Sorex araneus (European shrew): 101537449
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Entry
101537449 CDS
T07854
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
sara
Sorex araneus (European shrew)
Pathway
sara00270
Cysteine and methionine metabolism
sara00480
Glutathione metabolism
sara01100
Metabolic pathways
sara01240
Biosynthesis of cofactors
sara04216
Ferroptosis
Module
sara_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
sara00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
101537449 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
101537449 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
101537449 (GCLC)
Enzymes [BR:
sara01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
101537449 (GCLC)
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Paralog
GFIT
Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
101537449
NCBI-ProteinID:
XP_004605919
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All DBs
Position
Unknown
AA seq
637 aa
AA seq
DB search
MGLLSQGSPLSWEETRRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKAQLVLSGEEVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLEENQALCTITSFPRLGCPGFTLPEFKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFPEDDEAARASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGHVSDIDCRWGVI
SASVDDRTREERGLEPLKKNNYRISKSRYDSIDSYLSVCGEKYNDIDLTIDKEIYQQLLQ
EGIDHLLAQHVAHLFIRDPLTLFEEKINLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGMFYFRKDICKGGSAVVDGRGKGQNSSEQAVEEYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIASHPSYKQDSVITDEMNYS
LLLKCNQIANELCECPELLGPAFRKAKYSGSKTDSSN
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctgagctgggaggagacccggcgccacgccgac
cacgtgcggcgccacggcatcctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaagtggggcgacgaggtggaatacatgttggtatcttttgatcat
gaaaataaaaaagcccagttggtcctgtctggagaggaagttcttgaaaccctacaagaa
aagggagaaaggacaaacccaaaccatcctaccctttggaggcccgagtatgggagctac
atgattgaagggacgcctggacagccgtatggaggaacaatgtccgagttcaatacagtt
gaagataacatgaggaaacgccggaaggaggcaacttctttattagaagaaaatcaggct
ctttgtacaataacatcatttccaagattaggttgtcccgggttcacgctgcctgagttc
aaacccaacccggttgaaggaggagcttccaagtccctcttctttcccgacgaagcaata
aacaagcacccccgcttcagtaccttaacaagaaatattcgacataggagaggagaaaag
gttgttatcaatgtaccaatatttaaggacaagaacacaccatctccatttattgagaca
tttcctgaggatgatgaagcagcaagggcttctaaacccgaccatatttacatggatgcc
atgggatttgggatgggcaattgctgtcttcaggtaacattccaagcttgcagcatatct
gaggccagatacctgtacgatcagttggccactatatgtcccattgttatggctttgagt
gccgcgtctcctttctaccgaggccatgtgtctgacattgactgtcgctggggagtgatt
tccgcatccgtagatgacagaactcgggaggagcgaggactggagccgctgaagaaaaat
aattataggatcagtaaatcccgctatgattcaatagacagttacttatcggtgtgcggt
gagaaatacaatgacattgatctgacaatcgacaaagaaatttaccaacaactgttgcaa
gaaggcatcgaccatcttctggcccagcatgtggcgcatctctttattagagacccactg
actctgtttgaagagaaaataaacctggatgatgccaatgagtctgaccattttgagaat
attcagtccacaaattggcagacaatgaggtttaagccccctcctccaaactcagatatt
ggatggagagtggaattccgacccatggaggttcagctgacagactttgagaactcggca
tatgtagtgtttgtggtcctgcttaccagagtgatcctttcatacaaattggatttcctc
attccattgtcaaaggtcgatgaaaacatgaaagtagcacagaaacgggatgccgtcctg
cagggaatgttctatttccggaaggatatttgcaaaggtggcagcgcggtggtggatggc
cgtggcaagggccagaacagcagcgagcaggccgtggaggagtacaccctcatgagcata
gacaccatcatcaacgggaaggaaggcgtgtttcccgggctcatccctattctcaactct
tacctggagaacatggaagtggatgtggacaccagatgtagtattctcaactacctgaag
ctaattaagaagagagcgtccggagaactaatgacagtcgccagatggatgagggagttt
attgcaagccatcccagctacaagcaagatagtgtaataactgatgaaatgaactatagc
cttcttttgaagtgtaaccaaattgcaaatgaattgtgtgaatgcccagagttacttgga
ccagcatttcggaaagcaaaatacagcggaagtaaaactgactcttccaactaa
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