Theropithecus gelada (gelada): 112606566
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Entry
112606566 CDS
T08041
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase isoform X1
KO
K00501
tyrosine 3-monooxygenase [EC:
1.14.16.2
]
Organism
tge
Theropithecus gelada (gelada)
Pathway
tge00350
Tyrosine metabolism
tge00790
Folate biosynthesis
tge01100
Metabolic pathways
tge04728
Dopaminergic synapse
tge04917
Prolactin signaling pathway
tge05012
Parkinson disease
tge05030
Cocaine addiction
tge05031
Amphetamine addiction
tge05034
Alcoholism
Module
tge_M00042
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:
tge00001
]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
112606566 (TH)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
112606566 (TH)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
112606566 (TH)
09156 Nervous system
04728 Dopaminergic synapse
112606566 (TH)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
112606566 (TH)
09165 Substance dependence
05030 Cocaine addiction
112606566 (TH)
05031 Amphetamine addiction
112606566 (TH)
05034 Alcoholism
112606566 (TH)
Enzymes [BR:
tge01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
112606566 (TH)
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Gene cluster
GFIT
Motif
Pfam:
Biopterin_H
TH_ACT
TOH_N
LTP_2
Motif
Other DBs
NCBI-GeneID:
112606566
NCBI-ProteinID:
XP_025212965
Ensembl:
ENSTGEG00000026784
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Position
14:complement(2435232..2443647)
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AA seq
529 aa
AA seq
DB search
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQVGGPRPSLTGSLWPGTAALAASYTPA
PRSPRFIGRRQSLIEDARKEREAAVAAAAAAAPSEPGDPLEAVAFEEKEGKAVLNLLFSP
RATKPSALSRAVKVFETFEAKIHHLETRPTQRLRAGGPHLEYFVRLEVPRGDLAALLSGV
RQVSEDVRSPAEPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAE
IAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDN
IPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDC
CHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAY
GAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYA
SRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
NT seq
1590 nt
NT seq
+upstream
nt +downstream
nt
atgcccacccccgacgccaccacaccacaggccaagggcttccgcagggccgtgtctgag
ctggatgccaagcaggcagaggccatcatggtaagagggcaggtagggggacccaggccc
agcctcacgggctctctgtggcctggaactgcagccctagctgcatcctacacccccgcc
ccaaggtccccgcggttcattgggcgacggcagagcctcatcgaggacgcccgcaaggag
cgggaggcggcggtggcagcagcagctgctgcggccccctcggagcccggggaccccctg
gaggccgtggcctttgaggaaaaggaggggaaggccgtgctaaacctgctcttctccccg
agggccaccaagccctcagcgctgtcccgagctgtgaaggtatttgagacgtttgaagcc
aaaatccaccacctagagacccggcccacccagaggctgcgagctgggggcccccacctg
gagtactttgtgcgtctcgaggtgccccgaggggacctggccgccctgctcagtggtgtg
cgccaggtgtcagaggacgtgcgcagccccgcggagcccaaggtcccctggttcccaaga
aaagtgtcagagctggacaaatgtcatcacctggtcaccaagtttgaccctgacctggac
ttggaccacccgggcttctcggaccaggtgtaccgccagcgcaggaagctgattgctgag
atcgccttccagtacaggcacggcgacccgattccccgtgtggagtacaccgcggaggag
attgccacctggaaggaggtctacaccacgctgaagggcctctacgccacgcacgcctgc
ggggagcacctggaggcctttgctctgctggagcgcttcagcggctaccgcgaagacaac
atcccccagctggaggatgtctcccgcttcctgaaggagcgcacgggcttccagctgcgg
cctgtggctggcctgctgtccgcccgggacttcctggccagcctggccttccgcgtgttc
cagtgcacccagtacatccggcacgcgtcctcgcccatgcactcccctgagccggactgc
tgccacgagctgctggggcacgtgcccatgctggccgaccgcaccttcgcgcagttctcc
caggacatcggcctggcatccctgggggcttcggatgaggaaattgagaagctgtccacg
ctgtactggttcaccgtggagtttgggctgtgcaaacagaacggggaggtgaaggcctat
ggcgccgggctgctgtcctcctatggggagctcctgcactgcctgtctgaggagcccgag
attcgagccttcgaccctgaagcagcggccgtgcagccctaccaagaccagacgtaccag
tcagtctactttgtgtctgagagcttcagcgacgccaaggacaagctcaggagctatgcc
tcacgcatccagcgccccttctccgtgaagttcgacccatacaccctggccatcgacgtg
ctggacagcccccaggccgtgcggcgctccctggagggtgtccaggatgagctggacacc
ctggcccatgcgctgagtgccattggctag
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