Panthera uncia (snow leopard): 125910082
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Entry
125910082 CDS
T08832
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
puc
Panthera uncia (snow leopard)
Pathway
puc01521
EGFR tyrosine kinase inhibitor resistance
puc01522
Endocrine resistance
puc04010
MAPK signaling pathway
puc04012
ErbB signaling pathway
puc04014
Ras signaling pathway
puc04015
Rap1 signaling pathway
puc04022
cGMP-PKG signaling pathway
puc04024
cAMP signaling pathway
puc04062
Chemokine signaling pathway
puc04066
HIF-1 signaling pathway
puc04068
FoxO signaling pathway
puc04071
Sphingolipid signaling pathway
puc04072
Phospholipase D signaling pathway
puc04114
Oocyte meiosis
puc04140
Autophagy - animal
puc04148
Efferocytosis
puc04150
mTOR signaling pathway
puc04151
PI3K-Akt signaling pathway
puc04210
Apoptosis
puc04218
Cellular senescence
puc04270
Vascular smooth muscle contraction
puc04370
VEGF signaling pathway
puc04371
Apelin signaling pathway
puc04380
Osteoclast differentiation
puc04510
Focal adhesion
puc04540
Gap junction
puc04550
Signaling pathways regulating pluripotency of stem cells
puc04613
Neutrophil extracellular trap formation
puc04620
Toll-like receptor signaling pathway
puc04650
Natural killer cell mediated cytotoxicity
puc04660
T cell receptor signaling pathway
puc04662
B cell receptor signaling pathway
puc04664
Fc epsilon RI signaling pathway
puc04666
Fc gamma R-mediated phagocytosis
puc04668
TNF signaling pathway
puc04720
Long-term potentiation
puc04722
Neurotrophin signaling pathway
puc04725
Cholinergic synapse
puc04726
Serotonergic synapse
puc04730
Long-term depression
puc04810
Regulation of actin cytoskeleton
puc04910
Insulin signaling pathway
puc04912
GnRH signaling pathway
puc04914
Progesterone-mediated oocyte maturation
puc04915
Estrogen signaling pathway
puc04916
Melanogenesis
puc04917
Prolactin signaling pathway
puc04919
Thyroid hormone signaling pathway
puc04921
Oxytocin signaling pathway
puc04926
Relaxin signaling pathway
puc04928
Parathyroid hormone synthesis, secretion and action
puc04929
GnRH secretion
puc04934
Cushing syndrome
puc04935
Growth hormone synthesis, secretion and action
puc05010
Alzheimer disease
puc05022
Pathways of neurodegeneration - multiple diseases
puc05034
Alcoholism
puc05132
Salmonella infection
puc05135
Yersinia infection
puc05160
Hepatitis C
puc05161
Hepatitis B
puc05163
Human cytomegalovirus infection
puc05164
Influenza A
puc05165
Human papillomavirus infection
puc05166
Human T-cell leukemia virus 1 infection
puc05167
Kaposi sarcoma-associated herpesvirus infection
puc05170
Human immunodeficiency virus 1 infection
puc05200
Pathways in cancer
puc05205
Proteoglycans in cancer
puc05206
MicroRNAs in cancer
puc05207
Chemical carcinogenesis - receptor activation
puc05208
Chemical carcinogenesis - reactive oxygen species
puc05210
Colorectal cancer
puc05211
Renal cell carcinoma
puc05212
Pancreatic cancer
puc05213
Endometrial cancer
puc05214
Glioma
puc05215
Prostate cancer
puc05216
Thyroid cancer
puc05218
Melanoma
puc05219
Bladder cancer
puc05220
Chronic myeloid leukemia
puc05221
Acute myeloid leukemia
puc05223
Non-small cell lung cancer
puc05224
Breast cancer
puc05225
Hepatocellular carcinoma
puc05226
Gastric cancer
puc05230
Central carbon metabolism in cancer
puc05231
Choline metabolism in cancer
puc05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
puc00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
125910082
04012 ErbB signaling pathway
125910082
04014 Ras signaling pathway
125910082
04015 Rap1 signaling pathway
125910082
04370 VEGF signaling pathway
125910082
04371 Apelin signaling pathway
125910082
04668 TNF signaling pathway
125910082
04066 HIF-1 signaling pathway
125910082
04068 FoxO signaling pathway
125910082
04072 Phospholipase D signaling pathway
125910082
04071 Sphingolipid signaling pathway
125910082
04024 cAMP signaling pathway
125910082
04022 cGMP-PKG signaling pathway
125910082
04151 PI3K-Akt signaling pathway
125910082
04150 mTOR signaling pathway
125910082
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
125910082
04148 Efferocytosis
125910082
09143 Cell growth and death
04114 Oocyte meiosis
125910082
04210 Apoptosis
125910082
04218 Cellular senescence
125910082
09144 Cellular community - eukaryotes
04510 Focal adhesion
125910082
04540 Gap junction
125910082
04550 Signaling pathways regulating pluripotency of stem cells
125910082
09142 Cell motility
04810 Regulation of actin cytoskeleton
125910082
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
125910082
04620 Toll-like receptor signaling pathway
125910082
04650 Natural killer cell mediated cytotoxicity
125910082
04660 T cell receptor signaling pathway
125910082
04662 B cell receptor signaling pathway
125910082
04664 Fc epsilon RI signaling pathway
125910082
04666 Fc gamma R-mediated phagocytosis
125910082
04062 Chemokine signaling pathway
125910082
09152 Endocrine system
04910 Insulin signaling pathway
125910082
04929 GnRH secretion
125910082
04912 GnRH signaling pathway
125910082
04915 Estrogen signaling pathway
125910082
04914 Progesterone-mediated oocyte maturation
125910082
04917 Prolactin signaling pathway
125910082
04921 Oxytocin signaling pathway
125910082
04926 Relaxin signaling pathway
125910082
04935 Growth hormone synthesis, secretion and action
125910082
04919 Thyroid hormone signaling pathway
125910082
04928 Parathyroid hormone synthesis, secretion and action
125910082
04916 Melanogenesis
125910082
09153 Circulatory system
04270 Vascular smooth muscle contraction
125910082
09156 Nervous system
04725 Cholinergic synapse
125910082
04726 Serotonergic synapse
125910082
04720 Long-term potentiation
125910082
04730 Long-term depression
125910082
04722 Neurotrophin signaling pathway
125910082
09158 Development and regeneration
04380 Osteoclast differentiation
125910082
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
125910082
05206 MicroRNAs in cancer
125910082
05205 Proteoglycans in cancer
125910082
05207 Chemical carcinogenesis - receptor activation
125910082
05208 Chemical carcinogenesis - reactive oxygen species
125910082
05230 Central carbon metabolism in cancer
125910082
05231 Choline metabolism in cancer
125910082
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
125910082
09162 Cancer: specific types
05210 Colorectal cancer
125910082
05212 Pancreatic cancer
125910082
05225 Hepatocellular carcinoma
125910082
05226 Gastric cancer
125910082
05214 Glioma
125910082
05216 Thyroid cancer
125910082
05221 Acute myeloid leukemia
125910082
05220 Chronic myeloid leukemia
125910082
05218 Melanoma
125910082
05211 Renal cell carcinoma
125910082
05219 Bladder cancer
125910082
05215 Prostate cancer
125910082
05213 Endometrial cancer
125910082
05224 Breast cancer
125910082
05223 Non-small cell lung cancer
125910082
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
125910082
05170 Human immunodeficiency virus 1 infection
125910082
05161 Hepatitis B
125910082
05160 Hepatitis C
125910082
05164 Influenza A
125910082
05163 Human cytomegalovirus infection
125910082
05167 Kaposi sarcoma-associated herpesvirus infection
125910082
05165 Human papillomavirus infection
125910082
09171 Infectious disease: bacterial
05132 Salmonella infection
125910082
05135 Yersinia infection
125910082
09164 Neurodegenerative disease
05010 Alzheimer disease
125910082
05022 Pathways of neurodegeneration - multiple diseases
125910082
09165 Substance dependence
05034 Alcoholism
125910082
09167 Endocrine and metabolic disease
04934 Cushing syndrome
125910082
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
125910082
01522 Endocrine resistance
125910082
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
puc01001
]
125910082
Enzymes [BR:
puc01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
125910082
Protein kinases [BR:
puc01001
]
Serine/threonine kinases: STE group
STE7 family
125910082
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Seadorna_VP7
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
125910082
NCBI-ProteinID:
XP_049469743
LinkDB
All DBs
Position
B3
Genome browser
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgagcagcaacggaagcgcctggaggcctttcttacccagaagcagaaggtc
ggggaattgaaggatgacgactttgagaagatcagtgagctgggcgccggcaacggtggt
gtggtgttcaaggtctcccataagccgtctggcctggtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagctgcaggttctacatgag
tgcaactccccatacatcgtgggcttctatggcgcgttctacagcgacggcgagatcagt
atctgtatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctagtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tccgtgcagtcggacatctggagcatggggctatctctggttgagatggcagtcgggagg
tatcccatccctcctcccgatgccaaggagctggagctgatgtttgggtgccaagtggag
ggagatgcggctgagacgccacccaggccgaggacccctggaaggcccctcagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaagctgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcctcataaaaaacccagcagagagagcagatctgaaacaactcatggttcatgccttt
atcaagagatctgatggtgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagtacaccgacccacgcggccggcgtctaa
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