Streptococcus pyogenes MGAS10750 (serotype M4): MGAS10750_Spy0971
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Entry
MGAS10750_Spy0971 CDS
T00356
Symbol
folC1
Name
(GenBank) Folylpolyglutamate synthase / Dihydrofolate synthase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
spi
Streptococcus pyogenes MGAS10750 (serotype M4)
Pathway
spi00790
Folate biosynthesis
spi01100
Metabolic pathways
spi01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
spi00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
MGAS10750_Spy0971 (folC1)
Enzymes [BR:
spi01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
MGAS10750_Spy0971 (folC1)
6.3.2.17 tetrahydrofolate synthase
MGAS10750_Spy0971 (folC1)
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Gene cluster
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-ProteinID:
ABF37921
UniProt:
Q1J6R2
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All DBs
Position
920930..922306
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AA seq
458 aa
AA seq
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MFGEDKKKKGTTLGYLLSLFFIYGILKIDVRYEMTYEETLEWIHDHLVFGIKPGLKRMLW
VLGQLGNPQKNVKGVHIVGTNGKGSTVNHLQHIFTTAGYEVGTFTSPYIMDFKERISING
RMISEKDLVIAANRIRPLTERLVRETDFGEVTEFEVITLIMFLYFGDMHPVDIAIIEAGL
GGLYDSTNVFQAMVVVCPSIGLDHQAILGETYADIAAQKAGVLEGGETLVFAVENPSARE
VFLTKAEQVGASIWEWQEQFQMAENASGYRFTSPLGVISDIHIAMPGHHQVSNAALAIMT
CLTLKDRYPRLTSDHIREGLANSLWLGRTELLAPNLMIDGAHNNESVAALVAVLKNNYND
KKLHILFGAIDTKPIADMLVALEQIGDLQVTSFHYPNAYPLEKYPERFGRVADFKDFLAL
RKHAKADDFFVITGSLYFISEIRRYWKKHIEKSVLLTH
NT seq
1377 nt
NT seq
+upstream
nt +downstream
nt
gtgtttggtgaggataagaaaaaaaagggtactactctaggttatctgctgtcacttttt
tttatatatggtatactaaagatagatgtgaggtatgaaatgacttatgaagagactcta
gaatggattcatgatcacttagttttcggcatcaagccaggcttaaaacgtatgctttgg
gttcttggacagttaggaaatccccaaaaaaatgtcaagggagtgcatatcgttggaact
aacggaaaaggttccacggtcaatcatttacaacacatctttacgacagctggttatgaa
gtggggacctttacctctccttatattatggatttcaaagaacgtattagcataaatggt
cgaatgatttcagaaaaagatttggttattgctgctaatcgtattcgtcctttgacagag
cgtctagttcgagagactgattttggagaggtaactgaatttgaagtgattactttgatc
atgttcctctattttggtgatatgcatcctgtagatattgctattattgaagcaggcctt
ggcggtctttatgattcgaccaatgtttttcaagcaatggttgtggtctgtccctcaatt
ggtttagatcaccaagctattttgggagagacttacgctgatattgccgcccaaaaagct
ggtgttttagaagggggcgagacccttgtttttgccgttgaaaacccgtcagctcgagag
gtttttttaacaaaagctgagcaggttggtgcttcaatctgggaatggcaagagcagttt
caaatggctgagaacgcatctggctatcgttttactagtcctttaggagttatttcagat
attcacatcgctatgccaggacaccaccaagtgtctaatgcagctttagctattatgact
tgcttaaccttgaaagaccgctatcctaggctaacttcagatcatataagggaaggtcta
gcaaatagtttgtggctaggccgtaccgaattattagcaccaaatctaatgattgatggg
gctcataacaatgaaagcgttgctgctttggtagccgtcttaaaaaataactacaatgat
aaaaagcttcatattttgtttggtgcgatcgacaccaagcctattgcagatatgttggtt
gctcttgagcaaataggtgacttgcaggttactagctttcattaccctaacgcctatcca
ttggaaaaatacccagaacgttttggtagggttgctgatttcaaagatttcttggccctg
cgtaagcatgctaaagcagatgactttttcgtgattacagggtcactatattttatttca
gaaattagacggtattggaaaaaacatattgaaaaaagcgttcttttaacccattaa
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