Streptomyces laurentii: SLA_2288
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Entry
SLA_2288 CDS
T05205
Name
(GenBank) folylpolyglutamate synthase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
slau
Streptomyces laurentii
Pathway
slau00790
Folate biosynthesis
slau01100
Metabolic pathways
slau01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
slau00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
SLA_2288
Enzymes [BR:
slau01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
SLA_2288
6.3.2.17 tetrahydrofolate synthase
SLA_2288
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_C
Mur_ligase_M
Motif
Other DBs
NCBI-ProteinID:
BAU83218
UniProt:
A0A169NDN2
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Position
complement(2391192..2392706)
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AA seq
504 aa
AA seq
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MSDSSDPRDQGDDDQFDGIVDEATDRDPDLAVIEAGSRTLRAMTGPPQGDPVPSRPEDPE
VDRALREVENELATRWGETKLEPSVKRIAALMDVLGEPQRAYPSIHITGTNGKTSTARMI
ESLLGAFDLRTGRYTSPHVQTITERISLDGAPIDPERFIETYQDVKPYVEMVDAREEYRL
SFFEVLTGMAYAAFADAPVDVAVVEVGMGGTWDATNVIDASVAVVTPIDLDHTDRLGSTT
GEIAGEKSGVIKQDATVILAQQPVDAAQVLLKKAVEADATVAREGMEFGVTAREVAVGGQ
QLTLRGLGGEYEGVFLPLYGAHQAHNAAVALAAVEAFFGIGAQHARALDIDTVRRAFAQV
ASPGRLEVVRSSPTVVLDAAHNPHGARATAEAVTESFGFSRLIGVVSTSADKDARGLLEA
FEPIFAEIVITSNSNPRATDPDALAALAVEIFGEDRVVVEPRLDDAIEAAITLAEEEGEY
AGGGVLVTGSIFTVGDARLLLKRG
NT seq
1515 nt
NT seq
+upstream
nt +downstream
nt
gtgagtgactcgagcgacccgcgcgaccagggcgacgacgaccagttcgacggcatcgtc
gacgaagcgaccgaccgtgaccccgacctggcggtgatcgaggccggcagccgcacgctg
cgcgcgatgaccggcccgccgcagggcgacccggtgccgtcccggcccgaggaccccgag
gtcgaccgggcattgcgggaggtcgagaacgagctggcgacccgctggggcgagacgaag
ctggagccgtcggtcaagcggatcgcggccctgatggacgtgctgggcgagccgcagcgc
gcgtacccgtcgatccacatcacgggcaccaacggcaagacgtccacggcccgcatgatc
gagtcgctcctcggcgccttcgacctgcgcaccggccgctacacgtcgccgcacgtgcag
accatcacggagcggatcagcctggacggcgccccgatcgacccggagcggttcatcgag
acgtaccaggacgtcaagccgtacgtggagatggtcgacgcccgcgaggagtaccggctg
tcgttcttcgaggtcctcaccggcatggcgtacgcggcgttcgcggacgccccggtggac
gtggccgtcgtcgaggtcggcatgggcggcacctgggacgcgacgaacgtgatcgacgcg
tcggtcgccgtggtcacccccatcgacctggaccacacggaccggctcggttcgacgacg
ggcgagatcgcgggcgagaagtccggtgtcatcaagcaggacgccacggtgatcctcgcc
cagcagccggtcgacgccgcgcaggtgctcctgaagaaggccgtcgaggcggacgccacc
gtggcccgcgagggcatggagttcggcgtcaccgcgcgcgaggtcgcggtcggcggccag
cagctgaccctgcggggtctgggcggcgagtacgagggtgtcttcctgccgctgtacggc
gcgcaccaggcgcacaacgcggcggtggcgctggcggccgtcgaggcgttcttcggcatc
ggcgcgcagcacgcccgcgccctggacatcgacacggtccgccgcgcgttcgcccaggtg
gcgtcgccgggccggctggaggtcgtccgctcgtcgccgacggtcgtcctggacgcggcg
cacaacccgcacggcgcccgcgcgacggccgaggccgtcaccgagtccttcggcttctcc
cggctcatcggcgtggtctccacgagcgccgacaaggacgcccgcggtctcctggaggcc
ttcgagccgatcttcgcggagatcgtgatcacctcgaactccaacccgcgcgccaccgac
ccggacgcgctcgccgcgctcgcggtcgagatcttcggcgaggaccgggtggtggtcgag
ccgcgcctggacgacgccatcgaggccgcgatcacgctcgccgaggaagagggcgagtac
gcgggcggcggcgtcctcgtcaccggttcgatcttcacggtcggcgacgcccggctgctg
ctcaagaggggctga
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