Streptococcus pyogenes MGAS10750 (serotype M4): MGAS10750_Spy0903
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Entry
MGAS10750_Spy0903 CDS
T00356
Symbol
acoA
Name
(GenBank) Pyruvate dehydrogenase E1 component alpha subunit
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
spi
Streptococcus pyogenes MGAS10750 (serotype M4)
Pathway
spi00010
Glycolysis / Gluconeogenesis
spi00020
Citrate cycle (TCA cycle)
spi00620
Pyruvate metabolism
spi00785
Lipoic acid metabolism
spi01100
Metabolic pathways
spi01110
Biosynthesis of secondary metabolites
spi01120
Microbial metabolism in diverse environments
spi01200
Carbon metabolism
spi01210
2-Oxocarboxylic acid metabolism
Module
spi_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
spi00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
MGAS10750_Spy0903 (acoA)
00020 Citrate cycle (TCA cycle)
MGAS10750_Spy0903 (acoA)
00620 Pyruvate metabolism
MGAS10750_Spy0903 (acoA)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
MGAS10750_Spy0903 (acoA)
Enzymes [BR:
spi01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
MGAS10750_Spy0903 (acoA)
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Gene cluster
GFIT
Motif
Pfam:
E1_dh
TPP_enzyme_C
Transketolase_N
DXP_synthase_N
Motif
Other DBs
NCBI-ProteinID:
ABF37853
UniProt:
Q1J6Y0
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All DBs
Position
855521..856501
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AA seq
326 aa
AA seq
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MEAEMVTVSKEQHLDMFLKMERIREFDSRINKLVRRGFVQGMTHFSVGEEAANVGAVAHL
SYDDIIFSNHRGHGQSIAKDMDLNKMMAELAGKATGVSKGRGGSMHLADFEKGNYGTNGI
VGGGYALAVGAALTQQYKGTNNIAVAFSGDGATNEGSFHESVNMAATWKLPVIFFIINNR
YGISMSINNATNTPHLYTRAEAYGIPGFYCEDGNDVMAVYETMGKAVEHVRGGNGPAIVE
VESYRWFGHSTADAGKYRTKEEVDEWKEKDPMIKYRTYLTSEGIATDDELDAIQAQVKKE
VDDAYEFAQNSPDPELSVAFEDVWVD
NT seq
981 nt
NT seq
+upstream
nt +downstream
nt
atggaggccgaaatggtaacagtttctaaagaacaacatttggatatgttccttaaaatg
gaacgtattcgtgaatttgattcacgtattaataaactcgtccgtcgtggatttgtacaa
gggatgactcacttctcagttggtgaagaagcagccaatgttggagcggtggctcacttg
tcttacgatgacattattttttcaaatcaccgtggacatggacaatcaatcgctaaagac
atggaccttaataaaatgatggctgagcttgctggtaaagcaactggtgtttctaaaggg
cgtggtggctcaatgcacttggctgattttgaaaaaggaaactatggtaccaatggtatc
gttggtggtggttacgctcttgcagttggtgctgccctcacccaacaatacaaaggaact
aacaatatagctgttgctttctcaggtgatggcgctactaacgaaggatcattccacgag
tctgttaatatggctgcaacatggaaacttcctgttattttcttcatcatcaacaaccgt
tatggaatttcaatgagcatcaataatgcaacaaatacaccacacttatacacacgtgca
gaagcttacggaattcctggtttctactgtgaagatggcaatgacgtgatggctgtctat
gaaacaatgggcaaagctgttgagcatgttcgtggtggaaatggcccagctattgttgag
gtagaatcataccgttggtttggtcactcgactgcagatgctggtaaataccgtactaaa
gaagaagtagatgagtggaaagaaaaagatccaatgatcaaatatcgtacttatctgaca
agcgaaggcattgccactgatgacgaattggatgctattcaagcacaagtcaaaaaagaa
gttgacgatgcttatgaatttgcacaaaacagtccagatccagaactttcagtagccttc
gaggacgtttgggttgactaa
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