Sorex araneus (European shrew): 101539776 Help Entry 101539776         CDS       T07854                                  Symbol ADCY4 Name (RefSeq) adenylate cyclase type 4   KO K08044   adenylate cyclase 4 [EC:4.6.1.1] Organism sara  Sorex araneus (European shrew) Pathway sara00230   Purine metabolism sara01100   Metabolic pathways sara01522   Endocrine resistance sara04015   Rap1 signaling pathway sara04020   Calcium signaling pathway sara04022   cGMP-PKG signaling pathway sara04024   cAMP signaling pathway sara04062   Chemokine signaling pathway sara04072   Phospholipase D signaling pathway sara04114   Oocyte meiosis sara04211   Longevity regulating pathway sara04213   Longevity regulating pathway - multiple species sara04261   Adrenergic signaling in cardiomyocytes sara04270   Vascular smooth muscle contraction sara04371   Apelin signaling pathway sara04540   Gap junction sara04611   Platelet activation sara04713   Circadian entrainment sara04714   Thermogenesis sara04723   Retrograde endocannabinoid signaling sara04724   Glutamatergic synapse sara04725   Cholinergic synapse sara04727   GABAergic synapse sara04742   Taste transduction sara04750   Inflammatory mediator regulation of TRP channels sara04911   Insulin secretion sara04912   GnRH signaling pathway sara04913   Ovarian steroidogenesis sara04914   Progesterone-mediated oocyte maturation sara04915   Estrogen signaling pathway sara04916   Melanogenesis sara04918   Thyroid hormone synthesis sara04921   Oxytocin signaling pathway sara04923   Regulation of lipolysis in adipocytes sara04925   Aldosterone synthesis and secretion sara04926   Relaxin signaling pathway sara04927   Cortisol synthesis and secretion sara04928   Parathyroid hormone synthesis, secretion and action sara04934   Cushing syndrome sara04935   Growth hormone synthesis, secretion and action sara04970   Salivary secretion sara04971   Gastric acid secretion sara04972   Pancreatic secretion sara04976   Bile secretion sara05032   Morphine addiction sara05163   Human cytomegalovirus infection sara05166   Human T-cell leukemia virus 1 infection sara05200   Pathways in cancer sara05207   Chemical carcinogenesis - receptor activation sara05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:sara00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     101539776 (ADCY4)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     101539776 (ADCY4)    04371 Apelin signaling pathway     101539776 (ADCY4)    04020 Calcium signaling pathway     101539776 (ADCY4)    04072 Phospholipase D signaling pathway     101539776 (ADCY4)    04024 cAMP signaling pathway     101539776 (ADCY4)    04022 cGMP-PKG signaling pathway     101539776 (ADCY4)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     101539776 (ADCY4)   09144 Cellular community - eukaryotes    04540 Gap junction     101539776 (ADCY4)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101539776 (ADCY4)    04062 Chemokine signaling pathway     101539776 (ADCY4)   09152 Endocrine system    04911 Insulin secretion     101539776 (ADCY4)    04923 Regulation of lipolysis in adipocytes     101539776 (ADCY4)    04912 GnRH signaling pathway     101539776 (ADCY4)    04913 Ovarian steroidogenesis     101539776 (ADCY4)    04915 Estrogen signaling pathway     101539776 (ADCY4)    04914 Progesterone-mediated oocyte maturation     101539776 (ADCY4)    04921 Oxytocin signaling pathway     101539776 (ADCY4)    04926 Relaxin signaling pathway     101539776 (ADCY4)    04935 Growth hormone synthesis, secretion and action     101539776 (ADCY4)    04918 Thyroid hormone synthesis     101539776 (ADCY4)    04928 Parathyroid hormone synthesis, secretion and action     101539776 (ADCY4)    04916 Melanogenesis     101539776 (ADCY4)    04925 Aldosterone synthesis and secretion     101539776 (ADCY4)    04927 Cortisol synthesis and secretion     101539776 (ADCY4)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     101539776 (ADCY4)    04270 Vascular smooth muscle contraction     101539776 (ADCY4)   09154 Digestive system    04970 Salivary secretion     101539776 (ADCY4)    04971 Gastric acid secretion     101539776 (ADCY4)    04972 Pancreatic secretion     101539776 (ADCY4)    04976 Bile secretion     101539776 (ADCY4)   09156 Nervous system    04724 Glutamatergic synapse     101539776 (ADCY4)    04727 GABAergic synapse     101539776 (ADCY4)    04725 Cholinergic synapse     101539776 (ADCY4)    04723 Retrograde endocannabinoid signaling     101539776 (ADCY4)   09157 Sensory system    04742 Taste transduction     101539776 (ADCY4)    04750 Inflammatory mediator regulation of TRP channels     101539776 (ADCY4)   09149 Aging    04211 Longevity regulating pathway     101539776 (ADCY4)    04213 Longevity regulating pathway - multiple species     101539776 (ADCY4)   09159 Environmental adaptation    04713 Circadian entrainment     101539776 (ADCY4)    04714 Thermogenesis     101539776 (ADCY4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101539776 (ADCY4)    05207 Chemical carcinogenesis - receptor activation     101539776 (ADCY4)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101539776 (ADCY4)    05163 Human cytomegalovirus infection     101539776 (ADCY4)   09165 Substance dependence    05032 Morphine addiction     101539776 (ADCY4)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     101539776 (ADCY4)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101539776 (ADCY4)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101539776 (ADCY4) Enzymes [BR:sara01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      101539776 (ADCY4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N CD52 Motif Other DBs NCBI-GeneID:  101539776 NCBI-ProteinID:  XP_004609493 LinkDB All DBs Position Unknown AA seq 1074 aa AA seqDB search MARLFSPRPPPSEDLFYETYYSLSQQYPLMLLLLLIVLGALLALLAVAWASGRELTSDPG FLTIVLCALGGFSLLLGLASREQWLQRWTRPLSGFVWVALLALGHSFLFTGGVVSAWDQV SFFLFVIFTVYAMLPLGMWDAVAAGLTSSLSHLLAVGLYLGPQPDSRPALLPQLAANAVL FLCGNVAGAYHKALMERALRATFREALTSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG AYAVEAAAMEHRDPYLRDLGEPTYLVIDPRAEEDEKGTAGGLLSSLEGPKMRPSLLMTRY LESWGAAKPFAHLSHVESPVSTSTPLPEKALASFSPQWSLDRSRTPRGLDDELDTGDAKF FQVIEQLNSQNQWKQSKDFSPLTLLFREKEMEKEYRLSALPAFKYYAACTFVVFLSNFII QMLVTNRPPALTITYSVTFLLFLLLLFVCFSEHLTRCVLKGPKMLHWLPVLSGLVATRPG LRVALGTATILLVFTMAIISLFFLPATSSCPFHTHNTSSVAANLSWELPGSLPLISIPYS MHCCVLAFFSCSIYLHMSFELKLLLLLLGLAASCSLFLHSHAWLSDCLIARLYLGPSRPG VLKEPKLVGAVSFFIFFFTLLFLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLE NVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLN EIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFA MALGAKLEVINKHSFNNFHLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVL GKIQVTEETAGALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDFTRAGPPSATLG NT seq 3225 nt NT seq  +upstreamnt  +downstreamnt atggcgcgcctgttcagcccccggccgccccccagcgaggacctcttctacgagacctac tacagcctgagccagcagtacccgctgatgctgctgctgctgctcatcgtgctcggcgcg ctcctggcgctgctggcggtcgcctgggccagcggcagggagctgacctcagacccaggc ttcctgaccattgtgctgtgtgctctgggcggcttctccctgctgctgggtctggcttcc cgtgagcagtggctgcagcgctggacacgacccctctcgggcttcgtgtgggtggcactg cttgcccttggtcatagcttcctgttcactgggggtgtggtgagcgcctgggaccaggtg tccttcttcctctttgtcatcttcactgtgtacgctatgctgcccttgggcatgtgggat gcagtagctgcaggcctcacctcatcactctcacacctgctggccgtcggtctctatctt gggccccaaccagactcacggcctgcgctgctgccacagctggcggctaacgcggtgctg ttcctgtgcgggaacgtggcgggggcgtaccacaaggcgctgatggagcgcgcgctgcgc gccaccttccgggaggcgctgacctcgctgcactcgcgccgccggctggacaccgagaag aagcaccaggagcaccttctcttgtccatccttccggcctacctggcccgcgagatgaag gcggagatcatggcccggctgcaggctgggcagggctcccggcccgagagtaccaacaac ttccacagcctctatgtcaagagacaccagggagtgagcgtgctgtatgccgacatcgtg ggcttcacgcggctggccagtgagtgctcgcctaaggagttggtgctcatgctcaacgag ctcttcggcaagtttgaccagattgccaaggagcatgaatgcatgcggatcaagatcctg ggagactgttactactgtgtctcaggcctgccactctcgctgccagaccacgccatcaac tgcgtgcgcatggggctggacatgtgtcgggccatcaggaagcttcgggcagccacgggc gtggatatcaacatgcgtgtgggggtgcactctggcagcgtgctctgcggagtcatcggg ctgcagaagtggcagtatgacgtgtggtcccatgatgtcacgctggccaatcacatggag gcaggtggcgtgccagggcgggtccacatcacaggagcgaccctggccctactggcaggg gcttacgcggtggaggctgcagctatggaacaccgggacccttaccttcgggatctgggg gagcctacctacctagtcatcgatccccgggccgaggaggatgaaaagggcaccgccgga ggcttgctgtcttctcttgagggccccaaaatgcgcccctccctgctgatgacccgctac ctggagtcctggggtgcagccaagccttttgctcacctgagccacgtggagagccccgtg tccacctccaccccgctcccggagaaggctctggcttccttcagcccccagtggagcctg gaccggagccgcaccccccggggactcgacgatgaactggacacaggggatgccaagttc ttccaggtcatcgagcagctcaactcgcagaaccagtggaagcagtcgaaggacttcagc ccactgacactgctcttccgtgagaaggagatggaaaaagagtaccggctctccgcgctc cctgccttcaagtactacgcagcctgcacctttgtggtcttcctctccaacttcatcatc cagatgctagtgaccaacaggcccccagctctgaccatcacctacagtgtcaccttcctc ctcttcctcctcctcctcttcgtttgcttctcagagcacctgacgaggtgtgtcttgaaa ggtcccaagatgctgcactggctgcctgtcctctctggcctggtggccaccaggcccgga ctgcgagtcgccctgggcacggccaccatcctcctggtcttcaccatggccatcatcagc ctgttcttcttaccggcgacctctagctgtcctttccacactcacaacacgtcttcggtg gccgccaacctctcctgggagctccccggctccctgcctctcatcagcatcccctactcc atgcactgctgcgtgctggctttcttctcctgctccatctacctgcatatgagcttcgag ttgaagcttctgctgctgctgctcgggctggccgcctcctgctccctcttcctgcactcc cacgcctggctgtccgactgcctcatcgcccgcctctacctgggcccctccaggccaggg gtgctgaaggagcccaaactggtgggcgctgtctccttcttcatcttcttcttcaccctc ctatttctggcccgccagaatgaatattactgccgcctggacttcctgtggaagaaaaag ctgcggcaggagcgggaggagactgagactatggagaacctgactcggctgctcttggag aacgtgctcccggcacacgtggccccccagttcatcggccagaaccggcgcaatgaggac ctctaccaccagtcctacgagtgcgtctgtgtgctcttcgcctcggtccctgactttaag gagttctactctgaatccaacatcaaccacgaggggctcgagtgtctgcggctactcaat gagatcattgctgattttgatgagctactctccaagcccaagttcagtggtgtggagaag atcaaaaccattggcagcacttacatggcggctacaggcttaaatgccacctcggggcag gatgcacagcaggatgctgagcgcagctgtagccacctgggcaccatggtggaatttgcg atggccctgggggctaagctggaggttatcaacaagcattccttcaacaacttccacctg cgtgtggggctgaatcatggacctgtagtggctggagtgattggagcccagaagccacag tacgacatctggggcaacacagtgaacgtggccagccgcatggagagtacaggagtgttg ggcaagatccaagtgactgaagagacagctggggcgctgcagtccttaggctacacctgc tacagccggggtgtcatcaaggtcaagggcaaggggcagctctgcacctacttcctgaac acagacttcactcgagccggtcctccctcggccaccctgggctga

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