Streptococcus pneumoniae TIGR4 (virulent serotype 4): SP_0290
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Entry
SP_0290 CDS
T00057
Symbol
folC
Name
(GenBank) dihydrofolate synthetase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
spn
Streptococcus pneumoniae TIGR4 (virulent serotype 4)
Pathway
spn00790
Folate biosynthesis
spn01100
Metabolic pathways
spn01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
spn00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
SP_0290 (folC)
Enzymes [BR:
spn01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
SP_0290 (folC)
6.3.2.17 tetrahydrofolate synthase
SP_0290 (folC)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_C
Mur_ligase_M
NuiA
Motif
Other DBs
NCBI-ProteinID:
AAK74468
UniProt:
A0A0H2UNA3
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Position
268517..269839
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AA seq
440 aa
AA seq
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MKEIENNQWIANYRTDQPHFGLERMVELLALRGNPHLKLKVLHIGGTNGKGSTIAFLKKM
LEKLGLRVGVFSSPYLIHYTDQISINGESISEARLEALMADYQSLLEGEAVANLQGTTEF
EIITALAYDYFASEQVDVAIMEVGMGGLLDSTNVCQPILTGITTIGLDHVALLGDTLEVI
AEQKAGIIKQGMPLVTGRIAPEALAVIDRIAEGKDAPRLAYGTDYQVRHQESVVTGEVFD
YTSAVRQGRFQTSLLGLYQIENAGMAIALLDTFCQEDGRELASNDFLGQALEETSWPGRL
EIVSRDPLMILDGAHNPHAIKALLVTLQERFADYHKEILFTCIKTKALEDMLDLLGAMPV
TELTLTHFADSRATDENVLKEAAKSRNLSYQDWHDFLEQNLTDKKEEKQTVRIVTGSLYF
LSQVRAYLMERKNENGYTKD
NT seq
1323 nt
NT seq
+upstream
nt +downstream
nt
atgaaagaaattgaaaacaatcagtggattgctaactaccggacggatcaaccgcatttt
ggcttggaacgaatggtggaactgttagctttgcgtggcaatccccatctcaaactcaag
gtcctccatatcggagggactaacggcaagggctcgactattgcttttttgaaaaagatg
ctagaaaagctagggttgagagttggcgtgtttagctcgccctatctcattcattacaca
gaccagattagcatcaatggggaatcgatctcagaagcgaggctagaagctctcatggca
gactatcagtctttgctggagggagaagcggtcgccaatttacagggcacaaccgagttt
gagattatcacagccctggcctatgactactttgcctcagagcaagtagatgtggccatc
atggaagttggcatgggtggacttttggatagtaccaatgtctgtcagcccattttgaca
ggaattacaactattggcttggatcatgtggctctacttggtgacaccttggaggtcata
gcagagcagaaggcaggtattatcaaacaagggatgcccttggtaacagggcgtattgct
ccagaagccttggctgtgattgaccgcattgcggaagggaaagatgcgccgagacttgcc
tacgggacagattatcaggttcgtcatcaagaaagtgtggtgacaggggaagtctttgac
tatacaagtgctgtcagacaaggtcgcttccagactagcctgcttggtttgtaccaaata
gagaatgctgggatggccatagctttacttgatactttttgtcaagaagatggtcgagag
ctagcaagcaatgattttcttggtcaagccttggaagaaacaagttggccagggcgtttg
gaaatcgtgtcaagagatcccttgatgattttggatggagcccacaatccccatgctatc
aaggccttgttggtaaccttgcaagaacgttttgcggattatcataaggaaatcctcttc
acttgtatcaaaaccaaggccttggaggatatgttggacttgctgggagccatgccagtt
accgagcttactctaacacattttgcggatagtcgggcgacggatgaaaacgtgctgaaa
gaggcagctaagtctagaaatctcagctaccaagattggcatgattttctagagcagaat
ttgacagataaaaaagaagagaaacaaacagttaggattgtcacaggttccttgtatttc
ttgagccaagtgagggcctatctgatggagaggaagaacgagaatggatacacaaaagat
tga
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