Rattus norvegicus (rat): 170911
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Entry
170911 CDS
T01003
Symbol
Pik3ca
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
KO
K00922
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:
2.7.1.153
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno00562
Inositol phosphate metabolism
rno01100
Metabolic pathways
rno01521
EGFR tyrosine kinase inhibitor resistance
rno01522
Endocrine resistance
rno01524
Platinum drug resistance
rno04012
ErbB signaling pathway
rno04014
Ras signaling pathway
rno04015
Rap1 signaling pathway
rno04024
cAMP signaling pathway
rno04062
Chemokine signaling pathway
rno04066
HIF-1 signaling pathway
rno04068
FoxO signaling pathway
rno04070
Phosphatidylinositol signaling system
rno04071
Sphingolipid signaling pathway
rno04072
Phospholipase D signaling pathway
rno04140
Autophagy - animal
rno04150
mTOR signaling pathway
rno04151
PI3K-Akt signaling pathway
rno04152
AMPK signaling pathway
rno04210
Apoptosis
rno04211
Longevity regulating pathway
rno04213
Longevity regulating pathway - multiple species
rno04218
Cellular senescence
rno04360
Axon guidance
rno04370
VEGF signaling pathway
rno04380
Osteoclast differentiation
rno04510
Focal adhesion
rno04550
Signaling pathways regulating pluripotency of stem cells
rno04611
Platelet activation
rno04613
Neutrophil extracellular trap formation
rno04620
Toll-like receptor signaling pathway
rno04625
C-type lectin receptor signaling pathway
rno04630
JAK-STAT signaling pathway
rno04650
Natural killer cell mediated cytotoxicity
rno04660
T cell receptor signaling pathway
rno04662
B cell receptor signaling pathway
rno04664
Fc epsilon RI signaling pathway
rno04666
Fc gamma R-mediated phagocytosis
rno04668
TNF signaling pathway
rno04670
Leukocyte transendothelial migration
rno04722
Neurotrophin signaling pathway
rno04725
Cholinergic synapse
rno04750
Inflammatory mediator regulation of TRP channels
rno04810
Regulation of actin cytoskeleton
rno04910
Insulin signaling pathway
rno04914
Progesterone-mediated oocyte maturation
rno04915
Estrogen signaling pathway
rno04917
Prolactin signaling pathway
rno04919
Thyroid hormone signaling pathway
rno04923
Regulation of lipolysis in adipocytes
rno04926
Relaxin signaling pathway
rno04929
GnRH secretion
rno04930
Type II diabetes mellitus
rno04931
Insulin resistance
rno04932
Non-alcoholic fatty liver disease
rno04933
AGE-RAGE signaling pathway in diabetic complications
rno04935
Growth hormone synthesis, secretion and action
rno04960
Aldosterone-regulated sodium reabsorption
rno04973
Carbohydrate digestion and absorption
rno05010
Alzheimer disease
rno05017
Spinocerebellar ataxia
rno05020
Prion disease
rno05100
Bacterial invasion of epithelial cells
rno05132
Salmonella infection
rno05135
Yersinia infection
rno05142
Chagas disease
rno05146
Amoebiasis
rno05160
Hepatitis C
rno05161
Hepatitis B
rno05162
Measles
rno05163
Human cytomegalovirus infection
rno05164
Influenza A
rno05165
Human papillomavirus infection
rno05166
Human T-cell leukemia virus 1 infection
rno05167
Kaposi sarcoma-associated herpesvirus infection
rno05168
Herpes simplex virus 1 infection
rno05169
Epstein-Barr virus infection
rno05170
Human immunodeficiency virus 1 infection
rno05171
Coronavirus disease - COVID-19
rno05200
Pathways in cancer
rno05203
Viral carcinogenesis
rno05205
Proteoglycans in cancer
rno05206
MicroRNAs in cancer
rno05207
Chemical carcinogenesis - receptor activation
rno05208
Chemical carcinogenesis - reactive oxygen species
rno05210
Colorectal cancer
rno05211
Renal cell carcinoma
rno05212
Pancreatic cancer
rno05213
Endometrial cancer
rno05214
Glioma
rno05215
Prostate cancer
rno05218
Melanoma
rno05220
Chronic myeloid leukemia
rno05221
Acute myeloid leukemia
rno05222
Small cell lung cancer
rno05223
Non-small cell lung cancer
rno05224
Breast cancer
rno05225
Hepatocellular carcinoma
rno05226
Gastric cancer
rno05230
Central carbon metabolism in cancer
rno05231
Choline metabolism in cancer
rno05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
rno05415
Diabetic cardiomyopathy
rno05417
Lipid and atherosclerosis
rno05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
170911 (Pik3ca)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
170911 (Pik3ca)
04014 Ras signaling pathway
170911 (Pik3ca)
04015 Rap1 signaling pathway
170911 (Pik3ca)
04370 VEGF signaling pathway
170911 (Pik3ca)
04630 JAK-STAT signaling pathway
170911 (Pik3ca)
04668 TNF signaling pathway
170911 (Pik3ca)
04066 HIF-1 signaling pathway
170911 (Pik3ca)
04068 FoxO signaling pathway
170911 (Pik3ca)
04070 Phosphatidylinositol signaling system
170911 (Pik3ca)
04072 Phospholipase D signaling pathway
170911 (Pik3ca)
04071 Sphingolipid signaling pathway
170911 (Pik3ca)
04024 cAMP signaling pathway
170911 (Pik3ca)
04151 PI3K-Akt signaling pathway
170911 (Pik3ca)
04152 AMPK signaling pathway
170911 (Pik3ca)
04150 mTOR signaling pathway
170911 (Pik3ca)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
170911 (Pik3ca)
09143 Cell growth and death
04210 Apoptosis
170911 (Pik3ca)
04218 Cellular senescence
170911 (Pik3ca)
09144 Cellular community - eukaryotes
04510 Focal adhesion
170911 (Pik3ca)
04550 Signaling pathways regulating pluripotency of stem cells
170911 (Pik3ca)
09142 Cell motility
04810 Regulation of actin cytoskeleton
170911 (Pik3ca)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
170911 (Pik3ca)
04613 Neutrophil extracellular trap formation
170911 (Pik3ca)
04620 Toll-like receptor signaling pathway
170911 (Pik3ca)
04625 C-type lectin receptor signaling pathway
170911 (Pik3ca)
04650 Natural killer cell mediated cytotoxicity
170911 (Pik3ca)
04660 T cell receptor signaling pathway
170911 (Pik3ca)
04662 B cell receptor signaling pathway
170911 (Pik3ca)
04664 Fc epsilon RI signaling pathway
170911 (Pik3ca)
04666 Fc gamma R-mediated phagocytosis
170911 (Pik3ca)
04670 Leukocyte transendothelial migration
170911 (Pik3ca)
04062 Chemokine signaling pathway
170911 (Pik3ca)
09152 Endocrine system
04910 Insulin signaling pathway
170911 (Pik3ca)
04923 Regulation of lipolysis in adipocytes
170911 (Pik3ca)
04929 GnRH secretion
170911 (Pik3ca)
04915 Estrogen signaling pathway
170911 (Pik3ca)
04914 Progesterone-mediated oocyte maturation
170911 (Pik3ca)
04917 Prolactin signaling pathway
170911 (Pik3ca)
04926 Relaxin signaling pathway
170911 (Pik3ca)
04935 Growth hormone synthesis, secretion and action
170911 (Pik3ca)
04919 Thyroid hormone signaling pathway
170911 (Pik3ca)
09154 Digestive system
04973 Carbohydrate digestion and absorption
170911 (Pik3ca)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
170911 (Pik3ca)
09156 Nervous system
04725 Cholinergic synapse
170911 (Pik3ca)
04722 Neurotrophin signaling pathway
170911 (Pik3ca)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
170911 (Pik3ca)
09158 Development and regeneration
04360 Axon guidance
170911 (Pik3ca)
04380 Osteoclast differentiation
170911 (Pik3ca)
09149 Aging
04211 Longevity regulating pathway
170911 (Pik3ca)
04213 Longevity regulating pathway - multiple species
170911 (Pik3ca)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
170911 (Pik3ca)
05206 MicroRNAs in cancer
170911 (Pik3ca)
05205 Proteoglycans in cancer
170911 (Pik3ca)
05207 Chemical carcinogenesis - receptor activation
170911 (Pik3ca)
05208 Chemical carcinogenesis - reactive oxygen species
170911 (Pik3ca)
05203 Viral carcinogenesis
170911 (Pik3ca)
05230 Central carbon metabolism in cancer
170911 (Pik3ca)
05231 Choline metabolism in cancer
170911 (Pik3ca)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
170911 (Pik3ca)
09162 Cancer: specific types
05210 Colorectal cancer
170911 (Pik3ca)
05212 Pancreatic cancer
170911 (Pik3ca)
05225 Hepatocellular carcinoma
170911 (Pik3ca)
05226 Gastric cancer
170911 (Pik3ca)
05214 Glioma
170911 (Pik3ca)
05221 Acute myeloid leukemia
170911 (Pik3ca)
05220 Chronic myeloid leukemia
170911 (Pik3ca)
05218 Melanoma
170911 (Pik3ca)
05211 Renal cell carcinoma
170911 (Pik3ca)
05215 Prostate cancer
170911 (Pik3ca)
05213 Endometrial cancer
170911 (Pik3ca)
05224 Breast cancer
170911 (Pik3ca)
05222 Small cell lung cancer
170911 (Pik3ca)
05223 Non-small cell lung cancer
170911 (Pik3ca)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
170911 (Pik3ca)
05170 Human immunodeficiency virus 1 infection
170911 (Pik3ca)
05161 Hepatitis B
170911 (Pik3ca)
05160 Hepatitis C
170911 (Pik3ca)
05171 Coronavirus disease - COVID-19
170911 (Pik3ca)
05164 Influenza A
170911 (Pik3ca)
05162 Measles
170911 (Pik3ca)
05168 Herpes simplex virus 1 infection
170911 (Pik3ca)
05163 Human cytomegalovirus infection
170911 (Pik3ca)
05167 Kaposi sarcoma-associated herpesvirus infection
170911 (Pik3ca)
05169 Epstein-Barr virus infection
170911 (Pik3ca)
05165 Human papillomavirus infection
170911 (Pik3ca)
09171 Infectious disease: bacterial
05132 Salmonella infection
170911 (Pik3ca)
05135 Yersinia infection
170911 (Pik3ca)
05100 Bacterial invasion of epithelial cells
170911 (Pik3ca)
09174 Infectious disease: parasitic
05146 Amoebiasis
170911 (Pik3ca)
05142 Chagas disease
170911 (Pik3ca)
09164 Neurodegenerative disease
05010 Alzheimer disease
170911 (Pik3ca)
05017 Spinocerebellar ataxia
170911 (Pik3ca)
05020 Prion disease
170911 (Pik3ca)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
170911 (Pik3ca)
05418 Fluid shear stress and atherosclerosis
170911 (Pik3ca)
05415 Diabetic cardiomyopathy
170911 (Pik3ca)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
170911 (Pik3ca)
04932 Non-alcoholic fatty liver disease
170911 (Pik3ca)
04931 Insulin resistance
170911 (Pik3ca)
04933 AGE-RAGE signaling pathway in diabetic complications
170911 (Pik3ca)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
170911 (Pik3ca)
01524 Platinum drug resistance
170911 (Pik3ca)
01522 Endocrine resistance
170911 (Pik3ca)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
rno04131
]
170911 (Pik3ca)
Enzymes [BR:
rno01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase
170911 (Pik3ca)
Membrane trafficking [BR:
rno04131
]
Endocytosis
Rab GTPases and associated proteins
Rab associated proteins
170911 (Pik3ca)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI3Ka
PI3_PI4_kinase
PI3K_C2
PI3K_rbd
PI3K_p85B
DUF2321
ABC1
Ribosomal_S15
Motif
Other DBs
NCBI-GeneID:
170911
NCBI-ProteinID:
NP_596890
RGD:
620916
Ensembl:
ENSRNOG00000056371
UniProt:
A0A0G2K344
LinkDB
All DBs
Position
2:117103643..117177411
Genome browser
AA seq
1068 aa
AA seq
DB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPID
SFTMPSYSRRISTATPYMNGETATKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq
3207 nt
NT seq
+upstream
nt +downstream
nt
atgcctccacgaccatcttcgggtgaactgtggggcatccacttgatgcccccacgaatc
ctagtggaatgtttactcccaaatggaatgatagtgactttagaatgcctccgtgaggcc
acactagtcaccatcaagcatgaactgttcaaagaggccaggaaataccctctccatcag
cttctgcaagatgaatcatcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaatttttcgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaaccgagaaattggttttgtt
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtccaagacttccga
aggaacattctgaatgtttgcaaagaagccgtggacctgcgggatctcaactcgcctcat
agcagagcaatgtatgtctaccctccaaatgtcgagtcttccccagaactgccaaagcac
atctacaacaagttagataaaggacaaatcatagtggtgatttgggtgatagtctctcca
aacaacgacaagcagaagtacactctgaagatcaaccatgactgcgtgccagagcaagtc
attgctgaggccatcaggaagaagacccggagcatgttgctgtcctcggagcagctgaaa
ctctgtgtcttagaataccagggcaagtacattctcaaagtgtgtggctgtgatgagtac
ttcctagagaagtaccctctgagtcagtacaagtacataagaagctgtataatgctgggg
aggatgcccaacttgatgctgatggccaaggagagcctgtactctcagctgccgatcgat
agcttcacaatgccatcctactccaggcgcatttccacagcgacaccctatatgaacggg
gagactgctacgaaatccctctgggttataaatagcgcgctcagaataaaaattctgtgt
gcaacctatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaatactcaaagagtcccttgttccaat
cctaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgcc
cgcctttgcctttcaatctgctctgttaaaggccgaaagggtgctaaggaggagcactgt
ccgttggcctggggaaacataaacttgtttgattatacagacaccctagtgtccgggaaa
atggctttgaatctctggcctgtaccacatgggttggaagatctgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgattggttc
agcagtgtggtgaagtttccagatatgtctgtgatcgaagagcatgccaattggtctgtg
tcccgagaagccggattcagttactctcatacaggactgagtaacagactagccagagac
aatgagttaagagaaaatgacaaggaacagctccgagcactttgtacccgggacccactg
tctgaaatcactgaacaagagaaagacttcctatggagccacagacactactgtgtaact
attcctgaaatcctacccaaattgcttctgtctgtcaagtggaattccagagatgaagtg
gcccagatgtactgcttagtaaaagattggcctccaatcaaaccagagcaagccatggag
ctcctggactgtaactacccagaccccatggttcggagctttgctgtccggtgcttggaa
aaatacttaacagatgacaaactttctcagtacctcatccagcttgtacaggtcttaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcactgacaaat
caaaggattggccattttttcttttggcatttaaaatctgagatgcacaataagactgtc
agtcagaggttcggcctgctgttggagtcctactgccgtgcctgtgggatgtatctgaag
cacctgaacagacaggtagaggccatggagaagctcatcaatctaactgacatcctcaag
caggagaagaaggatgagacacagaaggtacagatgaagttcttggttgaacagatgaga
cagccagatttcatggatgctttgcagggttttctgtcccctctaaatcctgctcatcaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagctactgtttcagaacaatgagatcatc
tttaaaaatggcgatgacttacggcaagacatgttaacccttcagatcatccgaatcatg
gagaacatctggcaaaaccaaggccttgaccttcgcatgctaccttatggctgtctatcc
attggggactgtgtgggtctcatcgaggtggtgagaaactctcacaccatcatgcagatt
cagtgcaaaggaggcctgaagggggcactgcagttcaacagccacacgctgcatcagtgg
ctcaaggacaagaacaagggcgagatatatgatgcagccattgacctgttcactcggtcc
tgcgctgggtactgcgtggcaacctttatcttgggaattggagaccggcacaacagcaac
atcatggtgaaagatgacggacagctgtttcatatagattttgggcactttttggatcac
aagaagaaaaaatttggctataaacgggaacgtgtgccgtttgttttgacgcaggatttc
ttaatagtgattagtaaaggagcacaagagtacacaaagaccagagagtttgagaggttt
caggagatgtgttacaaggcgtacctagcaattcggcagcatgccaatctcttcatcaac
cttttctccatgatgcttggctccggaatgccagaactgcagtctttcgatgatattgca
tatattcgaaagactctagccttagacaaaactgagcaagaggctctggagtatttcaca
aagcaaatgaatgacgcacatcatggtggctggacaacaaaaatggactggatcttccac
accatcaagcagcatgcattgaactga
DBGET
integrated database retrieval system