aacatagagacgactgcaactctgactgtaaatgctctacccatcaccttcaagcaaaag ctgaagaacctccaagttgaggaaggcaacaacatcacgttgtgttgtgagatctctaaa cctggagtcccggcggagtggaggctcggaggagaagagctagagaacggagagaagtac cagatgaagcagagggacagagctctggagttgaccatcagagaagctgtgccagaggac agtggtgtatacacctgtgtgtgcagagatcagaggacgaaggccactgttaaagttatc ggtgttcctgccacatttaaagtcagcctgaagagccaggaggctgaagaggggagcggt gtgacgttacgctgtgagctgtccaagaagggcgtcctgctgcagtggcagagagacggt caggtgctttctgaggagatgtctcgagggaggtatcagatgaaagtggaaggaaagacg gctatgttgaccatactcagtgtccagccaggggacgcagggaaatacagctgcatcatg ggggacgagaaaaccacagctgaagtcaaagtgaaaccacaacctgtgaccttcaagcga gagatccagcgtctggtggcgaaggaaggggacagcggcgttttctgctgtgagctcaac aaacctggagctccagtggagtggaggaaaggcagagctgtcctgaagcccggacagaag tatgaaatgaagcaagagggacgtctcactaaactggttatcaacagtatagaggagagt gatgctgggaaatacacctgccagactaaagactcccagtcaactgctgagctaaccgtg caagaatcccatgagcgcaggcgtcaaagagatttaccaccaagtttcaagatgccactc gtcaaccaggaggtgacggagggcaacagtgtggttctgcactgtgagctcaacaaacct gccccgtcagtggagtggacgagaggaggtgagccgctgaagaacggagacaagtatcag atgaggaagaaggagctccaggtggagatgaagattgtggaccttagtctggacgacatg ggagattatacctgtttgtgtggtgaccagagcacaacagccaggattctggtgaatgag cagcccatcaaattccttcaagaactgaaaaatatccaggtgcaggagggtaacggggtg acactgtgctgtgagctctccaaaccggacactcctgtgcagtggaagaaaggagacagt ttgttgaccggcggagagaaataccagatgaagcagaacggccccacgctggagctgctc atcaggaaaagcctgcctgaggacagtggcacatacagctgtgtttgtgaagacatgaaa accaccgccaccatcatcatcactgcgattccggtgactttcaaacagaagctgaagaac caggaagccgtggaggagggcagcgtgatgctgcgctgtgagctgtctaaaccaggagtc ccagtggagtggtggagggatgctcagcttctgaaggagggagacaaatatcagatgaag caagagggcaggatggcggagatgctgattagaaatgtaaccctcgcagactcaggggag tactgctgctctgttggcactgtggtgacttcagctgacatcaaagtaagagtgctccct gtaacatttacacaagaggttgagaatttggaagtgaaggaaggggacagtggagttttc tgctgtgagctctccaaacttggagctccagtggactggaggaaaggccgagttgtcctc aaacctgggtacaaatatgagatgaagcagcagggacgtcgcacagaactgatcatcaac aacgtggaggagagcgatgctgggaaatacacctgcaagactaaagacagccaatcagct gctgagctcgctgtcaaagctcctcccatcacgttcaagatgaagttaaagagcttgcag gtggaggaggagagcagtgtgacattgagctgtgagttatctaaacctggcctcgctgca gagtggaggaaaggagaggagcgtctgaagaataatttcaaatatcagatcaaaagtcga aacagcatcatggagctgaccatcaaaaactcacagctggaggacagtggactctacagc tgtgtctatggcgatgccaagactacagccaatgttaccattacaccgattcccctcact tttaaaatgggtctgaagaaccaggaggcctctgaagggggcaacgtgtccctgcactgt gagctgtccagggtcggggtgcctgtgcagtggtggaaggccgaggatcagctctctcaa ggcgggcggtatcggatgatgctgaaaggaaatgtagccgagatgcacatcaaaaacgtc cagccggaggacgtgggacagtacagctgtgtctttggagagcagaagacaacggctgaa gtgaatgtgcgagcggccgcatcagtgttctttgagaaggagctggagaacaaagtggta atggaggggaaacctgtgctgatgtcttgtgaagtttccaacgctaatgtccccgtcacc tggaagagggacaacattgtgctggaggaaggagggcgatgcattctgaagaagaacggc cccacgcactctctggagatcaggaaattgcttctggaagatgctggagagtactgctgc atcaccagaggcaagaggaccactgccaagctggtcgtgagggagcgcgtgcggattgta accgggctgcaggacgtgacggtgacagcaggggaggatgcagtgtttgtgtgtgagctg agccatgctgatgtgagtgaaggtgtctggtggctcggatccagccccctgcagagcaat gagatgaaccagatgacgtgccggggtcgagagcaccgactggtcctcaccatgacaaca ccggaggaaacgggcacggtggcgtttgtgattggggaagagcggacctctgcctgtctg ctagtggtcgctaagcccaaagttttattcgaggagaagccacaagacgttgtgatcatg gaaggagagacagccaccttgtcctgcacgatctctgactttacctccactgttatctgg agacggaaccacattcccctgagcaacagtgataaatatgacttacgtaaacagggaaaa gtcaacctactggttatctgtgacgtggagcctcttgatactggcatatactcctgtgat acaggagacatgcagagcagtgccaaactcagcgttacagagctccctccattcttccag gaggaactgcagagtgtggaagcaacagagggaggttcggcctcgctgttctgtgagctg tctaaactgggagtgccgattcagtggaagaagaacaggctgccgctgagatccagcagg aagtacgagatgaagcaggacggctgcctactacagctgcacatcaaggagctcagactc gaggacagtggcagctactcatgtgaggcaggaagtgtagagaccactgcggcggtgaca gtgaaagagctgccgccattcttcaagaaagagctgagaagagtggaggctgaggaggga cgagcagcctccttgtgctgtgagctgtctaaacctggagtgtcagtgcagtggaagaag agcaccctaccacttagggccagcaggaagtacgagatggaacaagatggctgcctcctt tatcttcagatcaaggagctcacacctgaggacagtggcagatacacatgtcaagcagga agtgcagagaccactgcgactgtgacagtgaaagagctcccaccatttttcatagaggaa ctgcaaaatgtgagggcagaggagggatgttctgcctccctgtgctgtgaggtgtctaaa cctgggctgtcagtgcaatggaagaagaacaagctgccattgagagctggcaggaagtat gagatgaaacaagatggctgcctcctccagctgcagatcaaggagctcaaccctgaggac agtggcagctacacatgtcaaacaggaagtgtagagaccactgcgactgtgacagtgaaa gagatccaaccattcttcaatgaagaattacataatgtggaggcagaggagggaggtaca gcctcactgtgctgtgaggtgtccaaaccggggctgtcagtgcaatggaagaagaacaaa cttccactgagagcaaacaggaagtatgagatgaatcaagacggctgcctcctccagctg cacataaaggatctcaaacccgaggacagtggcagctacacatgtcaagcaggaagtgta gagaccactgcgactgtgacagtgaaagagatccaaccatttttcaatacagaattgcag aatgtggaggcagaggaaggaggtacagcctcactgtgctgtgaggtgtccaaacctgag ctgtcagtgcaatggaagaagaacagattgccactaagagcaaacagaaagtatgacatg aaacaagatggcagcctcctccagctatacataaaggatctcaaacctgaggacagtggc agctacacatgtcaaacaggaagtgtggagaccagtgcaactgtgtcagtgaaaggtgag tgtgcattagtggactgactgtatcaggacattcattttaacaatggtttcctacataaa ctatattatgaacccaccaacctaataggaagcctggagaaaaaaaactaaggttttcaa aaatgtcggttccactgaggtttaaagcttcatccaattttacagatgttcgatgcagtt tattcttgcttcttgtttccagaactccctccatctttcaagacagacttacagagtatg gaggctgaggagggagatgcagtcaccctgtcctgtgaagtatctaaacctggtctgcta gtgcaatggaagaagaacagactatcactgagagccagcaggaagtacaagatgaagcag gatggctgcctcattgagctccacatagaggaggtcaaacctgaggacagtggcagctac acatgtcaagtaggagctacagagacatctgcaaccgtgacagtgaaggagcttcctcta ttcttcaacaaagaattacaaagtgttgaagctgaggagggaggtgcagcttccctgtcc tgtgaggtgtctaaacctgaagtgtcagtgcagtggaagaagaacaatctgccactgaga gccaacaggaagtatgagatagaacaagatggctgcctcctctacctgcacatcaaggag ctcaaacctgaggacagtggcagctacacgtgtcaaacaggaagtgtagagaccactgcg acagtgacagtaaaagagctgctgccattcttccacaggaaattaaaaaatgtggaggca gaggagggaagtacagcctccttgtcctgtgaggtgtcgaaacctgaggtgtcagtgcaa tggaagaagaacaatctgccactgagagcaaacaggaagtatgagattaaacaagatggc tgcctccttcacctgcacatcaaggagctcaaacctgaggacagcggcagctacacatgt caaacaggaagtgtagagaccaccgcaactgttactgtcaaaggtgtgtgcaatttggca atgtgcaacaaaatattaccatatcaacaatactctcaggccacagagaagtaatcttat tgtaatttaaattctgttttgtgagggattcaagtttctgggaataatcttaggagacac atctggaaatgtcttaggcacaatttcaatgatgttaatacactgtccccctctttctga caatgtttcacagagcttaccccattcttcaagaaggacttgcagagtacggaggctgag gagggaggtaaagtctccctttcctgtgaagtgtctaaacctggtctgtcagtgcagtgg aagaagaacaatctgccactcagagcaaacaggaagtatgagatgaaacaagatggctgc ctcctccatctgcatatcaaggatctcagacctgacgacagtggcagctatgcatgtcaa gcaggaagtgtagagaccaccgcaagtgtaactgtcaaagaactccctccattcttcaat caagaattacttaatgtggaggcagaggagggaggtacagcctcactgtcctgtgaggtg tccaaacctgggctgtcaatgcaatggaagaagaacaaacttccactgagagcaaacagg aagtatgagatgaaacaagacggttgcttcctccagctgcacataaaggagctcaaaccc gaggacagtggcagctacacatgtgaagcagaaagtgtagcatccattgcgtctgtgaga gtgaaagagatccaaccatttttcaatacagaattacagaatgtggaggctgaagaggga ggtacagcctcactgggctgtgaggtgtccaaacctgggctgtcagtgcaatggaagaag aacaatcggccacttagagcaaacagaaagtatgatatgaaacaagatggctgcctcctc cagctgaacataaatgatctcaaacctgaggacagtggctggtacacctgtgaagcagga agtgtagagaccagtgcaactgtaacagttaaagaactccctccattcttcaaaaaggac ttacaaagtatggaggctgaggagggaggtgcagtatccctctcctgtgaggtatctaaa catgtgctgtcagtgcaatggaagaaggacagactgcagctaacagccagcaggaagtac aagatgaagcaggatggctgcctcctcgagctccacgttgaagcgctcaaacctgaggac agtggcagctacacatgtcaagcaggcagtgcagagacgacggcagctgtgacagtgaaa gagctgcctccattcttcaagaaagacttagtaaatgtggaggctgaggagggaggtgca gcttccttatcctgtgaggtgtcgaagcctggagtgtcggtgcaatggaggaagaacaat ctgccactgagagcaaacaggaagtatgagatgaaacaagatggctgcctcctctgtctg cagatcaaggagctcaaacctgaggacagtggcagctacacatgtcaaacaggaagtgtg gagaccactgcaaatgtgacagtgaaagagaatgagaattctggtctcccagaggccaaa cctgttcctcctgagcccaaaaagagagctaacaggaaagcatctattacaaattcagaa aaagatgttgagccattgatggatctgaaaaagtctctgggggagaataaagaagaccaa aagggaaaccacgttgtgaaatctatggagaacgattttgatagtgtgcacaatacaaca caacatgagaagaatgaggagaaagcggataagtctgtgagtttactggagacggatatc cggccggtcgaagagccaggaagatctatggaatcagaaacggaagtgttgcttgaacag aaacaacccagaaggaattcagaggacgcagttcaagccgatcttcaattacgtcagtca gagaggattctgggtgacgctgtggttgaacagacaaagccggtattaatgtatcaggaa agggaaggtggtgttgggccgagcttaaaacaaccaggaaagccttcagaggtaataact gtggttgagaagaagtcgaaacctccaggaataatccagtggaaagacggtgaggaagag cctgtgaagcagccagaagggttaatggggaaagaaacaaagcaacatgtgaagtctaca atgaaggaaggtgacgagacagaagaggaacctttaaaaccaccagtcagatctaaagca aagacagcagagagaaaacaatcatctgcgtttgttgtgaataaaactgaggaggtaatt ccccatgcattagacacaattgtaaacgattcacagaaagaccacgaacagagagagagt ttaaaacaacaagaggcaggaagagaaaaaaagccactggtgcaggttcctgtaattcgc ttggacaaagcttcattagaacaacaggaaaaaccttcagaaagagaggctgaggctcca agaccacctgtgaggataaaaagtaaagcaaagggaggaacagagagacaactatcaagg gacacagagacagatcacgaaggacaagagctaacaggaggtgtagcgaaaataaaggat gatcagccaataaggcagtcagaaagacctgtggttaaagaggtcaaagagaagcccaga tttgagaggaaactgtcagtaacaacagacactaagacggacgagaaaatcaggcagccc gtgaaagcttcagagaaagacgaaaacaccaaacagacgataaaacaaccggtgaaaccc attagaaaggaaactggagctgacaaggaaattaaattggcagtcgagcccacgagaagg gaggaagggccacagacgatgaagaagctggaggatgttccccttctctacatttctgag gatgaaactttcttagaggctttgaccgagataccggtgaaccacagcaagatccatccc attgcttctgttactgagggatcaaaccaatcctctagtcctcctccgattaatgtcccc cagaagacgccaccatccgaggaggcttcaccagagttcgacatcagcgtggaggatgag ccacaattgcaagaggctgcagttaagatccaggctgcatttaaaggattcaaagcccgc aaagatatgcgacctgtctttaaagaggtgttcaagaaccagagtgcagatgttcatagc acactcactctagtgtgtgttgtggaagggaaacccagcacagtgcgctggctgagaaaa gctacagaaatcactaatgaccaccgctgccgttctagaaccacagcaaatggcgactgc acgctggtgatcaagaacctgaccacgagtgacagtggaatctatacgtgtgaggtggtg aataagtttggtgtaacctcctacaatggaaacgtcacagtagtgcagcctcagcaacct gctcctgaagcccagaagactgtacacccaccgcttgcagcgataactcctctgcaactt gcagcaccgacgccccagagtccaggaccgattccaactgcagctacagatgctgcgaac tatgtagaaagtgtgagcgtctctctgtgggaggcctacaacctgacggagcaggattta ccaatgggtctgcaagaaaggagaggatcatctcttattgctgccagctccatgtcgagt ccgtctgattatgacacagctcctgatataatggaacctgttgagactagtcctgctgtt ccaagggaagaaccaattgcagaagaccaagtatctccaaaggttgataaagaagagata gctgctccacaacctcctaagcaactgctgaaggtcataggggctcctgatggcaaaatg aggatacaatctccaaagcaccatcgtgcccacacacccttagctagtaccgtctctgga tcagaatcagaaggtgaagaggacagcagagagacgtttgaaatgtatgtggctcgagcg gactgcagtcctaacaatgggaataaggacagttttattctgaaggagggtcagtttgtg gaggtgctggactctgttcaccctgacaggtggctggtgaggaccaagcccaccaaaact agccccgctcgacaaggatgggtgtgtccagcctatctggagaagaagagaagggagact ttcccacaagttagagcacctcaagaggatcttgatggaatagggtcttcaggagaagag tacaggagagctctgagtcaattggtccaaggcctggttgatggagaggaggagtttgtg aaggagatgaagacattcacctctcaccagctgaattatctggacactagtcgccacatc cccactaacatcctcgcacagaaagagataattttcagaaatatcaaggacattgtgttg ctgcatgacagatccatcctgcctggcctaagaggctgtgccacagatgatgatgtggcc atgcatctgatccagcacactgaagactttgagaagtatcttcactacatagtgggacaa gcacaagcagaagcctgcgtcgctgacaaggctacccagcagtatttcaaggagttaaca gagtctagtcagcgtgatgctccctacatggatgttctcaccttcctccagagaccagtg gagaggattcaaacctaccaggctttactgaaggagttgataaagaacaaagccaaaagt ggtcagagctgctgtctgctggaggatgccttctccatggtgtcctgtctgccctggagg tctgacaacctgcaccaggtgtccctcatcgagaactaccctgctcctctaactgccctg ggtgaacctgtgcgacagggagtcttcacagtgtgggaggatactccagaaatgaagacg gcctctagagggcatcagagacaagtctttctcttcaaggactgcattgtgctgtgtaaa ctgaaaagagacacgcgcattaacagtgtcacctacaccttcaagaacaaaatgaagctg aatgacgtggaaataaaggagattgtggtcggggatgaaaagtcctggggtttatggcac gagcacaggggctcagtgcgccggtataagctgcagggccgctccgcactggctaaactc ccctggctcaaggacctgaaggagctccagcagcgctccagtctgcccaccaacagtcca ccagtgttcgagtccctgttgtctgactgcttaacaaagataggacagactattaaactg acatgcaaggtcacaggatcgcccaaaccagtgatcagctggttcaaagatggccatcct ctggaggacgacccccgtcatattatcacagccgaccgctctggcacctgcagtctcatc ctggacagcctcactgcagacgactccggacagtatacgtgctacgctaccagctccatg ggcgctgctggtactctggctaaggttgtggtgcaggctccacccagatttgtgagtcgg ctggagagtgcgtgtctgatagaaggagaggatatccagttcatttgttccacgctcagc actccgttacccagaatcaggtggttgaaggacggcagagagttggctgaccggcaaaaa tattttatcctgaatgatgttcggagtggaatattgtgtctgacaatcatcagggcaaca gaggcggatattggacagtacgagtgtgagctctggaacgagtttggctgcgtcaagtgt aaagctggcctgtgcccggcttatgtgccaccgactgacgatgagaacgaccaacctcag gacttacctcctaaagatgcagactcagagggctggtccacggcctttgtgaagaagtgg ttacagactgattttagccccacttctatcgccaagatgcttttcactcctggaaaccct gaacaagcagagtgcagcactgaagagactgttcccgccaccacacccatggatgagtcg gttcagcagcatctctacctggaggaagtggaggaggagatttacatctctgaacccatg caagaaattacagatgctcctccctccatccaggtgcccactgaagacctgtgtgtagat cctggtcaatcagctacgtttactaccatcatcacagggaggcctgcccctcagatccag tggtacaaggatgaagacgagcttgcagccaatgagaatgtggagatggcacagcatggg gcccgctgctcactgaccgtagtgtgccccgagggcgaagacagcggcacatacacctgc ttcgccttcaacagctctggtcatgactcgtgccaggctcagctcacagtggaggaaggt ccactggagtgtcaggagagagaggtggagctggggaagagaaggaagttgttctctgtc tacgatgttcatgaggaaattggaaggggagcgtttggagtggtgaagcgtgtggtccac agaagaacaggtgaggtctttgctgccaagttcctgcctctgcggagcagcacacggacg agggccttccaggagcgagacctgctctcccgtctggctcatccccgagtggcctgtctg ctggacttcttctgcaccagacgcactctggtgctgatcacagaaatctgctgttctcat ggacttctggaccatttattactgagaggatcagtctcagagaaagaggttcagtcgtac atccagcaaatctttgaaggtgttggccacattcacagcatgaacatcttgcatctggac attaaacctgataatatcctcatggtatatccacccagagacgagattaagatctgtgac ttcggcttttgccaagaaatggacacatccagacaccagtacagcctgtttggaacacct gagttcattgcacctgagatcgttcaccaagagccagtcactggggccactgatatttgg gctgtgggggtcatggcttatctctgtctggtgtgtcgctgcccgtttgtgggtgacaca gaccgtgcgacactgctgagagtgggggaggggaccctgaactgggaagcgcctgatgtc accagcaggagcccagaggcccaaagctttctccacctgctccttcaaccagatccagag aggcgaccgtctgcctttgaatgcttgagccatgaatggtttcaggatgaaaatgctgga gaagacactgaggaaattaacacaaagagtttgagagtatatatctcaaaaacaaaatgg cagcggtctttgacttgcatcgggtcagtcctcacgttgaggcccgtgcccgagctgctg gacgctcctctcagagagacggcggtgactgtgcctcgcgagctgcaggaacacagcagc acctcggtcagcagtggctcctcctccgaatacgatgaagctgactcctgggactttttc cagcactacagcccgaccgaggaggaggaagaggaggagacagaggaggattatgatcct ttaatggagagagcacagatcccagagcctttccccaaactccacctaggtgcggaggaa gaggaagagatgacattaggggaggaagaagatggggagatactaggaaggaggagtgtg ttagagaggagtatgagcaggcagtcggtggcctcatcggatgcatcttgccaacagaca cctcagagggagcgtaggttcagcaaggacagcagtccatctctccacctatctgactgg gatgagggctcgggaagtgatggaggtcgtatccctcggggcagcgtgatccgaagtact ttctacagcagctctcagcagctttcacccatgtctgctagacacatgtcattacgggac aaattccaggccagaaaacaggagagaggccgcaaaccactcaggaggagcttttcagga cgcctcaatgagcctctgattgaatacgtggaggatgagacagaaactaaccgtggtcag agacggggatccatccaagcctcgatacagaaatcctgctctttcgacagcggagttggt ctcgcccacggcaacgtgccccctcacaggaggagcaggtccctggatgagtattcacgt cgctcccccagctcccccccgcgcacaaagccgggtgacgaagaaggctctcaaagtctg aaggaagattttacagatgatgaagtggcagggaggagggtgttgcccattccgagtcca cggcgccccacaagaagaagaggctccgtcgctcctgtacatggagctcacacactgggt gcaacacctgctccttcaaacttccttgctggaaacaggacgggcaacagacaggatagg gagcagacagagagaggaaacacccctagtggctccatgggttcattggctgaatcatat attttggagcccggtggttcagagtcttcgagcagactcggctcctatgaggagctgagt catggccatctcagaggaagatacagatcaggagacagtgaagagtatgatgatcaccag gagcccctgctttcatcatcctcctgctcattccaagaagtcaaacccagaggcccgttt ccacaggcaccgccgcgtaaccgcacccgctccaaccccagcttatcgccgagccccagt cccagcctctcctccctccaggctccagagaggcctcccagagtcagggacaagaaggaa gctcaaggcctccagaggcatgcatcagctccagccctggaactccagcagcccacagga aagtcacccaggctgggactgctgaagatcttccgcaggcagtcgtggactggtcactct tactctcaactggacgacccggagttaggacccacgttaggagagatcatgaagcctgat acacccaccatgtctctgaggaagaaaatgagagcttcagcctccagcctgaccaagctg ttctccagatcctccagtaaagaggatgtgagtaaagggccaatagtaaaaggatcatct gccatcccagccgaaagggaacagggtctagagagtccaaagaagaggacatccaaaatc ctgccttctttcaaaatacccagattcaaaaagccaaaagatctgctggtccgtcccaac aaagctgacgtgctccagttagatggaggcggagtcctgctggtttggaaacctgtcaag tcaaatgaccccatcacgtactgtgtgcagtactgtacagatggtggggactggacgctc ctgtcagaggaggtgacagacagcagctatgtggcgaaggatttaccgagaggagcctcg tacgtgttcagggtcggctgcatcaccaggacgggggctggacctttcagtgaagcatca gctcctgtcgtaatggcgactcaccctgaagagactcaaatctctctcattcaaactgag accctggggtcaaaggtcactggatcagcacaaaagaacttcagcttccttgctgagatc aacaggggtcggttcagcgtactgaacctttgcagggatgttgagaccagccaagtgttt gctgcaaagatcaccccctaccaggcagagaagaggcagctggtgctgagagagtaccag ctgctgaagaggcttcaccacccacatctggtgcagctgcacaccgcctacatcacctcc cgctacctggtgttggtggaggagctttgtcctggcaaggagctgctctacagtctggct ggcagagacctgtatgcagagtctcacgttgcggagctgctggttcagattctcggtgcc gtcgactaccttcacagccgtcgaatcatccacctggacctgaagtcggacaacatgctg gtggatgacaaccgcttgaagattgttgactttggctcggctcagtccttcacgcccgga cagcccctcaacatagagcacatcgaaggcctgtcggagagcaaagtttatattgtcctt cctaaagctccggaaatcctggagggtcagggcgtcgggcctgaaaccgatatctgggcc gttggggttctgtcattcatcatgttgagtgccgacagtccgttccaggaggagcaagac aaaaatatcaagaaggggaagatccagtttggatgctgttaccctggtctgtcagaggga gccttaaacttcatgaagagcagcctgaataacaaatcatgggggagacccactgcagcc gagtgcctccagaacccgtggctccgggctcatcgtgttcctcacaaagtgcgacactcc aaggtgtgtttctccaccgacaaactcaaagcgtacctcacacagaaggaggagaaacga gagctggtccgcaccaagctgcagggtcccttcttccagtaa

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