KEGG   Talpa occidentalis (Iberian mole): 119240577
Entry
119240577         CDS       T07495                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
tod  Talpa occidentalis (Iberian mole)
Pathway
tod01521  EGFR tyrosine kinase inhibitor resistance
tod01522  Endocrine resistance
tod04010  MAPK signaling pathway
tod04012  ErbB signaling pathway
tod04014  Ras signaling pathway
tod04015  Rap1 signaling pathway
tod04022  cGMP-PKG signaling pathway
tod04024  cAMP signaling pathway
tod04066  HIF-1 signaling pathway
tod04068  FoxO signaling pathway
tod04071  Sphingolipid signaling pathway
tod04072  Phospholipase D signaling pathway
tod04140  Autophagy - animal
tod04148  Efferocytosis
tod04150  mTOR signaling pathway
tod04151  PI3K-Akt signaling pathway
tod04210  Apoptosis
tod04218  Cellular senescence
tod04270  Vascular smooth muscle contraction
tod04370  VEGF signaling pathway
tod04371  Apelin signaling pathway
tod04540  Gap junction
tod04550  Signaling pathways regulating pluripotency of stem cells
tod04613  Neutrophil extracellular trap formation
tod04620  Toll-like receptor signaling pathway
tod04650  Natural killer cell mediated cytotoxicity
tod04660  T cell receptor signaling pathway
tod04662  B cell receptor signaling pathway
tod04664  Fc epsilon RI signaling pathway
tod04720  Long-term potentiation
tod04722  Neurotrophin signaling pathway
tod04730  Long-term depression
tod04810  Regulation of actin cytoskeleton
tod04910  Insulin signaling pathway
tod04912  GnRH signaling pathway
tod04915  Estrogen signaling pathway
tod04916  Melanogenesis
tod04917  Prolactin signaling pathway
tod04919  Thyroid hormone signaling pathway
tod04921  Oxytocin signaling pathway
tod04926  Relaxin signaling pathway
tod04929  GnRH secretion
tod04934  Cushing syndrome
tod04935  Growth hormone synthesis, secretion and action
tod05010  Alzheimer disease
tod05022  Pathways of neurodegeneration - multiple diseases
tod05132  Salmonella infection
tod05135  Yersinia infection
tod05160  Hepatitis C
tod05161  Hepatitis B
tod05163  Human cytomegalovirus infection
tod05164  Influenza A
tod05165  Human papillomavirus infection
tod05166  Human T-cell leukemia virus 1 infection
tod05167  Kaposi sarcoma-associated herpesvirus infection
tod05170  Human immunodeficiency virus 1 infection
tod05200  Pathways in cancer
tod05205  Proteoglycans in cancer
tod05206  MicroRNAs in cancer
tod05207  Chemical carcinogenesis - receptor activation
tod05208  Chemical carcinogenesis - reactive oxygen species
tod05210  Colorectal cancer
tod05211  Renal cell carcinoma
tod05213  Endometrial cancer
tod05214  Glioma
tod05215  Prostate cancer
tod05216  Thyroid cancer
tod05218  Melanoma
tod05219  Bladder cancer
tod05220  Chronic myeloid leukemia
tod05221  Acute myeloid leukemia
tod05223  Non-small cell lung cancer
tod05224  Breast cancer
tod05225  Hepatocellular carcinoma
tod05226  Gastric cancer
tod05230  Central carbon metabolism in cancer
tod05231  Choline metabolism in cancer
tod05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:tod00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    119240577 (MAP2K2)
   04012 ErbB signaling pathway
    119240577 (MAP2K2)
   04014 Ras signaling pathway
    119240577 (MAP2K2)
   04015 Rap1 signaling pathway
    119240577 (MAP2K2)
   04370 VEGF signaling pathway
    119240577 (MAP2K2)
   04371 Apelin signaling pathway
    119240577 (MAP2K2)
   04066 HIF-1 signaling pathway
    119240577 (MAP2K2)
   04068 FoxO signaling pathway
    119240577 (MAP2K2)
   04072 Phospholipase D signaling pathway
    119240577 (MAP2K2)
   04071 Sphingolipid signaling pathway
    119240577 (MAP2K2)
   04024 cAMP signaling pathway
    119240577 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    119240577 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    119240577 (MAP2K2)
   04150 mTOR signaling pathway
    119240577 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    119240577 (MAP2K2)
   04148 Efferocytosis
    119240577 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    119240577 (MAP2K2)
   04218 Cellular senescence
    119240577 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    119240577 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    119240577 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119240577 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    119240577 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    119240577 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    119240577 (MAP2K2)
   04660 T cell receptor signaling pathway
    119240577 (MAP2K2)
   04662 B cell receptor signaling pathway
    119240577 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    119240577 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119240577 (MAP2K2)
   04929 GnRH secretion
    119240577 (MAP2K2)
   04912 GnRH signaling pathway
    119240577 (MAP2K2)
   04915 Estrogen signaling pathway
    119240577 (MAP2K2)
   04917 Prolactin signaling pathway
    119240577 (MAP2K2)
   04921 Oxytocin signaling pathway
    119240577 (MAP2K2)
   04926 Relaxin signaling pathway
    119240577 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    119240577 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    119240577 (MAP2K2)
   04916 Melanogenesis
    119240577 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    119240577 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    119240577 (MAP2K2)
   04730 Long-term depression
    119240577 (MAP2K2)
   04722 Neurotrophin signaling pathway
    119240577 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119240577 (MAP2K2)
   05206 MicroRNAs in cancer
    119240577 (MAP2K2)
   05205 Proteoglycans in cancer
    119240577 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    119240577 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    119240577 (MAP2K2)
   05230 Central carbon metabolism in cancer
    119240577 (MAP2K2)
   05231 Choline metabolism in cancer
    119240577 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119240577 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119240577 (MAP2K2)
   05225 Hepatocellular carcinoma
    119240577 (MAP2K2)
   05226 Gastric cancer
    119240577 (MAP2K2)
   05214 Glioma
    119240577 (MAP2K2)
   05216 Thyroid cancer
    119240577 (MAP2K2)
   05221 Acute myeloid leukemia
    119240577 (MAP2K2)
   05220 Chronic myeloid leukemia
    119240577 (MAP2K2)
   05218 Melanoma
    119240577 (MAP2K2)
   05211 Renal cell carcinoma
    119240577 (MAP2K2)
   05219 Bladder cancer
    119240577 (MAP2K2)
   05215 Prostate cancer
    119240577 (MAP2K2)
   05213 Endometrial cancer
    119240577 (MAP2K2)
   05224 Breast cancer
    119240577 (MAP2K2)
   05223 Non-small cell lung cancer
    119240577 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119240577 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    119240577 (MAP2K2)
   05161 Hepatitis B
    119240577 (MAP2K2)
   05160 Hepatitis C
    119240577 (MAP2K2)
   05164 Influenza A
    119240577 (MAP2K2)
   05163 Human cytomegalovirus infection
    119240577 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119240577 (MAP2K2)
   05165 Human papillomavirus infection
    119240577 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    119240577 (MAP2K2)
   05135 Yersinia infection
    119240577 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119240577 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    119240577 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    119240577 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119240577 (MAP2K2)
   01522 Endocrine resistance
    119240577 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tod01001]
    119240577 (MAP2K2)
Enzymes [BR:tod01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     119240577 (MAP2K2)
Protein kinases [BR:tod01001]
 Serine/threonine kinases: STE group
  STE7 family
   119240577 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 CAMSAP_CC1 Kdo APH
Other DBs
NCBI-GeneID: 119240577
NCBI-ProteinID: XP_037360980
LinkDB
Position
Unknown
AA seq 400 aa
MLARRKPVLPALTINPAIAEGPSPTSDGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPVVDGVEGEPHSVSPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRIAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccccaccagcgacggcgcttccgaagcaaacttggtggacctccagaagaag
ctagaggagctagagcttgacgaacagcagaagaagcgactggaagccttcctcacccag
aaggccaaggtcggagagctcaaggatgatgactttgaaaggatctcggagctgggagcc
gggaatggcggagtggtcaccaaggtccagcacagaccttcgggccttatcatggcaaga
aagctgatccacttggagatcaagccggccatacggaaccagatcatccgagagctgcag
gtgctgcacgagtgcaactctccgtacatagtgggcttctatggggccttctacagtgac
ggcgagatcagcatctgcatggagcacatggatggaggttctctggaccaagtgttgaaa
gaagccaagagaattcccgaagagattttgggcaaagtcagcattgcggtcctccgaggc
ttggcctacctccgagaaaagcaccagatcatgcaccgagacgtgaagccgtccaacatc
ctcgtcaactccagaggggagatcaagctctgcgatttcggggtcagtgggcagctcatt
gactccatggccaactccttcgtgggaactcggtcctacatgtcgccggagcggttgcaa
ggcacccactactcagtgcagtccgacatctggagcatgggcctgtccctggtggagctg
tccatcggaaggtaccccatccccccaccggacgccaaggagctggaggccatatttggc
cggcccgtggtggatggggtggaaggagagcctcacagtgtctcgccgcggccgaggccc
cctggacgccccatcagcggtcacggcatggacagccggccggctatggctatcttcgag
ctgctggactatattgtgaatgagcctcctcccaagctgcccaatggcgttttcacccag
gacttccaggagtttgtaaataaatgcctaattaagaacccagcagagcgagcggatctg
aagatgctcatgaaccacaccttcatcaaacggtctgaggtggaagaggtggatttcgct
ggctggttgtgtaaaaccctgcggttgaaccagcccagcacacccacgcgcatcgccgtg
tga

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