Streptococcus pneumoniae TIGR4 (virulent serotype 4): SP_0197
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Entry
SP_0197 CDS
T00057
Name
(GenBank) putative dihydrofolate synthetase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
spn
Streptococcus pneumoniae TIGR4 (virulent serotype 4)
Pathway
spn00790
Folate biosynthesis
spn01100
Metabolic pathways
spn01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
spn00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
SP_0197
Enzymes [BR:
spn01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
SP_0197
6.3.2.17 tetrahydrofolate synthase
SP_0197
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Gene cluster
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-ProteinID:
AAK74377
UniProt:
A0A0H2UN62
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Position
183283..184533
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AA seq
416 aa
AA seq
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MFEVEEWLHSRIGLNFRSGLGRMQQAVDLLGNPEQSYPIIHVTGTNGKGSTIAFMRELFM
GHGKKVATFTSPHIVSINDRICINGQPIADADFIRLTDQVKEMEKTLLQTPAQLSFFELL
TLVAFLYFREQEVDLVLLEVGIGGLLDTTNVVTGEFAVITSIGLDHQETLGDSLEAIAEQ
KAGIFKAGKKAVIAKLPPEARLACQKKAESLAVNLYQAGQDFLMLNGDFSSSLLNLSQLN
IGLEGVYQQENAALALQTFLLFMRERKEAVDEQAVRKALEQTHWAGRLERIRPQIYLDGA
HNLPALTRLAEFIKEKEQEGYRPQILFGSLKRKDYQGMLGYLTEKLPQVELKVTGFDYQG
ALDERDVTGYDIVSSYREFISDFEERADAQDLLFVTGSLYFISEVRGYLLDREQIN
NT seq
1251 nt
NT seq
+upstream
nt +downstream
nt
atgtttgaagtagaagaatggctccatagtcggattggtttgaattttcgatcaggtttg
ggtcgaatgcagcaagcggtggatttgttaggaaatcctgagcagtcttaccctattatc
cacgtaacagggactaatgggaaaggatctaccattgcttttatgagggaattatttatg
gggcatggcaaaaaagttgcgacctttacctcccctcatatcgtctctatcaatgaccga
atctgcattaatgggcagcctatagcagacgcagactttatccgtttgactgatcaggtc
aaggagatggagaaaacgcttctgcaaactcctgcccagttgtccttttttgaattgctg
accttggttgcttttctttattttagggagcaggaggtggatttggttttattagaagtg
ggaattggtggcttacttgacacgaccaatgtggtaactggagagtttgctgtcatcacc
tccattgggcttgaccatcaagaaaccttgggtgatagtctagaagcaattgcagagcag
aaagctggtattttcaaggctggtaagaaggcagtgattgcgaaattgcctccagaagct
aggcttgcctgtcagaaaaaagccgaatctttagctgttaacctttatcaggcaggtcaa
gattttttaatgctgaatggtgatttttcaagctctttactaaatctttcacagctgaac
ataggcttagaaggagtctatcagcaggagaatgcagccttggcgttgcaaacttttctt
ctttttatgagagaaagaaaggaagctgttgatgaacaggctgtaagaaaggccttggaa
cagacccattgggctggtcgcttggagcgtattcgcccacagatttatttggatggtgct
cataacctccctgccttgactcgcttggctgagtttatcaaagaaaaagagcaggaaggc
tatcgacctcaaatcctctttggatccttgaaacgtaaggattatcaagggatgttgggt
tatctgactgaaaaattgcctcaggtggaactcaaggtgaccggctttgactatcagggg
gctttggacgaaagggatgtgacaggttacgatatagtttcttcttaccgagaatttatc
agcgattttgaagaaagggcagacgctcaagacttgctgttcgttacagggtctctctat
tttatctcagaagtacggggctacctgctggaccgtgagcagataaattga
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