Suncus etruscus (white-toothed pygmy shrew): 125999333
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Entry
125999333 CDS
T09902
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
setr
Suncus etruscus (white-toothed pygmy shrew)
Pathway
setr01521
EGFR tyrosine kinase inhibitor resistance
setr01522
Endocrine resistance
setr04010
MAPK signaling pathway
setr04012
ErbB signaling pathway
setr04068
FoxO signaling pathway
setr04270
Vascular smooth muscle contraction
setr04650
Natural killer cell mediated cytotoxicity
setr04720
Long-term potentiation
setr04726
Serotonergic synapse
setr04730
Long-term depression
setr04810
Regulation of actin cytoskeleton
setr04910
Insulin signaling pathway
setr04914
Progesterone-mediated oocyte maturation
setr04928
Parathyroid hormone synthesis, secretion and action
setr05010
Alzheimer disease
setr05022
Pathways of neurodegeneration - multiple diseases
setr05034
Alcoholism
setr05160
Hepatitis C
setr05161
Hepatitis B
setr05200
Pathways in cancer
setr05205
Proteoglycans in cancer
setr05208
Chemical carcinogenesis - reactive oxygen species
setr05210
Colorectal cancer
setr05211
Renal cell carcinoma
setr05212
Pancreatic cancer
setr05213
Endometrial cancer
setr05214
Glioma
setr05215
Prostate cancer
setr05218
Melanoma
setr05219
Bladder cancer
setr05220
Chronic myeloid leukemia
setr05221
Acute myeloid leukemia
setr05223
Non-small cell lung cancer
setr05224
Breast cancer
setr05225
Hepatocellular carcinoma
setr05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
setr00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
125999333 (ARAF)
04012 ErbB signaling pathway
125999333 (ARAF)
04068 FoxO signaling pathway
125999333 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
125999333 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
125999333 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
125999333 (ARAF)
04914 Progesterone-mediated oocyte maturation
125999333 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
125999333 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
125999333 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
125999333 (ARAF)
04720 Long-term potentiation
125999333 (ARAF)
04730 Long-term depression
125999333 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
125999333 (ARAF)
05205 Proteoglycans in cancer
125999333 (ARAF)
05208 Chemical carcinogenesis - reactive oxygen species
125999333 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
125999333 (ARAF)
05212 Pancreatic cancer
125999333 (ARAF)
05225 Hepatocellular carcinoma
125999333 (ARAF)
05226 Gastric cancer
125999333 (ARAF)
05214 Glioma
125999333 (ARAF)
05221 Acute myeloid leukemia
125999333 (ARAF)
05220 Chronic myeloid leukemia
125999333 (ARAF)
05218 Melanoma
125999333 (ARAF)
05211 Renal cell carcinoma
125999333 (ARAF)
05219 Bladder cancer
125999333 (ARAF)
05215 Prostate cancer
125999333 (ARAF)
05213 Endometrial cancer
125999333 (ARAF)
05224 Breast cancer
125999333 (ARAF)
05223 Non-small cell lung cancer
125999333 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
125999333 (ARAF)
05160 Hepatitis C
125999333 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
125999333 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
125999333 (ARAF)
09165 Substance dependence
05034 Alcoholism
125999333 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
125999333 (ARAF)
01522 Endocrine resistance
125999333 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
setr01001
]
125999333 (ARAF)
Enzymes [BR:
setr01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
125999333 (ARAF)
Protein kinases [BR:
setr01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
125999333 (ARAF)
BRITE hierarchy
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
Pkinase_fungal
Kdo
Motif
Other DBs
NCBI-GeneID:
125999333
NCBI-ProteinID:
XP_049623369
LinkDB
All DBs
Position
X:50178580..50189957
Genome browser
AA seq
607 aa
AA seq
DB search
MEPARSLPANEAEPTRTVGTVKVYLPNKQRTVVTVRDGMSVYNSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGTRHHEAPLNHPLKEPL
TRQSSSSFTQNCSPKHFPFPAPASAPLQRIRSTSTPNVHMVSTTAPMDSNLLQFTAQNFS
TESVGGRCGGDGAAWVSPSLASVSSGRKSPHSKSPSEQRERKSLADEKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFHGRWHGDVAVKVLKVMTAYLASFLHSLTLPFPACR
KTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDY
LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIR
MQDPNPYSFQSDVYAYGVVLYELMTSSLPYSHIGSRDQIIFMVGRGYLSPDLSKVSSNCP
KAMRRLLSDCLKFKREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLL
SAARPVP
NT seq
1824 nt
NT seq
+upstream
nt +downstream
nt
atggagcctgcacggagcctccctgccaatgaggctgagccaacccggacagtgggcact
gtcaaagtatacttacctaacaagcaacgcacggtggtaactgtccgggatggcatgagt
gtctacaactctttagacaaggccctcaaggtgaggggtctcaatcaagattgctgtgtg
gtttaccgactcatcaaggggcgaaagacagtcactgcctgggacacagccattgcccct
ttggatggtgaagagctcattgtggaggttctcgaagatgtgccactgaccatgcacaat
tttgtacgaaagacgttctttagtttggctttctgtgacttctgtcttaagtttctgttc
catggtttccgctgccaaacatgtggctacaagttccaccaacattgttcctccaaagtg
cccacagtctgtgtcgatatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtctggagggaccagacaccatgaggcgcctttgaatcaccccttgaaggagccacta
acccgtcagagttccagctccttcacccagaactgcagccccaagcacttccccttccct
gccccagccagtgcccccctccagcgcatccgttccacatccacccccaacgtccatatg
gttagcacaacagcccccatggactctaacctcctccagttcactgcccagaatttcagc
actgaatctgttggtggtagatgtggaggtgatggagccgcttgggtgagtcccagccta
gccagtgtgtcctcagggaggaagtctccacattccaaatccccatcagagcagcgggag
cggaagtccttggctgatgagaagaagaaagtgaagaacctggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagctgctgaagaggattgggacaggctca
tttggcacggtgtttcatgggcggtggcatggtgatgtggctgtgaaggtgctcaaggta
atgactgcatatcttgctagtttcctccattccctgacactgcccttccctgcctgcagg
aaaactcgacatgtcaacatcttgctgttcatgggcttcatgacccggccaggatttgcc
attattacacaatggtgtgaaggttccagtctctaccaccacctgcatgttgccgacaca
cgctttgacatggtccagcttattgatgtagcccggcagactgcccagggcatggactac
ctccatgccaagaacatcatccaccgagatctcaagtctaataatatcttcttacatgag
gggctcacagtgaagattggtgactttggcctggccacggtgaagacacgatggagtggg
gcacagcccttggagcagccctcaggctcagtgctttggatggcagctgaggtgattcga
atgcaggacccaaacccatacagcttccagtcagatgtctatgcctacggggttgtactc
tatgagctgatgacaagttcactgccttatagccacattggcagtcgtgaccagattatc
tttatggttggccgtggctatctgtccccggacctcagcaaagtttccagcaactgcccc
aaagccatgcggcgcctgctatctgattgtctcaagttcaagagggaagaacggcctctc
ttcccccagatcctggccacgattgagctgcttcagcgatcactccccaagattgagcgg
agtgcctccgaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctactc
agcgcagcccgcccagtaccttag
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