KEGG   Suncus etruscus (white-toothed pygmy shrew): 125999333
Entry
125999333         CDS       T09902                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
setr  Suncus etruscus (white-toothed pygmy shrew)
Pathway
setr01521  EGFR tyrosine kinase inhibitor resistance
setr01522  Endocrine resistance
setr04010  MAPK signaling pathway
setr04012  ErbB signaling pathway
setr04068  FoxO signaling pathway
setr04270  Vascular smooth muscle contraction
setr04650  Natural killer cell mediated cytotoxicity
setr04720  Long-term potentiation
setr04726  Serotonergic synapse
setr04730  Long-term depression
setr04810  Regulation of actin cytoskeleton
setr04910  Insulin signaling pathway
setr04914  Progesterone-mediated oocyte maturation
setr04928  Parathyroid hormone synthesis, secretion and action
setr05010  Alzheimer disease
setr05022  Pathways of neurodegeneration - multiple diseases
setr05034  Alcoholism
setr05160  Hepatitis C
setr05161  Hepatitis B
setr05200  Pathways in cancer
setr05205  Proteoglycans in cancer
setr05208  Chemical carcinogenesis - reactive oxygen species
setr05210  Colorectal cancer
setr05211  Renal cell carcinoma
setr05212  Pancreatic cancer
setr05213  Endometrial cancer
setr05214  Glioma
setr05215  Prostate cancer
setr05218  Melanoma
setr05219  Bladder cancer
setr05220  Chronic myeloid leukemia
setr05221  Acute myeloid leukemia
setr05223  Non-small cell lung cancer
setr05224  Breast cancer
setr05225  Hepatocellular carcinoma
setr05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:setr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125999333 (ARAF)
   04012 ErbB signaling pathway
    125999333 (ARAF)
   04068 FoxO signaling pathway
    125999333 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125999333 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    125999333 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    125999333 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    125999333 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    125999333 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    125999333 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    125999333 (ARAF)
   04720 Long-term potentiation
    125999333 (ARAF)
   04730 Long-term depression
    125999333 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125999333 (ARAF)
   05205 Proteoglycans in cancer
    125999333 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    125999333 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    125999333 (ARAF)
   05212 Pancreatic cancer
    125999333 (ARAF)
   05225 Hepatocellular carcinoma
    125999333 (ARAF)
   05226 Gastric cancer
    125999333 (ARAF)
   05214 Glioma
    125999333 (ARAF)
   05221 Acute myeloid leukemia
    125999333 (ARAF)
   05220 Chronic myeloid leukemia
    125999333 (ARAF)
   05218 Melanoma
    125999333 (ARAF)
   05211 Renal cell carcinoma
    125999333 (ARAF)
   05219 Bladder cancer
    125999333 (ARAF)
   05215 Prostate cancer
    125999333 (ARAF)
   05213 Endometrial cancer
    125999333 (ARAF)
   05224 Breast cancer
    125999333 (ARAF)
   05223 Non-small cell lung cancer
    125999333 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    125999333 (ARAF)
   05160 Hepatitis C
    125999333 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125999333 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    125999333 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    125999333 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125999333 (ARAF)
   01522 Endocrine resistance
    125999333 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:setr01001]
    125999333 (ARAF)
Enzymes [BR:setr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     125999333 (ARAF)
Protein kinases [BR:setr01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   125999333 (ARAF)
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal Kdo
Other DBs
NCBI-GeneID: 125999333
NCBI-ProteinID: XP_049623369
LinkDB
Position
X:50178580..50189957
AA seq 607 aa
MEPARSLPANEAEPTRTVGTVKVYLPNKQRTVVTVRDGMSVYNSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGTRHHEAPLNHPLKEPL
TRQSSSSFTQNCSPKHFPFPAPASAPLQRIRSTSTPNVHMVSTTAPMDSNLLQFTAQNFS
TESVGGRCGGDGAAWVSPSLASVSSGRKSPHSKSPSEQRERKSLADEKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFHGRWHGDVAVKVLKVMTAYLASFLHSLTLPFPACR
KTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDY
LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIR
MQDPNPYSFQSDVYAYGVVLYELMTSSLPYSHIGSRDQIIFMVGRGYLSPDLSKVSSNCP
KAMRRLLSDCLKFKREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLL
SAARPVP
NT seq 1824 nt   +upstreamnt  +downstreamnt
atggagcctgcacggagcctccctgccaatgaggctgagccaacccggacagtgggcact
gtcaaagtatacttacctaacaagcaacgcacggtggtaactgtccgggatggcatgagt
gtctacaactctttagacaaggccctcaaggtgaggggtctcaatcaagattgctgtgtg
gtttaccgactcatcaaggggcgaaagacagtcactgcctgggacacagccattgcccct
ttggatggtgaagagctcattgtggaggttctcgaagatgtgccactgaccatgcacaat
tttgtacgaaagacgttctttagtttggctttctgtgacttctgtcttaagtttctgttc
catggtttccgctgccaaacatgtggctacaagttccaccaacattgttcctccaaagtg
cccacagtctgtgtcgatatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtctggagggaccagacaccatgaggcgcctttgaatcaccccttgaaggagccacta
acccgtcagagttccagctccttcacccagaactgcagccccaagcacttccccttccct
gccccagccagtgcccccctccagcgcatccgttccacatccacccccaacgtccatatg
gttagcacaacagcccccatggactctaacctcctccagttcactgcccagaatttcagc
actgaatctgttggtggtagatgtggaggtgatggagccgcttgggtgagtcccagccta
gccagtgtgtcctcagggaggaagtctccacattccaaatccccatcagagcagcgggag
cggaagtccttggctgatgagaagaagaaagtgaagaacctggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagctgctgaagaggattgggacaggctca
tttggcacggtgtttcatgggcggtggcatggtgatgtggctgtgaaggtgctcaaggta
atgactgcatatcttgctagtttcctccattccctgacactgcccttccctgcctgcagg
aaaactcgacatgtcaacatcttgctgttcatgggcttcatgacccggccaggatttgcc
attattacacaatggtgtgaaggttccagtctctaccaccacctgcatgttgccgacaca
cgctttgacatggtccagcttattgatgtagcccggcagactgcccagggcatggactac
ctccatgccaagaacatcatccaccgagatctcaagtctaataatatcttcttacatgag
gggctcacagtgaagattggtgactttggcctggccacggtgaagacacgatggagtggg
gcacagcccttggagcagccctcaggctcagtgctttggatggcagctgaggtgattcga
atgcaggacccaaacccatacagcttccagtcagatgtctatgcctacggggttgtactc
tatgagctgatgacaagttcactgccttatagccacattggcagtcgtgaccagattatc
tttatggttggccgtggctatctgtccccggacctcagcaaagtttccagcaactgcccc
aaagccatgcggcgcctgctatctgattgtctcaagttcaagagggaagaacggcctctc
ttcccccagatcctggccacgattgagctgcttcagcgatcactccccaagattgagcgg
agtgcctccgaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctactc
agcgcagcccgcccagtaccttag

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