KEGG   Pan troglodytes (chimpanzee): 740018
Entry
740018            CDS       T01005                                 
Symbol
TYMS
Name
(RefSeq) thymidylate synthase
  KO
K00560  thymidylate synthase [EC:2.1.1.45]
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
ptr00240  Pyrimidine metabolism
ptr00670  One carbon pool by folate
ptr01100  Metabolic pathways
ptr01232  Nucleotide metabolism
ptr01523  Antifolate resistance
ptr04981  Folate transport and metabolism
Module
ptr_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:ptr00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    740018 (TYMS)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    740018 (TYMS)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    740018 (TYMS)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    740018 (TYMS)
Enzymes [BR:ptr01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     740018 (TYMS)
SSDB
Motif
Pfam: Thymidylat_synt
Other DBs
NCBI-GeneID: 740018
NCBI-ProteinID: NP_001233511
Ensembl: ENSPTRG00000009822
VGNC: 5220
UniProt: G2HEY4 A0A6D2WK22
LinkDB
Position
17:complement(30249244..30264385)
AA seq 313 aa
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIEHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKSNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
NT seq 942 nt   +upstreamnt  +downstreamnt
atgcctgtggccggctcggagctgccgcgccggcccttgccgcccgccgcacaggagcgg
gacgccgagccgcgtccgccgcacggggagctgcagtacctggggcagatcgaacacatc
ctccgctgcggcgtcaggaaggacgaccgcacgggcaccggcaccctgtcggtattcggc
atgcaggcgcgctacagcctgagagatgaatttcctctgctgacaaccaaacgtgtgttc
tggaagggtgttttggaggagttgctgtggtttatcaagggatccacaaatgctaaagag
ctgtcttccaagggagtgaaaatctgggatgccaatggatcccgagactttttggacagc
ctgggattctccaccagagaagaaggggacttgggcccagtttatggcttccagtggagg
cattttggggcagaatacagagatatggaatcagattattcaggacagggagttgaccag
ctgcaaagagtgattgacaccatcaaatccaaccctgacgacagaagaatcatcatgtgc
gcttggaatccaagagatcttcctctgatggcgctgcctccatgccatgccctctgccag
ttctatgtggtgaacagtgagctgtcctgccagctgtaccagagatcgggagacatgggc
ctcggtgtgcctttcaacatcgccagctacgccctgctcacgtacatgattgcgcacatc
acgggcctgaagccaggtgactttatacacactttgggagatgcacatatttacctgaat
cacatcgagccactgaaaattcagcttcagcgagaacccagacctttcccaaagctcaag
attcttcgaaaagttgagaaaattgatgacttcaaagctgaagactttcagattgaaggg
tacaatccacatccaactattaaaatggaaatggctgtttag

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