Streptococcus pyogenes MGAS6180 (serotype M28): M28_Spy0730
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Entry
M28_Spy0730 CDS
T00263
Symbol
acoA
Name
(GenBank) pyruvate dehydrogenase E1 component alpha subunit
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
spb
Streptococcus pyogenes MGAS6180 (serotype M28)
Pathway
spb00010
Glycolysis / Gluconeogenesis
spb00020
Citrate cycle (TCA cycle)
spb00620
Pyruvate metabolism
spb00785
Lipoic acid metabolism
spb01100
Metabolic pathways
spb01110
Biosynthesis of secondary metabolites
spb01120
Microbial metabolism in diverse environments
spb01200
Carbon metabolism
spb01210
2-Oxocarboxylic acid metabolism
Module
spb_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
spb00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
M28_Spy0730 (acoA)
00020 Citrate cycle (TCA cycle)
M28_Spy0730 (acoA)
00620 Pyruvate metabolism
M28_Spy0730 (acoA)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
M28_Spy0730 (acoA)
Enzymes [BR:
spb01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
M28_Spy0730 (acoA)
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GFIT
Motif
Pfam:
E1_dh
TPP_enzyme_C
Transketolase_N
DXP_synthase_N
Motif
Other DBs
NCBI-ProteinID:
AAX71843
UniProt:
Q48TW3
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All DBs
Position
751097..752077
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AA seq
326 aa
AA seq
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MEAEMVTVSKEQHLDMFLKMERIREFDSRINKLVRRGFVQGMTHFSVGEEAANVGAVAHL
SYDDIIFSNHRGHGQSIAKDMDLNKMMAELAGKATGVSKGRGGSMHLADFEKGNYGTNGI
VGGGYALAVGAALTQQYKGTNNIAVAFSGDGATNEGSFHESVNMAATWKLPVIFFIINNR
YGISMSINNATNTPHLYTRAEAYGIPGFYCEDGNDVMAVYETMGKAVEHVRGGNGPAIVE
VESYRWFGHSTADAGKYRTKEEVDEWKEKDPMIKYRTYLTSEGIATDDELDAIQAQVKKE
VDDAYEFAQNSPDPELSVAFEDVWVD
NT seq
981 nt
NT seq
+upstream
nt +downstream
nt
atggaggccgaaatggtaacagtttctaaagaacaacatttggatatgttccttaaaatg
gaacgtattcgtgaatttgattcacgtattaataaactcgtccgtcgtggatttgtacaa
ggcatgactcacttctcagttggtgaagaagcagccaatgttggagcggtggctcacttg
tcttacgatgacattattttttcaaatcaccgtggacatggacaatcaatcgctaaagac
atggaccttaataaaatgatggctgagcttgctggtaaagcgactggtgtttctaaaggg
cgtggtggctcaatgcacttggctgattttgaaaaaggaaactatggtaccaatggtatc
gttggtggtggttacgctcttgcagttggtgctgccctcacccaacaatacaaaggaact
aacaatatagctgttgctttctcaggtgatggcgctactaacgaaggatcattccacgag
tctgttaatatggctgcaacatggaaacttcctgttattttcttcatcatcaacaaccgt
tatggaatttcaatgagcatcaataatgcaacaaatacaccacatttatacacacgtgca
gaagcttacggaattcctggtttctactgtgaagatggcaatgacgtgatggctgtctat
gaaacaatgggcaaagccgttgaacatgttcgtggtggaaatggtccagctattgttgag
gtagaatcataccgttggtttggtcactcgactgcagatgctggtaaataccgtactaaa
gaagaagtggatgagtggaaagaaaaagatccaatgatcaaatatcgtacttatctgaca
agcgaaggcattgccactgatgacgaattggatgctattcaagcacaagtcaaaaaagaa
gttgacgatgcttatgaatttgcacaaaacagtccagatccagaactttcagtagccttc
gaagacgtttgggttgactaa
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