Streptococcus pneumoniae D39 (virulent serotype 2): SPD_0183
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Entry
SPD_0183 CDS
T00413
Symbol
folC
Name
(GenBank) folylpolyglutamate synthase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
spd
Streptococcus pneumoniae D39 (virulent serotype 2)
Pathway
spd00790
Folate biosynthesis
spd01100
Metabolic pathways
spd01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
spd00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
SPD_0183 (folC)
Enzymes [BR:
spd01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
SPD_0183 (folC)
6.3.2.17 tetrahydrofolate synthase
SPD_0183 (folC)
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-ProteinID:
ABJ54790
UniProt:
A0A0H2ZQ04
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Position
185813..187069
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AA seq
418 aa
AA seq
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MCMFEVKEWLHSRIGLNFRSGLGRMQQAVDLLGNPEQSYPIIHVTGTNGKGSTIAFMREL
FMGHGKKVATFTSPHIVSINDRICINGQPIADADFIRLADQVKEMEKTLLQTPDQLSFFE
LLTLVAFLYFRGQEVDLVLLEVGIGGLLDTTNVVTGELAVITSIGLDHQETLGDSLEAIA
EQKAGIFKAGKKAVIAKLPPEARLVCQKKAESLAVNLYQAGQDFSVLNGDFSSSLLNLSQ
LNIGLEGVYQQENAALALQTFLLFMGEGKEAVDEQAVRKALEQTHWAGRLERIRPQIYLD
GAHNLPALTRLVEFIKEKEQEGYRPQILFGSLKRKDYQGMLGYLTENLPQVELKMTGFDY
QGSLDETDVTGYHVIPSYREFISSFEERADAQDLLFVTGSLYFISEVRGYLLDREQIN
NT seq
1257 nt
NT seq
+upstream
nt +downstream
nt
atgtgtatgtttgaagtaaaagaatggctccatagtcggattggtttgaattttcgatca
ggtttgggccgaatgcagcaagcggtggatttgttaggaaatcctgagcagtcttaccct
attatccacgtaacagggactaatgggaaaggatctaccattgcttttatgagggaatta
tttatggggcatggcaaaaaagttgcgacctttacctcccctcatatcgtctctatcaat
gaccgaatctgcattaatgggcaacctatagcagacgcagactttatccgtttggctgat
caggtcaaggagatggagaaaacgcttctgcaaactcctgaccagttgtccttttttgaa
ttgctgaccttagttgcttttctttattttagggggcaagaggtggatttggttttatta
gaagtgggaattggtggcttacttgacacgaccaatgtggtaactggagagcttgctgtc
atcacctccattgggcttgaccatcaagaaaccttgggtgatagtctagaagcaattgca
gagcagaaagctggtattttcaaggctggtaagaaggcagtgattgcgaaattgcctcca
gaagctaggcttgtctgtcagaaaaaagccgaatctttagctgttaacctttatcaggca
ggtcaagatttttcagtgctgaatggtgatttttcaagctctttactaaatctttcacag
ctgaacataggcttagaaggagtctatcagcaggagaatgcagccttggcgttgcaaact
tttcttctttttatgggagaaggaaaggaagctgttgatgaacaggctgtaagaaaggcc
ttggaacagacccattgggctggtcgcttggagcgtattcgcccacagatttacttggat
ggtgctcataacctccctgccttgactcgcttggttgagtttatcaaagaaaaagagcag
gaaggctatcgacctcaaatcctctttggatccttgaaacgtaaggattatcaagggatg
ttgggttatctgactgaaaatttacctcaagtggaactcaaaatgaccggctttgactat
caagggtctttggacgagacagatgtaacaggttaccatgtaattccctcttaccgagaa
tttatcagcagtttcgaagaaagggcagacgctcaagacttgctgttcgttacagggtct
ctctattttatctcagaagtacggggctacctgctggaccgtgagcagataaattga
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