Streptococcus pyogenes MGAS8232 (serotype M18): spyM18_1058
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Entry
spyM18_1058 CDS
T00079
Symbol
folC
Name
(GenBank) putative folyl-polyglutamate synthetase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
spm
Streptococcus pyogenes MGAS8232 (serotype M18)
Pathway
spm00790
Folate biosynthesis
spm01100
Metabolic pathways
spm01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
spm00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
spyM18_1058 (folC)
Enzymes [BR:
spm01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
spyM18_1058 (folC)
6.3.2.17 tetrahydrofolate synthase
spyM18_1058 (folC)
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Gene cluster
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-ProteinID:
AAL97682
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Position
876577..877854
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AA seq
425 aa
AA seq
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MTYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHIVGTNGKGSTVNHLQHI
FTTAGYEVGTFTSPYIMDFKERISINGRMISEKDLVIAANRIRPLTERLVQETDFGEVTE
FEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAMVVVCPSIGLDHQAILGETYA
DIAAQKAGVLEGGETLVFAVEKPSAREVFLTKAEQVGASIWEWQEQFQMAENASGYRFTS
PLGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYPRLTSDHIREGLANSLWLGRTELLA
PNLMIDGAHNNESVAALVAVLKNNYNDKKLHILFGAIDTKPIADMLVALEQIGDLQVTSF
HYPNAYPLEKYPERFGRVADFKDFLALRKHAKADDFFVITGSLYFISEIRQYWEKHIEKS
VLLTH
NT seq
1278 nt
NT seq
+upstream
nt +downstream
nt
atgacttatgaagagactctagaatggattcatgatcacttagttttcggcatcaagcca
ggcttaaaacgtatgctttgggttcttggacagttaggaaatccccaaaaaaatgtcaag
ggagtgcatatcgttggaactaacggaaaaggttccacggttaatcatttacaacacatc
tttacgacagctggttatgaagtggggacctttacctctccttatattatggatttcaaa
gaacgtattagcataaatggtcgaatgatttcagaaaaagatttggttattgctgctaat
cgtattcgtcctttgacagagcgtctagttcaagagactgattttggagaggtaactgaa
tttgaagtgattactttgatcatgttcctctattttggagacatgcatcctgtagatatt
gctattattgaagcaggccttggcggtctttatgattcgaccaatgtttttcaagcaatg
gttgtggtctgtccctcaattggtttagatcaccaagctattttgggagagacttacgct
gatattgccgcccaaaaagctggtgttttagaagggggcgagacccttgtttttgccgtt
gaaaaaccgtcagctcgagaggtttttttaacaaaagctgagcaggttggtgcttcaatc
tgggaatggcaagagcagtttcaaatggctgagaacgcatctggctatcgttttactagt
cctttaggagttatttcagatattcacatcgctatgccaggacaccaccaagtgtctaat
gcagctttagctattatgacttgcttaaccttgaaagaccgctatcctaggctaacttca
gatcatataagggaaggtctagcaaatagtttgtggctaggccgtaccgaattattagca
ccaaatctaatgattgatggggctcataacaatgaaagcgttgctgctttggtagccgtc
ttaaaaaataactacaatgataaaaagcttcatattttgtttggtgcgatcgacaccaag
cctattgcagatatgttggttgctcttgagcaaataggtgacttgcaggttactagcttt
cattaccctaacgcctatccattggaaaaatacccagaacgttttggtagggttgctgat
ttcaaagatttcttggccttgcgtaagcatgctaaagcagatgactttttcgtgattaca
gggtcactatattttatttcagaaattagacagtattgggaaaaacatattgaaaaaagc
gttcttttaacccattaa
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