Streptococcus pyogenes MGAS10270 (serotype M2): MGAS10270_Spy0684
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Entry
MGAS10270_Spy0684 CDS
T00355
Symbol
folC2
Name
(GenBank) Folylpolyglutamate synthase / Dihydrofolate synthase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
sph
Streptococcus pyogenes MGAS10270 (serotype M2)
Pathway
sph00790
Folate biosynthesis
sph01100
Metabolic pathways
sph01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
sph00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
MGAS10270_Spy0684 (folC2)
Enzymes [BR:
sph01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
MGAS10270_Spy0684 (folC2)
6.3.2.17 tetrahydrofolate synthase
MGAS10270_Spy0684 (folC2)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-ProteinID:
ABF33749
UniProt:
Q1JHI7
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All DBs
Position
complement(662513..663805)
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AA seq
430 aa
AA seq
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MLEGQEIVMTTYDSISWIHTFKANGRKTDLARMAWLLEALGRPQDKFPAIHVVGTNGKGS
VTAYLQHILSTSGYQVGTFTSPFIISFHDRICLNGQPISDLELAQCVSVIRPILTKMSLE
TNWDRPTEFELVTLIMFCYFANLKPVDIAIIEAGIGGKTDATNVFHALAVVCPSISFDHQ
ERLGYSLAEIAHQKAEVIKAKEPVIIGQLEQEASQVFQQVTQKAGSRLYQLGKDFLLNPS
EKTISFQHDNLNLTKLRLKLLGQHQKANACLTIMTAQLLRKSFPKISPKTIQKGIETTTW
PGRSEFIQPNLLLDGAHNPDSIAKLKSLLQEEFPKRPIHILFAGLKRKPLADLLAQLDTF
EVSVTTFDFPEANLLEDYPDKYPQVKDYRDWLQGSVTSDELFVVTGSLYFISEVRQYCLS
NANIFKNIFP
NT seq
1293 nt
NT seq
+upstream
nt +downstream
nt
ttgttagaaggacaagaaatagtaatgactacctatgatagcatttcctggattcatacc
tttaaggctaatggtcgcaagaccgatttggccagaatggcttggttacttgaggcacta
ggccggccacaagacaaattccctgctattcacgttgttggaactaacggcaagggctct
gtgacagcctacttacagcatatcctgtcaacttctggttatcaggtcggaacctttaca
tctccttttatcatctcttttcacgatcggatttgccttaatggccagcccatttcagac
ctagaattggcgcaatgtgtgagcgtgattagacccattctcactaaaatgtcccttgaa
acaaattgggatagacctaccgagtttgagttagtgactctcataatgttttgctacttt
gccaatcttaaacctgttgatattgccattattgaggcagggattggtgggaaaaccgac
gcaaccaatgtttttcatgctctggccgtcgtatgcccttccattagttttgatcaccaa
gaacgtttaggttatagcctagcagaaattgctcaccaaaaagcagaagttatcaaagct
aaagaacccgttattatcggtcaacttgaacaggaggctagtcaagtctttcaacaagtt
acccaaaaagccggttcacgcttatatcaattaggaaaagattttttgctcaatccttca
gaaaagacgatttcctttcaacacgataacttgaatttaaccaaactccgtctcaaacta
ttaggtcaacatcaaaaagcgaatgcctgtttaaccattatgacagctcaattacttaga
aaatcctttcctaaaatatctccaaaaacgattcaaaaaggaattgagacaacaacttgg
cctggccggtccgaatttattcaacctaatcttctattagacggtgcccacaacccagat
tctattgctaaattaaagtctctactgcaagaagaatttcccaaacgtcctattcatatt
ctctttgcaggtctcaaacgtaagcctttagccgacttgctggctcaactagatactttt
gaagtatctgtcacgacttttgatttccctgaagcaaatcttttagaggattatcctgat
aaatacccacaggtaaaagattacagagactggttacaaggttccgtaacatctgatgaa
ctctttgttgttacagggtcactttattttatctccgaggtaaggcaatattgtctgagc
aacgcaaatatctttaaaaacatattcccctaa
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