KEGG   Phocoena sinus (vaquita): 116761625
Entry
116761625         CDS       T07759                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
psiu  Phocoena sinus (vaquita)
Pathway
psiu01521  EGFR tyrosine kinase inhibitor resistance
psiu01522  Endocrine resistance
psiu04010  MAPK signaling pathway
psiu04012  ErbB signaling pathway
psiu04014  Ras signaling pathway
psiu04015  Rap1 signaling pathway
psiu04022  cGMP-PKG signaling pathway
psiu04024  cAMP signaling pathway
psiu04062  Chemokine signaling pathway
psiu04068  FoxO signaling pathway
psiu04071  Sphingolipid signaling pathway
psiu04072  Phospholipase D signaling pathway
psiu04140  Autophagy - animal
psiu04150  mTOR signaling pathway
psiu04151  PI3K-Akt signaling pathway
psiu04210  Apoptosis
psiu04218  Cellular senescence
psiu04270  Vascular smooth muscle contraction
psiu04360  Axon guidance
psiu04370  VEGF signaling pathway
psiu04371  Apelin signaling pathway
psiu04510  Focal adhesion
psiu04540  Gap junction
psiu04550  Signaling pathways regulating pluripotency of stem cells
psiu04613  Neutrophil extracellular trap formation
psiu04625  C-type lectin receptor signaling pathway
psiu04630  JAK-STAT signaling pathway
psiu04650  Natural killer cell mediated cytotoxicity
psiu04660  T cell receptor signaling pathway
psiu04662  B cell receptor signaling pathway
psiu04664  Fc epsilon RI signaling pathway
psiu04666  Fc gamma R-mediated phagocytosis
psiu04720  Long-term potentiation
psiu04722  Neurotrophin signaling pathway
psiu04726  Serotonergic synapse
psiu04730  Long-term depression
psiu04810  Regulation of actin cytoskeleton
psiu04910  Insulin signaling pathway
psiu04912  GnRH signaling pathway
psiu04914  Progesterone-mediated oocyte maturation
psiu04915  Estrogen signaling pathway
psiu04916  Melanogenesis
psiu04917  Prolactin signaling pathway
psiu04919  Thyroid hormone signaling pathway
psiu04921  Oxytocin signaling pathway
psiu04926  Relaxin signaling pathway
psiu04928  Parathyroid hormone synthesis, secretion and action
psiu04929  GnRH secretion
psiu04935  Growth hormone synthesis, secretion and action
psiu05010  Alzheimer disease
psiu05022  Pathways of neurodegeneration - multiple diseases
psiu05034  Alcoholism
psiu05132  Salmonella infection
psiu05152  Tuberculosis
psiu05160  Hepatitis C
psiu05161  Hepatitis B
psiu05163  Human cytomegalovirus infection
psiu05164  Influenza A
psiu05165  Human papillomavirus infection
psiu05167  Kaposi sarcoma-associated herpesvirus infection
psiu05170  Human immunodeficiency virus 1 infection
psiu05200  Pathways in cancer
psiu05205  Proteoglycans in cancer
psiu05206  MicroRNAs in cancer
psiu05207  Chemical carcinogenesis - receptor activation
psiu05208  Chemical carcinogenesis - reactive oxygen species
psiu05210  Colorectal cancer
psiu05211  Renal cell carcinoma
psiu05212  Pancreatic cancer
psiu05213  Endometrial cancer
psiu05214  Glioma
psiu05215  Prostate cancer
psiu05218  Melanoma
psiu05219  Bladder cancer
psiu05220  Chronic myeloid leukemia
psiu05221  Acute myeloid leukemia
psiu05223  Non-small cell lung cancer
psiu05224  Breast cancer
psiu05225  Hepatocellular carcinoma
psiu05226  Gastric cancer
psiu05230  Central carbon metabolism in cancer
psiu05231  Choline metabolism in cancer
psiu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:psiu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    116761625 (RAF1)
   04012 ErbB signaling pathway
    116761625 (RAF1)
   04014 Ras signaling pathway
    116761625 (RAF1)
   04015 Rap1 signaling pathway
    116761625 (RAF1)
   04370 VEGF signaling pathway
    116761625 (RAF1)
   04371 Apelin signaling pathway
    116761625 (RAF1)
   04630 JAK-STAT signaling pathway
    116761625 (RAF1)
   04068 FoxO signaling pathway
    116761625 (RAF1)
   04072 Phospholipase D signaling pathway
    116761625 (RAF1)
   04071 Sphingolipid signaling pathway
    116761625 (RAF1)
   04024 cAMP signaling pathway
    116761625 (RAF1)
   04022 cGMP-PKG signaling pathway
    116761625 (RAF1)
   04151 PI3K-Akt signaling pathway
    116761625 (RAF1)
   04150 mTOR signaling pathway
    116761625 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    116761625 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    116761625 (RAF1)
   04218 Cellular senescence
    116761625 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    116761625 (RAF1)
   04540 Gap junction
    116761625 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    116761625 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    116761625 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    116761625 (RAF1)
   04625 C-type lectin receptor signaling pathway
    116761625 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    116761625 (RAF1)
   04660 T cell receptor signaling pathway
    116761625 (RAF1)
   04662 B cell receptor signaling pathway
    116761625 (RAF1)
   04664 Fc epsilon RI signaling pathway
    116761625 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    116761625 (RAF1)
   04062 Chemokine signaling pathway
    116761625 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    116761625 (RAF1)
   04929 GnRH secretion
    116761625 (RAF1)
   04912 GnRH signaling pathway
    116761625 (RAF1)
   04915 Estrogen signaling pathway
    116761625 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    116761625 (RAF1)
   04917 Prolactin signaling pathway
    116761625 (RAF1)
   04921 Oxytocin signaling pathway
    116761625 (RAF1)
   04926 Relaxin signaling pathway
    116761625 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    116761625 (RAF1)
   04919 Thyroid hormone signaling pathway
    116761625 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    116761625 (RAF1)
   04916 Melanogenesis
    116761625 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    116761625 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    116761625 (RAF1)
   04720 Long-term potentiation
    116761625 (RAF1)
   04730 Long-term depression
    116761625 (RAF1)
   04722 Neurotrophin signaling pathway
    116761625 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    116761625 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116761625 (RAF1)
   05206 MicroRNAs in cancer
    116761625 (RAF1)
   05205 Proteoglycans in cancer
    116761625 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    116761625 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    116761625 (RAF1)
   05230 Central carbon metabolism in cancer
    116761625 (RAF1)
   05231 Choline metabolism in cancer
    116761625 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    116761625 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    116761625 (RAF1)
   05212 Pancreatic cancer
    116761625 (RAF1)
   05225 Hepatocellular carcinoma
    116761625 (RAF1)
   05226 Gastric cancer
    116761625 (RAF1)
   05214 Glioma
    116761625 (RAF1)
   05221 Acute myeloid leukemia
    116761625 (RAF1)
   05220 Chronic myeloid leukemia
    116761625 (RAF1)
   05218 Melanoma
    116761625 (RAF1)
   05211 Renal cell carcinoma
    116761625 (RAF1)
   05219 Bladder cancer
    116761625 (RAF1)
   05215 Prostate cancer
    116761625 (RAF1)
   05213 Endometrial cancer
    116761625 (RAF1)
   05224 Breast cancer
    116761625 (RAF1)
   05223 Non-small cell lung cancer
    116761625 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    116761625 (RAF1)
   05161 Hepatitis B
    116761625 (RAF1)
   05160 Hepatitis C
    116761625 (RAF1)
   05164 Influenza A
    116761625 (RAF1)
   05163 Human cytomegalovirus infection
    116761625 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    116761625 (RAF1)
   05165 Human papillomavirus infection
    116761625 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    116761625 (RAF1)
   05152 Tuberculosis
    116761625 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    116761625 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    116761625 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    116761625 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    116761625 (RAF1)
   01522 Endocrine resistance
    116761625 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:psiu01001]
    116761625 (RAF1)
Enzymes [BR:psiu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     116761625 (RAF1)
Protein kinases [BR:psiu01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   116761625 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 116761625
NCBI-ProteinID: XP_032503489
Ensembl: ENSPSNG00000010184
LinkDB
Position
11:4590553..4664213
AA seq 668 aa
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLQDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSIVGDSGFPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRRFCLRGRDA
IRSHGESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSSTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHISNRDQIIFMVGRGYASPDLSKLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcctggaagacgatcagcaatggttttggattcaaagacgct
gtgtttgatggccccagctgcatctcccctacaatagttcagcagtttggctatcagcgt
cgggcatcagatgatggcaaacttacggacccttctaagacaagcaacactatccgtgtt
tttttgccaaacaagcaaagaacagtggtcaatgtgcggaatggaatgagcttgcaagac
tgccttatgaaagctctcaaggtgaggggcctgcaaccagagtgctgtgcagttttcaga
cttctccacgaacacaagggtaaaaaagcacgtttagattggaatactgatgctgcctcg
ttgattggagaggaacttcaagtagatttcctggatcatgttccactcacaacacacaac
tttgctcggaagaccttcctgaaacttgccttctgtgacatctgtcagaagttcctgcta
aatgggtttagatgtcagacttgtggctacaagtttcacgagcattgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttgctgttcccaaattccatt
gttggtgatagtgggttcccagcactgccttctttgacaatgcgtcggatgcgagagtct
gtctcccggatgcctgttagttcccagcacagatactccacaccccacgctttcacattc
aacacctccagcccctcctctgaaggttccctctctcagaggcaaaggtcgacgtccaca
cctaatgtccacatggtcagcaccaccttgcccgtggacagcaggatgattgagaataac
agcctgaatgcttctcccagggcgtggtccagacgattttgtttgaggggaagagatgca
attcgaagtcacggtgaatcagcttcaccttcagccttgtccagcagtcccaacaatctg
agcccaacaggctggtcacagcccaaaacccctgtgccggcacagagagagcgggcaccg
ggatccagcacccaggagaaaaataaaattaggcctcgtggacagagagattcaagctat
tactgggagatagaagccagtgaagtgatgctctccactcggattgggtcaggctccttt
gggactgtttataagggcaagtggcatggagacgttgcagtaaagattctaaaggttgtt
gaccccacaccagagcagttccaggccttcaggaatgaagtggctgtccttcgcaaaacc
cggcacgtgaacatcctgctcttcatggggtacatgacgaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctataaacacctgcacgtccaggagaccaagttc
cagatgttccagttgattgacattgcccggcagacggctcagggaatggactacttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagactttggtttggcaacagtgaagtcgcgctggagtggttctcag
caggttgaacaacccaccggctccatcttgtggatggccccagaggtgattcgaatgcag
gacaataacccgttcagcttccagtctgacgtctactcttacggcatcgtgctgtacgag
cttatgacgggggagctgccctactcccacatcagcaaccgcgatcagatcatcttcatg
gtaggccgagggtacgcctccccagaccttagtaagctgtacaagaactgccccaaagca
atgaagaggctggtagccgactgtgtgaagaaagttaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaaaatcaaccggagcgct
tctgagccatccctgcaccgggcggcccataccgaggacatcaatgcctgcacgctgacc
acatcccctagattgcctgtcttctag

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