Streptococcus pyogenes M1 476 (serotype M1): M1GAS476_0814
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Entry
M1GAS476_0814 CDS
T02499
Symbol
acoA
Name
(GenBank) pyruvate dehydrogenase E1 component subunit alpha
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
spym
Streptococcus pyogenes M1 476 (serotype M1)
Pathway
spym00010
Glycolysis / Gluconeogenesis
spym00020
Citrate cycle (TCA cycle)
spym00620
Pyruvate metabolism
spym00785
Lipoic acid metabolism
spym01100
Metabolic pathways
spym01110
Biosynthesis of secondary metabolites
spym01120
Microbial metabolism in diverse environments
spym01200
Carbon metabolism
spym01210
2-Oxocarboxylic acid metabolism
Module
spym_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
spym00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
M1GAS476_0814 (acoA)
00020 Citrate cycle (TCA cycle)
M1GAS476_0814 (acoA)
00620 Pyruvate metabolism
M1GAS476_0814 (acoA)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
M1GAS476_0814 (acoA)
Enzymes [BR:
spym01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
M1GAS476_0814 (acoA)
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Motif
Pfam:
E1_dh
TPP_enzyme_C
Transketolase_N
DXP_synthase_N
Motif
Other DBs
NCBI-ProteinID:
BAM30144
UniProt:
J7M3A9
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All DBs
Position
1:771912..772892
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AA seq
326 aa
AA seq
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MEAEMVTVSKEQHLDMFLKMERIREFDSRINKLVRRGFVQGMTHFSVGEEAANVGAVAHL
SYDDIIFSNHRGHGQSIAKDMDLNKMMAELAGKATGVSKGRGGSMHLADFEKGNYGTNGI
VGGGYALAVGAALTQQYKGTNNIAVAFSGDGATNEGSFHESVNMAATWKLPVIFFIINNR
YGISMSINNATNTPHLYTRAEAYGVPGFYCEDGNDVMAVYETMGKAVEHVRGGNGPAIVE
VESYRWFGHSTADAGKYRTKEEVDEWKEKDPMIKYRTYLTSEGIATDDELDAIQAQVKKE
VDDAYEFAQNSPDPELSVAFEDVWVD
NT seq
981 nt
NT seq
+upstream
nt +downstream
nt
atggaggccgaaatggtaacagtttctaaagaacaacatttagatatgttccttaaaatg
gaacgtattcgtgaatttgattcacgtattaataaactcgtccgtcgtggatttgtacaa
gggatgactcacttctcagttggtgaagaagcagccaatgttggagcggtggctcacttg
tcttacgatgacattattttttcaaatcaccgtggacatggacaatcaatcgctaaagac
atggaccttaataaaatgatggctgagcttgctggtaaagcaactggtgtgtctaaaggg
cgtggtggctcaatgcacttggctgattttgaaaaaggaaactatggtactaatggtatc
gttggtggtggttacgctcttgcagttggtgctgccctcactcaacaatacaaaggaact
aacaatatagctgttgctttctcaggtgatggcgctactaacgaaggatcattccacgag
tctgttaatatggctgcaacatggaaacttcctgttattttcttcatcatcaacaaccgt
tatggaatttcaatgagcatcaataatgcaacaaatacaccacacttatacacacgtgca
gaagcttacggagttcctggtttctactgtgaagatggcaatgacgtgatggctgtctat
gaaacaatgggcaaagccgttgaacatgttcgtggtggaaatggtccagctattgttgag
gtagaatcataccgttggtttggtcactcgactgcagatgctggtaaataccgtactaaa
gaagaagtggatgagtggaaagaaaaagatccaatgatcaaatatcgtacttatctgaca
agcgaaggcattgccactgatgacgaattggatgctattcaagcacaagtcaaaaaagaa
gttgacgatgcttatgaatttgcacaaaacagtccagatccagaactttcagtagccttc
gaagacgtttgggttgactaa
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