Talpa occidentalis (Iberian mole): 119249321
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Entry
119249321 CDS
T07495
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase
KO
K04456
RAC serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
tod
Talpa occidentalis (Iberian mole)
Pathway
tod01521
EGFR tyrosine kinase inhibitor resistance
tod01522
Endocrine resistance
tod01524
Platinum drug resistance
tod04010
MAPK signaling pathway
tod04012
ErbB signaling pathway
tod04014
Ras signaling pathway
tod04015
Rap1 signaling pathway
tod04022
cGMP-PKG signaling pathway
tod04024
cAMP signaling pathway
tod04062
Chemokine signaling pathway
tod04066
HIF-1 signaling pathway
tod04068
FoxO signaling pathway
tod04071
Sphingolipid signaling pathway
tod04072
Phospholipase D signaling pathway
tod04140
Autophagy - animal
tod04150
mTOR signaling pathway
tod04151
PI3K-Akt signaling pathway
tod04152
AMPK signaling pathway
tod04210
Apoptosis
tod04211
Longevity regulating pathway
tod04213
Longevity regulating pathway - multiple species
tod04218
Cellular senescence
tod04261
Adrenergic signaling in cardiomyocytes
tod04370
VEGF signaling pathway
tod04371
Apelin signaling pathway
tod04380
Osteoclast differentiation
tod04510
Focal adhesion
tod04550
Signaling pathways regulating pluripotency of stem cells
tod04611
Platelet activation
tod04613
Neutrophil extracellular trap formation
tod04620
Toll-like receptor signaling pathway
tod04625
C-type lectin receptor signaling pathway
tod04630
JAK-STAT signaling pathway
tod04660
T cell receptor signaling pathway
tod04662
B cell receptor signaling pathway
tod04664
Fc epsilon RI signaling pathway
tod04666
Fc gamma R-mediated phagocytosis
tod04668
TNF signaling pathway
tod04722
Neurotrophin signaling pathway
tod04725
Cholinergic synapse
tod04728
Dopaminergic synapse
tod04810
Regulation of actin cytoskeleton
tod04910
Insulin signaling pathway
tod04914
Progesterone-mediated oocyte maturation
tod04915
Estrogen signaling pathway
tod04917
Prolactin signaling pathway
tod04919
Thyroid hormone signaling pathway
tod04920
Adipocytokine signaling pathway
tod04922
Glucagon signaling pathway
tod04923
Regulation of lipolysis in adipocytes
tod04926
Relaxin signaling pathway
tod04929
GnRH secretion
tod04931
Insulin resistance
tod04932
Non-alcoholic fatty liver disease
tod04933
AGE-RAGE signaling pathway in diabetic complications
tod04935
Growth hormone synthesis, secretion and action
tod04936
Alcoholic liver disease
tod04973
Carbohydrate digestion and absorption
tod05010
Alzheimer disease
tod05017
Spinocerebellar ataxia
tod05132
Salmonella infection
tod05135
Yersinia infection
tod05142
Chagas disease
tod05145
Toxoplasmosis
tod05152
Tuberculosis
tod05160
Hepatitis C
tod05161
Hepatitis B
tod05162
Measles
tod05163
Human cytomegalovirus infection
tod05164
Influenza A
tod05165
Human papillomavirus infection
tod05166
Human T-cell leukemia virus 1 infection
tod05167
Kaposi sarcoma-associated herpesvirus infection
tod05168
Herpes simplex virus 1 infection
tod05169
Epstein-Barr virus infection
tod05170
Human immunodeficiency virus 1 infection
tod05200
Pathways in cancer
tod05205
Proteoglycans in cancer
tod05207
Chemical carcinogenesis - receptor activation
tod05208
Chemical carcinogenesis - reactive oxygen species
tod05210
Colorectal cancer
tod05211
Renal cell carcinoma
tod05212
Pancreatic cancer
tod05213
Endometrial cancer
tod05214
Glioma
tod05215
Prostate cancer
tod05218
Melanoma
tod05220
Chronic myeloid leukemia
tod05221
Acute myeloid leukemia
tod05222
Small cell lung cancer
tod05223
Non-small cell lung cancer
tod05224
Breast cancer
tod05225
Hepatocellular carcinoma
tod05226
Gastric cancer
tod05230
Central carbon metabolism in cancer
tod05231
Choline metabolism in cancer
tod05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
tod05415
Diabetic cardiomyopathy
tod05417
Lipid and atherosclerosis
tod05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
tod00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
119249321 (AKT2)
04012 ErbB signaling pathway
119249321 (AKT2)
04014 Ras signaling pathway
119249321 (AKT2)
04015 Rap1 signaling pathway
119249321 (AKT2)
04370 VEGF signaling pathway
119249321 (AKT2)
04371 Apelin signaling pathway
119249321 (AKT2)
04630 JAK-STAT signaling pathway
119249321 (AKT2)
04668 TNF signaling pathway
119249321 (AKT2)
04066 HIF-1 signaling pathway
119249321 (AKT2)
04068 FoxO signaling pathway
119249321 (AKT2)
04072 Phospholipase D signaling pathway
119249321 (AKT2)
04071 Sphingolipid signaling pathway
119249321 (AKT2)
04024 cAMP signaling pathway
119249321 (AKT2)
04022 cGMP-PKG signaling pathway
119249321 (AKT2)
04151 PI3K-Akt signaling pathway
119249321 (AKT2)
04152 AMPK signaling pathway
119249321 (AKT2)
04150 mTOR signaling pathway
119249321 (AKT2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
119249321 (AKT2)
09143 Cell growth and death
04210 Apoptosis
119249321 (AKT2)
04218 Cellular senescence
119249321 (AKT2)
09144 Cellular community - eukaryotes
04510 Focal adhesion
119249321 (AKT2)
04550 Signaling pathways regulating pluripotency of stem cells
119249321 (AKT2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
119249321 (AKT2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
119249321 (AKT2)
04613 Neutrophil extracellular trap formation
119249321 (AKT2)
04620 Toll-like receptor signaling pathway
119249321 (AKT2)
04625 C-type lectin receptor signaling pathway
119249321 (AKT2)
04660 T cell receptor signaling pathway
119249321 (AKT2)
04662 B cell receptor signaling pathway
119249321 (AKT2)
04664 Fc epsilon RI signaling pathway
119249321 (AKT2)
04666 Fc gamma R-mediated phagocytosis
119249321 (AKT2)
04062 Chemokine signaling pathway
119249321 (AKT2)
09152 Endocrine system
04910 Insulin signaling pathway
119249321 (AKT2)
04922 Glucagon signaling pathway
119249321 (AKT2)
04923 Regulation of lipolysis in adipocytes
119249321 (AKT2)
04920 Adipocytokine signaling pathway
119249321 (AKT2)
04929 GnRH secretion
119249321 (AKT2)
04915 Estrogen signaling pathway
119249321 (AKT2)
04914 Progesterone-mediated oocyte maturation
119249321 (AKT2)
04917 Prolactin signaling pathway
119249321 (AKT2)
04926 Relaxin signaling pathway
119249321 (AKT2)
04935 Growth hormone synthesis, secretion and action
119249321 (AKT2)
04919 Thyroid hormone signaling pathway
119249321 (AKT2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
119249321 (AKT2)
09154 Digestive system
04973 Carbohydrate digestion and absorption
119249321 (AKT2)
09156 Nervous system
04725 Cholinergic synapse
119249321 (AKT2)
04728 Dopaminergic synapse
119249321 (AKT2)
04722 Neurotrophin signaling pathway
119249321 (AKT2)
09158 Development and regeneration
04380 Osteoclast differentiation
119249321 (AKT2)
09149 Aging
04211 Longevity regulating pathway
119249321 (AKT2)
04213 Longevity regulating pathway - multiple species
119249321 (AKT2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
119249321 (AKT2)
05205 Proteoglycans in cancer
119249321 (AKT2)
05207 Chemical carcinogenesis - receptor activation
119249321 (AKT2)
05208 Chemical carcinogenesis - reactive oxygen species
119249321 (AKT2)
05230 Central carbon metabolism in cancer
119249321 (AKT2)
05231 Choline metabolism in cancer
119249321 (AKT2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
119249321 (AKT2)
09162 Cancer: specific types
05210 Colorectal cancer
119249321 (AKT2)
05212 Pancreatic cancer
119249321 (AKT2)
05225 Hepatocellular carcinoma
119249321 (AKT2)
05226 Gastric cancer
119249321 (AKT2)
05214 Glioma
119249321 (AKT2)
05221 Acute myeloid leukemia
119249321 (AKT2)
05220 Chronic myeloid leukemia
119249321 (AKT2)
05218 Melanoma
119249321 (AKT2)
05211 Renal cell carcinoma
119249321 (AKT2)
05215 Prostate cancer
119249321 (AKT2)
05213 Endometrial cancer
119249321 (AKT2)
05224 Breast cancer
119249321 (AKT2)
05222 Small cell lung cancer
119249321 (AKT2)
05223 Non-small cell lung cancer
119249321 (AKT2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
119249321 (AKT2)
05170 Human immunodeficiency virus 1 infection
119249321 (AKT2)
05161 Hepatitis B
119249321 (AKT2)
05160 Hepatitis C
119249321 (AKT2)
05164 Influenza A
119249321 (AKT2)
05162 Measles
119249321 (AKT2)
05168 Herpes simplex virus 1 infection
119249321 (AKT2)
05163 Human cytomegalovirus infection
119249321 (AKT2)
05167 Kaposi sarcoma-associated herpesvirus infection
119249321 (AKT2)
05169 Epstein-Barr virus infection
119249321 (AKT2)
05165 Human papillomavirus infection
119249321 (AKT2)
09171 Infectious disease: bacterial
05132 Salmonella infection
119249321 (AKT2)
05135 Yersinia infection
119249321 (AKT2)
05152 Tuberculosis
119249321 (AKT2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
119249321 (AKT2)
05142 Chagas disease
119249321 (AKT2)
09164 Neurodegenerative disease
05010 Alzheimer disease
119249321 (AKT2)
05017 Spinocerebellar ataxia
119249321 (AKT2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
119249321 (AKT2)
05418 Fluid shear stress and atherosclerosis
119249321 (AKT2)
05415 Diabetic cardiomyopathy
119249321 (AKT2)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
119249321 (AKT2)
04932 Non-alcoholic fatty liver disease
119249321 (AKT2)
04931 Insulin resistance
119249321 (AKT2)
04933 AGE-RAGE signaling pathway in diabetic complications
119249321 (AKT2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
119249321 (AKT2)
01524 Platinum drug resistance
119249321 (AKT2)
01522 Endocrine resistance
119249321 (AKT2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
tod01001
]
119249321 (AKT2)
Enzymes [BR:
tod01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
119249321 (AKT2)
Protein kinases [BR:
tod01001
]
Serine/threonine kinases: AGC group
AKT/PKB family
119249321 (AKT2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
PH
Kinase-like
Pkinase_C
PH_20
PH_11
ABC1
Motif
Other DBs
NCBI-GeneID:
119249321
NCBI-ProteinID:
XP_037372465
LinkDB
All DBs
Position
Unknown
AA seq
481 aa
AA seq
DB search
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGEDPM
DYKCGSPSDSSAAEDMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGSLELDQRTHFPQFSYSASIR
E
NT seq
1446 nt
NT seq
+upstream
nt +downstream
nt
atgaacgaagtgtctgtcatcaaagaaggctggctccacaagcgcggtgaatacatcaag
acctggagacctcggtacttcctgctgaaaagtgacggctccttcatcggctacaaggag
cggcctgaggcccccgatcagaccttaccccccctaaacaacttctctgtcgcagagtgc
cagctgatgaagacggagaggccacggcccaacacctttgtcatacgctgcctgcagtgg
accacagtcattgagaggactttccatgtagactctcccgatgagagggaggagtggatg
agggccatccagatggtcgccaacagcctcaagcagcggggcccaggtgaggaccccatg
gactacaagtgtggctcccccagcgactcttctgcagcggaggatatggaagtggcagtt
agtaaagccagggccaaggtgaccatgaatgacttcgactatctcaaactcctgggcaag
ggcacctttggcaaagtcatcctggtgcgggagaaggccaccggccgctactacgccatg
aagatcctgcggaaggaggttatcattgccaaggatgaagttgcccacacggtcaccgag
agccgtgtcctccagaacaccaggcacccgttcctcacggcactgaagtacgccttccag
acccacgaccgcctgtgcttcgtgatggagtacgccaacggtggtgagctgttcttccac
ctgtcccgggagcgcgtcttcacggaggagcgggcccgcttctacggtgcggagatcgtc
tcggccctggagtacctgcactcgagagacgtggtgtatcgagacatcaagctggaaaat
ctcatgctggacaaagatggccacatcaagatcactgactttggcctgtgcaaagagggc
atcagtgacggggccactatgaagaccttctgtgggacccccgaatacctggcccctgag
gtgctggaggacaatgattacggccgggccgtggactggtggggcctgggcgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgag
ctcatcctcatggaggagatccgctttccgcgcacgctcagccccgaggcaaagtccttg
ctggctgggctgcttaagaaggaccccaagcagaggctcggcggggggcccagcgatgcc
aaggaggtcatggagcacaggttcttcctcagcatcaactggcaggatgtggttcagaag
aagctcctgccacccttcaagcctcaggtcacatctgaggtcgacacaaggtactttgat
gacgagttcaccgcccagtccatcacaatcacacccccggaccgctatgacagcctgggc
tcccttgaactggaccagcggacccacttcccacagttctcctattcggccagcatccgc
gagtga
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integrated database retrieval system