Tupaia chinensis (Chinese tree shrew): 102480722 Help Entry 102480722         CDS       T02978                                  Symbol KMT2D Name (RefSeq) lysine methyltransferase 2D   KO K09187   [histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354] Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup00310   Lysine degradation tup01100   Metabolic pathways tup04934   Cushing syndrome Brite KEGG Orthology (KO) [BR:tup00001]  09100 Metabolism   09105 Amino acid metabolism    00310 Lysine degradation     102480722 (KMT2D)  09160 Human Diseases   09167 Endocrine and metabolic disease    04934 Cushing syndrome     102480722 (KMT2D)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:tup03036]     102480722 (KMT2D) Enzymes [BR:tup01000]  2. Transferases   2.1  Transferring one-carbon groups    2.1.1  Methyltransferases     2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase      102480722 (KMT2D) Chromosome and associated proteins [BR:tup03036]  Eukaryotic type   Histone modification proteins    HMTs (histone methyltransferases)     HKMTs (histone lysine methyltransferases)      102480722 (KMT2D)    HMT complexes     MLL-HCF complex      102480722 (KMT2D) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PHD SET FYRN FYRC zf-HC5HC2H zf-HC5HC2H_2 HMG_box Motif Other DBs NCBI-GeneID:  102480722 NCBI-ProteinID:  XP_006168299 LinkDB All DBs Position Un AA seq 5530 aa AA seqDB search MDSQKPPGEDKDSEPAADGPAASEESGTTEPDLPNPHVGEVSASSSGSPRLQEPPRDCSG GPVRRCALCNCGEPSLHGQRELRRFELPFDWPRCPVVSPGGSPGPNEAVLPSEDLSQIGF PEGLTPAHLGQPGGSCWAHHWCAAWSAGVWGQEGPELCGVDKAIFSGISQRCSHCTRLGA SIPCRSPGCPRLYHFPCATASGSFLSMKTLQLLCPEHSEGAAHLEEARCAVCEGPGELCD LFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACRKPGNDSKMLVCEMCDKGYHT FCLKPPMEELPAHSWKCKACRVCRACGVGSAELDPNSEWFENYSLCHRCHQAQGGQPMSS VAEQHPSVCSRFSPPEPGGTPTDEPDALYVACQGQPKGGRVTSMQPKEPGPLQCEAKPLG RAVAQLEPQLLAPLNEEMPLPPPPEESPLSPPPEESPTSPPPEASRLSPPPEESPASPPP EASHLSPLPEESPLSPPPEESPLSPPLESSPFSPLEESPPSPALEIPLSPPPEASPLSPP FEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPL SPPPEESPLSPPPEASRLSPPPEDSPMSPPPEDSPMSPPPEVSCLCPLPEVSHLSSLPEV SRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSLTSPPPEDSLVSLP LEEESPLSPLPEELHLCPCPEEPHLSPQPEEPHLSPVLEEPCLSSGPEKLHLSPQYEEPC LLPQPEELHLSPHREGPHLSPQPEGLHLSPRCEGLHLSPRPEGLHLSPRREGPHLSPQPE GQHLAPRCEGPHLSPRPEEPHLSPWPEDPHVSPRPEEPRLSPRPEELCLSPRPEELHLSP RPQEPHLSPVAEEPHLSPGPKEPCLSPQPEEPPEESGQCPAPKELPLLPPPGEPPSSPLL GEPALSEPGEPPLSPLPEELPLSPSGEPFLSPQPMPPDPLPPPLSPIITAVAPPALSPLG ELEYPFGAKGDSDPESPLPAPILETPISPPPEANCTDPEPVPPMILPPSPGSPMGPTSPI LMEPLPPQCSPLLQHTLPPQNSPPSQCSPPALPLSMPSPLSPIGKALEVPDEAEPHEMET EKVPEPECPALEPSATSPLPSLMGDLSCPAPVLDDFSGLGEDTAPLDGTDAPGSQPESGQ TPGSLASELKGSPVLLDPEELAPVTPMEVYGPECKQAGQGSPCEEQEEPRPPVAPTPPTL IKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGISTDVSPARDEGSLRL CTDSLPETDDSLLCDTGTAISGGKAEGDKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAH GGRGRGRARLKSTTSSIETLVVADIDSSPSKEEEEDDDDTMQNTVVLFSNTDKFVLMQDM CVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDP SRLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCG PCASLVTCPICHAPYVEEDLLIQCRHCERWMHAGCESLFTEDDVEQAADEGFDCVSCQPY VVKPVAPIAPPELVPMKVKEPEPQYFRFEGVWLTETGMAVLRNLTMSPLHKRRQRRGRLG LPGEAGLEGSEPSDALGPDDKKDGDLDTEELLKGEGGVEHMECEIKLEGPVSPDVEPGKE ETEESKKRKRKPYRPGIGGFMVRQRKSHTRLKRGPAAVQAEVLSGDGQPDEVMPTDLPAE GSVEPSVVDGDEKKKQQRRGRKKNKLEDMFPAYLQEAFFGKELLDLSRKALFAVGVGRPS FGLGTSKPKGDGGSDRKEPPTSQKGDDGPDVADEESRGPEGKADTPGPEDGGIKASPVPS DPEKPGTPGEGMLSSDLDRIPTEELPKMESKDLQQLFKDVLGSEREQHLGCGTPSLEGSR TPLQRPFLQGGLPLSNLPSSSPMDYPSLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGT TPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANINFPNLKQDYPDWS SRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDIARKTDR PALHLRIPPQPGALGSPPPAAAPTIFIPTLSMAAPPPPAGLSTSADGFLKPPVGTVPGPD SPGELFLKLPPQVPAQVPSQDPFGLAPAYALEPRFPTAPPSYPPYPSPTGAPVQPPMLST SSRAGTGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLS PPPFGESRKALEVKKEELRASSPSYGPPNLGFVDSPSSGPHLGGLELKAPDVFKAPLTPR ASQVEPQSPGLGLRPQEPPPAQALAPSSPSHSDIFRPGPYPDPYAQPPSTPRPQPPPSES CCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPP SRPQSRDPFAPLHKPPRPQPPEVAFKAGPLAHTPLGAAGFPAALPSGPAGELHAKVPSGQ PPNFARSPGTGAFVGTPSPMRFTFPQVVGEPSLKPPLPQPGLPPPHGINSHFGPGPTLAK PQSTNYTVATGSFHPSGSPLGPSSGPTGEGYGLSPLRPPSVLPPPAPDGSLPYLSHGAPQ RAGITSPVEKREDPGTGMGSSLAASELPATQDPGMSSLSQTELEKQRQRQRLRELLIRQQ IQRNTLRQEKETAAAAAGAVAPPGSWGAEPSSPAFEQLSRGQTPFVGTQDKSSLVGLPPG KLGGPILGPGSFPSHDRLSRPPPPATPSSTDVSSRQLVGGSQAFYQRAPYPGSLPLQQQQ QQQLWQQQQQQQATAATSMRLAMSTRFPSTAGPELGRQALGSPLAGIPTRLPGPGEPVPG PAGPAQFIELRHNVQKGLGPGGAPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSGLP PQKPSAPPAPELSNSLHPTVHTKGPTLPTGLELVNRPPSSTEFSRPPPLALEAGKLPCED PELDDDFDAHKALEDDEELAHLSLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDLL AYTDPELDTGDKKDIFNEHLRLVESANEKAEREALLRGVEPGSLGPEERPPPVADASEHR LASVLPEVKPKVEEGGRHPSPCQFTITTPKVEPASATTSLSLGLKPGQTVMGSRDTRMGA GPFSSSGHTAEKGPFGATGGTSAHLLTPSPLSGQGGSSLLEKFELESGALTLPGGHAAPG DELDKMESSLVASELPLLIEDLLEHEKKELQKKQQLSTQLQPSQQQQQQQQQSSGHHSLL ATPGPAQALPLTHEGSSPSLAGPQQQLSLGLGGTRPPGLAQPLLPTQPPAHALQQRLTPS MAMVSNQGHMLSGQHGSQAGLVPQQNPQPVLAQKPMGTMPPSMCMKPQQLAMQQQLANSF FPDTDLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGT GSDLQNHVAAGSGQERSAGDPSQPRPNPPTFAQGMINEADQRQYEEWLFHTQQLLQMQLK VLEEQIGVHRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQK EHTNLMAEYRNKQQQQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPP GGQAGGLRLPPGGMALSGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGFFPGNLALRS LGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQQQQQQHLLGQVAIQQQQQQGPGI QANQALGPKAQGLLPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALAPQGP HRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTTQQQQQQQHQQQGSMAGLSHLQQGLMSHS GQPKLSAQPMGSLQQQQLQQQHQQQQVTLGPGMPAKPLQHFSSPGALGPSLLLTGKEQNV VETTLPSEVTEGPSTHQGGPLAIGSTPESVATEPGEVKPSLSGDSQLLLVQPQAQPQSNS LQLQTPLRPPGQQQQQVNLLHTAGVGSHGQLGSGPSSETSSMSHLLVPPSVSLGEQPGPV NQNLLGPQQPIGLERPMQNNAGPQPPKSGPIPQSGHGLTGTGVMPTVGQLRAQLQGVLAK NPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGAQPSPLQGLLGCHSQLGGFP GTQTGPLQELGVGPRPQGPPRLPAPHGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPS SQLPTEAQFPPTHPGTPKPQGPPLELPSGRVSPAAAQLADTFFGKGLGPWDPPDNLAEAQ KPEQSSMVPGHLEQVNGQVVSEPPQLSIKQEPREEPCALGAQAVKREANGEPIGAPGTSN HLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGPEGLRAEINGHIDSKLAGLEQKLQGTPS NKEDAAARKPLTPKPKRVQKASDRLMSSRKKLRKEDGVRASEALLKQLKQELSLLPLTEP TITANFSLFAPFGSGCPISGQSERRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSLP PTPPPSVQQKMVNGVTPSEELGEHPKDAAPARDTEGALRDASEVKSLDLLAALPTPPHNQ TEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPQLGSGRWEQDDRALSPVIPIIPRA SIPVFPDTKPFGALDLEVPGKLPATTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELL SMKIPNSYEVLFPENATRPGMEPKKGEAEGPGGKEKGLESKSPDTGPDWLKQFDAVLPGY TLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPAS PPAEPLVELPAEPSTEPPVPSPLPLASSPESTRSKPRARPPEEGEDSRPPRLKKWKGVRW KRLRLLLTIQKGSGRQEDEREVAEFMEQLGTALRPDKVPRDMRRCCFCHEEGDGATDGPA RLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGATSSCNRM RCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSFAVFRRVYIERDEVKQIAS IIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRRCC YRCSIGENNGRPEFVIKVIEQGLEDLVFTDASPQGXXXRFLAPWAAMRKEADMLRLFPEY LKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPKILT HYKRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVYLARSRIQ GLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTG GPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHC GAWNCRKWMN NT seq 16593 nt NT seq  +upstreamnt  +downstreamnt atggacagccagaagccgcctggtgaggataaagattcagaaccggcagctgatggacct gcagcctctgaggagtcaggcaccactgagccagaccttcccaacccacatgtgggggag gtttctgcctccagttctgggagtcccaggcttcaggagcctccccgggactgcagtggg ggtccagtgcggcgttgtgctctctgtaactgcggggagcccagtctgcatgggcagcgg gagctacggcgctttgagttgccatttgactggccccggtgtccagtggtgtcccctggg gggagcccagggcccaatgaggcagtgctgcccagtgaggacctatcacagattggtttc cctgagggccttacacctgcccacctaggacaacctggagggtcctgctgggctcaccat tggtgtgctgcatggtccgcaggcgtatgggggcaggagggcccagaactatgtggtgtg gacaaggccatcttctcagggatctcacagcgctgctcccactgcaccaggctcggtgcc tccatcccttgccgctcgcccggatgtccacgtctttaccatttcccctgtgcgactgcc agcggttccttcttatccatgaaaacgctgcagctgctatgcccggagcacagtgagggg gctgcacatctggaggaggctcgctgtgcagtgtgcgaggggccaggggaattgtgtgac ctgttcttttgtaccagctgtgggcatcactaccacggggcctgcctggacactgctctg actgcccgcaaacgtgctggctggcagtgccctgagtgtaaagtgtgccaagcttgcagg aaacctgggaatgactctaagatgttggtctgtgagatgtgtgacaaagggtaccatacc ttttgcctgaaaccacccatggaggagctgcctgctcactcttggaagtgtaaggcatgc cgggtatgccgggcctgtggggtaggctcagcagaactggatcccaattctgagtggttt gagaactactcactttgtcaccgctgtcaccaagcccagggaggtcagcctatgagttct gttgctgagcagcacccctctgtctgtagcagattttcacccccagagcctggcggtaca cccactgatgagcccgatgctctgtacgttgcatgccaagggcagccaaagggtgggcgc gtgacctctatgcaacccaaggaaccggggcccctgcaatgtgaagccaaaccactaggg agagcagtggcccaacttgaaccccaattgctggcccccctaaacgaggagatgccactg ccgcccccacctgaggagtcgcctctgtccccaccacctgaagaatcacccacatcccca ccgccggaggcatcacgcttgtccccaccacctgaggaatcacctgcatctccgccacct gaggcatcgcatctgtccccgctgcctgaggagtcgcctctttctcctccacctgaggag tctcctctgtctcccccacttgaatcatcgcctttttctccactagaggagtcgccccca tctcccgcacttgagattcctttgtcccccccacctgaagcatcacccctgtccccacca tttgaagagtctcccttgtcccctccacctgaggaattgcctacttccccaccgcctgaa gcatctcgcctgtctccaccacctgaggagtcacccatgtctccgccacctgaggagtca cccatgtctccgccacctgaggcatctcgtcttttcccaccatttgaagagtctcccctg tcccctccgcctgaggagtctcccctctccccaccaccagaggcatcgcgcctgtcccca cctcctgaagactcacccatgtccccaccacctgaagactcacctatgtcccccccaccg gaggtatcatgcctgtgccctctgcctgaggtgtcacacttatcctccctgcctgaggtg tcacgtttgtccccaccccctgaggaatctcccctgtccccaccacctgaggagtctccc acctcccctccacctgaggcttcacgcttatcgcccccacctgaagactcgcccacatcc ccaccacctgaagactctctcacttccccaccaccggaggactcgcttgtgtctctgccg ctggaggaggagtcacctctgtcaccactgcctgaggagctacatctctgcccctgcccc gaggagccgcacctgtcaccccagcctgaggagccacatctgtcccctgtgcttgaggag ccatgtctgtcctcagggcctgagaagctgcacctgtcccctcagtacgaggagccatgc ttgttgccccaacctgaggaactgcacctgtccccccatcgtgagggaccgcacctgtct ccccagcctgagggactgcacctgtcccccaggtgtgagggactgcatctgtccccccgg cctgagggactgcacctgtctccgcggcgcgagggaccgcacctgtccccccagcctgag ggacagcatctggccccccggtgtgagggacctcatctgtccccccggcctgaggaaccg cacctgtctccgtggcctgaggacccgcacgtgtccccccggcctgaggaaccacgcctg tccccccggcctgaggaactatgcctgtccccccggcctgaggaactgcacctgtcccct cggcctcaggagccacatctgtcccccgtggctgaggaaccacacctatctcctggacct aaggagccttgcctatcccctcagcctgaagagccccctgaagagtcaggccaatgccct gcacctaaggagctgcccttgctccctccacccggggagccaccctcatcccccttgctt ggagagccggccctgtctgagcctggggaaccacctctgtcccctctgcctgaggagctg cccctgtccccatctggggagccattcttgtcacctcagccgatgccaccagatcctctt cctcctccgctctcacccatcatcacagctgtggctccgcctgccctgtctcctttgggg gagttagagtacccctttggtgccaaaggggacagtgaccccgagtcaccattgcctgcc cctattctcgagacacccatcagtcctccaccagaagctaattgcactgaccctgagcct gtaccccctatgatccttcccccatctccaggctccccaatgggaccgacttctcccatt ctgatggagccccttccccctcagtgttctccactccttcagcataccctacctccccaa aactcccctccttcccagtgctcccctcctgctctgccactgtccatgccctccccgttg agtcccatagggaaggcattggaagtcccagatgaggctgagccacatgagatggagact gagaaagttccagaacctgagtgcccagccttagaacccagtgccaccagtcctctccct tccctcatgggtgacctttcctgtcctgccccagtcctggatgacttctctggcttgggg gaagacacagcccctctggatgggactgatgcacctggttcacagccagaatctggacag acccctggcagtctggctagtgaacttaaaggttcccctgtgctcctggaccccgaggag ctggcccctgtgacccctatggaggtctatggtccagagtgcaagcaggcagggcagggc tcaccctgtgaagaacaggaggagccacgtccaccagtggcccccacgccacctactctg atcaaatccgacatcgttaatgagatctctaatctgagccagggtgatgccagtgccagt tttcctggctcagagcccttgctgggctctcctgaccctgaggggggcggctccctgtcc atggagctggggatatctacagacgtcagccccgcccgagatgagggctcactgcggctt tgtaccgattcgctgccggagacagatgactcgctgttgtgtgacactgggacagctatc agtggaggcaaagccgagggggacaaggggaggcggcgcagctccccagctcgttcacga atcaaacagggtcgcagcagtagtttcccaggaagacgccggcctcgtgggggagcacat ggaggacgtgggagaggacgggcccgcctaaaatcaactacttcttccattgaaactctg gtagttgctgatatcgatagttctcctagcaaggaggaggaagaagatgatgatgacacc atgcaaaataccgtcgttctcttctccaacacagacaagtttgtcctaatgcaggacatg tgtgtggtgtgtggcagcttcggcaggggggcagagggccacctgctcgcctgttcgcag tgttctcagtgctatcacccttactgtgtcaacagcaagatcaccaaggtgatgctgctc aagggctggcgttgtgtggagtgtattgtgtgtgaggtgtgtggccaggcctccgacccc tcccgcctgctgctctgtgatgactgtgacatcagctaccacacatactgcctggatccc ccgctgctcaccgtgcccaagggcggctggaagtgcaagtggtgtgtgtcttgtatgcag tgtggggccgcctcccctggcttccactgtgagtggcagaatagttacacacactgtggg ccctgcgccagcctggtgacctgccctatctgtcatgccccgtacgtggaagaggacctg ctgatccagtgccgccactgtgaacggtggatgcatgctggctgtgagagcctcttcaca gaggatgatgtggagcaagctgctgatgagggctttgactgtgtctcctgccagccttac gtggtaaagcctgtggcacctattgcgcctccagagttggtgcctatgaaagtgaaagag ccagagcctcagtactttcgcttcgagggtgtgtggttgacagaaactggcatggccgtg ctgcgtaacctgaccatgtcaccactgcacaagcggcgacagcggcgaggacggcttggc ctcccaggcgaggcagggctggagggttccgagccctcagatgcccttggccctgatgat aagaaggatggggacctggacaccgaagaactgcttaagggtgaaggtggggtagagcac atggagtgtgaaattaaactggagggtcccgtcagccctgatgtggagcctggtaaagag gagactgaggaaagcaagaaacgcaagcgtaaaccctaccggcctggcattggtggtttc atggtgcgacagcggaagtcccacacacgcctgaagagggggcctgctgctgtccaggcg gaagtgttgagtggggatgggcagcccgacgaggtgatgccgactgatctgcctgcagag ggctccgtggagccgagcgtggttgatggggatgagaagaagaagcagcagcggaggggg cgcaagaagaataaactggaggacatgttccctgcctatctgcaggaagctttctttgga aaggagttgctggacttgagccgtaaggccctgtttgcagttggagtaggtcggccaagc tttggactaggcacctccaaacccaagggggatggaggctcagataggaaggagcccccc acatcacagaaaggagatgatggtccagatgttgcagatgaagagtcccgtggccctgag ggcaaggctgacacaccaggacctgaggacgggggcataaaggcatccccagtacccagt gaccctgagaagccaggcaccccaggtgaagggatgcttagctctgacttagacaggatt cccacagaagaactgcccaagatggaatccaaggacctgcagcagctcttcaaggatgtt ctgggttctgaacgagagcagcacctgggctgcggaacccccagcctagaaggcagccgc acaccactgcagaggccctttctccaaggtggactccctttgagcaatctcccttccagc agcccaatggactacccgagcctctgccagtccccattcctggattctagggagcgcggg ggcttctttagcccggaacccggtgagccagacagcccctggacaggctcagggggcacc acgccctccacccccaccacccctaccacagagggtgagggcgatggactctcctataac cagcggagccttcagcgctgggagaaggacgaggagttgggccagctgtccaccatctca cctgtgctctatgccaacattaactttcccaatctcaagcaagattacccagactggtcc agtcgttgcaaacaaatcatgaaactctggagaaaggtgccggccgccgacaaagcccct tacctgcaaaaggccaaagataaccgggcggctcaccgcattaacaaggtgcagaagcag gctgagagccagatcaacaagcagaccaaggtgggcgacatagcccgcaagactgaccga ccagccctgcatctccgcattcccccccagccaggggcactgggcagtccgccccctgct gctgcccccaccattttcattcccacactttccatggccgccccccctccccccgccggc ttgtctacctctgcggacgggttcttgaagccgccggtgggcacagtgcccggccccgac tcgcctggtgagctcttcctcaagctcccgccccaggtgcccgcccaagtgccttcgcag gacccctttggactggctcccgcctatgccctggagccccgcttccccactgcaccaccc agctatcccccctatcctagtccaactggggcccctgtgcagcccccgatgctgagcacc tcatctcgtgctgggactggccagccaggggaatttcacaccacgccacctggcaccccc cgacaccagccctccacacctgaccccttcctcaaaccccgctgcccctcattggacaac ctggctgtgcctgagagcccaggggtagggggaggcaaagcttctgagcccctgctttcg cccccgccttttggggagtcccggaaggccctagaggtgaagaaagaagagcttagagcc tcctctcctagctatggacccccaaacctgggctttgttgactcaccctcctctggcccc catcttggtggcctggagttaaaggcacctgatgtcttcaaagctcccctgacccctcgg gcatctcaggtagaaccccagagcccgggcttgggccttcggccccaggagccacccccc gcccaggctttggccccttcttcccccagccattctgacatcttccgccctggcccctat cctgacccctatgctcagcccccctcgacccctcggcctcagcccccaccctctgagagc tgctgtgccctgccccctcgctcactgccctctgaccctttctccagagtgcccgccagt cctcagtcccagtctagctcccagtctccattgacaccccgtcctttgtctgctgaggct ttctgcccatctccagttacccctcgcttccagtccccagacccttactctcgtccccct tcacgccctcagtcccgtgacccatttgctccattacataagccacctcgaccccagccc cctgaagttgcctttaaggctgggcctttagcccacactccactaggggctgcgggtttc ccagcagccctgccctcagggccagcaggtgagctccatgccaaggtccccagcgggcag ccccccaattttgcccggtcccctgggacaggtgcatttgtgggcaccccttctcccatg cgtttcaccttccctcaggtagtaggggagccttccctaaagccccctcttcctcaacct ggtctccctccaccccatgggatcaacagccattttgggcccggccccaccttggccaag cctcaaagcacaaactacacagtagccacagggagtttccacccgtcgggcagccccctg ggacccagcagtgggcccactggggagggctatgggctgtccccactacgtcccccatcg gttctgccaccacctgcacccgacggatccctcccctacctgtcccatggagccccacag cgggcaggcatcacctctccagttgaaaagcgagaagacccagggactggaatgggtagt tctttggcggcatctgaactcccggctacccaggacccaggcatgtccagccttagtcag acagagctggagaagcagcggcagcgccagcgactacgggagctgctgattcggcagcag atccagcgcaacaccctgcggcaagagaaggaaacagctgcagcagctgcaggagcagtg gcaccccccggcagctggggtgctgagcccagcagccctgcctttgagcagctgagtcga ggccagaccccctttgttgggacccaggacaaaagcagccttgtgggtttgcccccaggc aagctgggcggccccatcttagggccggggtcctttcccagccatgaccgactttcccgg ccacctccgccagctacaccttcctctacggatgtgagcagccggcaactggtaggaggc tcccaagccttctatcagcgagcaccctatcctggatccctgcccttacagcagcaacag cagcaacaactgtggcagcagcagcagcagcagcaagcaacagcagcaacctctatgcgc cttgccatgtctactcgctttccatcaactgctggacctgaacttggccgccaagcccta ggttcccccttggcgggaattcccacccgcctgccaggccctggtgagccagtacctggt ccagctggtcctgcccagttcattgagttgcggcacaatgtacagaaaggactaggacct ggaggggctccatttcctggtcaaggcccccctcagagaccccgtttttatcctgtaagt gaggacccccaccgactggctcctgaagggcttcggggcctggcagtatcgggtcttccc ccacagaaaccttcagccccaccagcacctgagttgagcaacagccttcatccgacggtc cacaccaagggtcccactctgccaactggcttggaactagtcaaccggccaccctcaagc actgagtttagccgcccccctcctctggccctggaagctgggaagttaccctgtgaggat cctgagctggacgatgactttgatgcccacaaggccctagaggatgatgaagagcttgct cacctgagtctgggtgtggatgtggccaagggggatgatgagctggggaccctagaaaat ctggaaaccaatgatccccacctagatgacctgctcaatggagatgagtttgacctgctg gcctacactgaccctgagctggatactggggacaagaaggacatcttcaatgagcacctg aggctagtggagtctgctaacgagaaggctgagcgggaggccttgctgcggggagtggag ccaggatccttgggccctgaggagcgtcctccccctgttgctgatgcctctgagcatcgc ctggcatctgtgctccctgaggtgaaacccaaggtggaagagggtggacgccatccttcc ccttgccagttcactatcactaccccaaaagtagagccagcatctgctactacttccctc agcctggggctgaaaccaggacagactgtgatgggtagccgggacacccggatgggtgca gggccattttccagcagtggacacacagctgagaagggcccctttggggccacaggagga acatcagctcacctactgactcctagccccctgagtggccaaggaggatcatccttgcta gaaaagtttgagctggagagtggggccctgactttgcctgggggacatgcagcacctggg gatgaactggacaagatggagagctcactggtagccagtgagttgcccctgctcattgag gacctgttggaacatgagaagaaggagctgcagaagaagcagcagctttccacacagctg cagccttcccagcagcagcagcagcagcagcagcagagcagcgggcatcattccctactg gctacaccaggtcctgcccaggcactgcctttgacacatgaaggctcttctcccagtctg gctggacctcaacagcagctttctctgggtcttggaggtactcgaccgccaggcttggct cagccattgctgcccacccagccaccagctcatgccctccagcagcgcctgaccccctcc atggctatggtgtccaaccaagggcatatgctcagtgggcagcatgggagccaggcaggg ttagtgccccagcagaacccacagccagtgctagcacagaagcccatgggcaccatgcca ccctccatgtgcatgaagccccaacagctggcgatgcagcagcagctggctaacagcttc ttcccagatacagacctggacaaatttgctgcagaagatatcattgatcccattgcaaag gccaagatggtggctttgaaaggcatcaagaaagtgatggctcagggcagcattggagtg gcacctggtatgaataggcagcaagtgtccctgctagcccagaggctctcgggaggaact ggtagtgatctacagaaccatgtggcagcaggcagtggccaggagcggagtgccggtgac ccctcccagcctcgtcctaacccacccacttttgcccagggaatgatcaatgaggctgac cagcggcagtatgaggaatggctcttccacacacaacagctcctacagatgcagctgaag gtgttggaagaacagattggtgtgcaccgcaagtcacggaaggctctgtgtgcaaagcag cgcactgccaaaaaggctggccgtgagttccctgaagctgatgccgagaagctcaagctg gttacagagcagcagagtaagatccagaaacagctggaccaggtccggaaacaacagaag gagcacactaatctcatggcagaatatcggaataaacagcagcagcaacagcagcagcaa caacagcaacagcattctgccgtgctggctctcagcccttcccagagtccccggttactc accaaactccctggtcagctgctacctggccatgggctacagccaccacaggggcccccg ggtgggcaagctggaggtcttcgcctgccccctgggggtatggcactatctggacagcct ggtggcccttttctcaacacggccttggcccaacagcagcaacagcaacattctggtggg gctggatccctggctggcccctcagggggcttcttccctggcaaccttgctcttcgaagt cttgggcctgattcaaggcttttacaggaaaggcaactgcagttgcaacagcaacgcatg cagctggcccagaaattgcagcaacaacagcaacagcagcagcagcaacagcagcaacaa cagcagcacctcctaggacaggtggcaatccagcagcaacagcagcagggtcctgggata caggcaaatcaggctctgggtcctaaggcccaaggacttctgcctcccagcagccaccag ggcctcctggtccagcagctgtcccctcaaccaccccaggggccccagggtatgctgggc cctgcccaggtggcagtgttgcagcagcagcaccctggagctttggccccccagggccct cacagacaggtgcttatgacccagtcccgggtgctgagttccccccagctggcgcagcag ggtcagggccttatgggacaccggctggtcacaactcagcagcagcaacaacaacagcac caacagcagggatccatggcagggctttcccatcttcaacagggtctgatgtcacacagt gggcaacccaaactgagcgctcagcccatgggctccttacagcagcaacagcttcagcag cagcaccagcagcagcaggtgacacttggccctggcatgccagccaaacctcttcaacac ttttctagccccggagccctgggcccaagcctcctcctgacgggcaaggagcagaatgtt gtagagacgacccttccttcagaggtcactgaggggccctcaacacatcagggagggcca ttagcaataggatctacacctgagtcagtggccactgaaccaggggaggtaaagccctca ctctctggagactcacaactcctgcttgtccaaccccaggctcagcctcagtccaactct ctgcaactgcagacacctctgaggcccccaggacaacagcagcagcaagttaatttgctc cacacagcaggtgtgggaagccacgggcaactaggcagtggaccatcttcagagacctca tctatgtcccacctgctggtcccaccctctgtttccttaggggagcagcctggacctgtg aatcagaaccttttggggccccaacagcccattgggcttgaacgacccatgcagaataat gcagggccacagcctcccaaatcaggacctattcctcagtctgggcatggtctaactggg actggagtcatgcctacagtgggtcaacttcgagcacagctacagggagtcttggccaaa aacccacagctgcggcacttgagtccgcagcagcagcagcagctacaggcactcctcatg cagcggcagctgcaacagagtcaggcagtacgccagaccccaccctaccaggagcctggg gcccagccctctcccctccagggcctcctaggttgccattctcaacttgggggcttccct ggaacccagacaggtcccctccaggagctaggggtggggcctcgacctcagggcccaccc cggcttcctgccccacacggagccttatctacaggaccagtccttggccctgttcacccc acacctccaccatccagcccacaagagccaaagagaccttcacagttaccttcccctagc tctcagctccccactgaggcccaattccccccaacccatccagggaccccaaagccccag gggccacccttggagctgccttctgggcgggtctcacctgctgctgctcagcttgcggat accttctttggcaaggggttgggaccttgggaccccccagacaacctggcagaagcccag aagccagaacagagcagcatggtacctgggcatctggagcaagtgaatggacaggtggta tctgaaccaccccaactcagcatcaagcaggagccgcgagaagaaccatgtgccctggga gcccaggcggtgaagagggaggccaatggggagccaataggggcaccaggtaccagcaac cacctcctgctggcaggtccccgctcagaggctgggcatctgctcttacagaagcttcta cgggcaaagaatgttcaactcagcactgggcgggggcctgaggggctgcgagctgagatc aacgggcacattgacagcaagctggctgggctggagcagaagctacagggcacccccagc aacaaggaggatgcagcagcaaggaagcctttgacaccaaagcccaagcgggtacagaag gcaagcgacaggttgatgagctcccgaaagaagctgcggaaggaggacggggtcagggcc agcgaggccttgctcaaacagctgaaacaggagctgtccctgctgcccctaacggagcct accatcacggccaattttagcctctttgctccctttggcagtggctgcccgatcagtggg cagagcgagcggaggggggcctttggaagtggggcgctacccactggccctgactactat tcccagctgcttaccaagaataacctgagtaacccgccgacaccaccctcgtcgctgccc cccaccccacccccatcggtgcagcagaagatggtgaatggcgtcactccatctgaagag ctgggggagcaccccaaggatgccgcccctgctcgggatacagagggggcactgagggat gcttcagaggtaaagagtctagacctgctggctgccttgcccacaccccctcacaatcag actgaagatgtcaggatggagagtgacgaggacagcgattctcctgacagtattgtacca gcttcatcccctgaaagcatcttgggggaggaggcccctcgttttcctcagctgggctca ggccggtgggaacaggatgaccgagccctctcccctgtcatccccatcattcctcgggcc agtatcccagtttttccagataccaaaccttttggggcccttgacttggaagtccctgga aagctgcctgccacaacttgggaaaaaggcaaaggaagtgaggtgtcagtcatgttgacg gtctctgctgctgcagccaagaacctgaatggtgtgatggtggcagtggcagagctgctg agcatgaagatccccaactcctatgaggtgctgttcccagagaatgccacccgaccaggc atggaacctaagaagggggaagctgagggccctggtggaaaagaaaagggcctggaaagc aagagcccagacactggccctgattggttgaagcagtttgatgcagtgttgcctggctat actctcaagagccagcttgacatcttgagcctcctgaaacaggagagccccgccccagag ccacctacccagcatagctacacctacaatgtctccaatctggatgtgagacagctctct gctccgcctcctgaagaaccctccccgcccccatcccccttggcaccctctcctgccagt ccccctgctgagcctctggttgaacttccggctgaaccctcaactgagccaccagtcccc tcacctctgccattggcctcatcccctgaatctacccggtccaagccccgagctcggccc ccagaagaaggagaagattcccgtccccctcgcctcaaaaagtggaaaggggtgcgctgg aaacggctgcggctactactgaccatccagaagggcagtgggcggcaggaggatgagcgg gaagtagcagagttcatggagcagcttggaacagccttgcgaccagacaaggtgcctcga gacatgcggcgttgttgcttctgtcatgaagaaggtgatggggccacggatggacctgcc cgcctgctgaacctggacctggacctatgggtgcacctcaactgtgccttgtggtccacg gaggtgtacgagacccagggtggggcactgatgaatgtagaggttgctctgcaccgagga ctgctaaccaagtgttccctgtgccagcgaactggtgccaccagcagctgcaatcgcatg cgttgccccaatgtctaccattttgcctgtgccattcgcgccaaatgcatgttctttaag gacaagaccatgctgtgtccaatgcataaaatcaaggggccctgtgagcaggagctgagc tcttttgctgtcttccggcgggtctacatcgagcgggacgaggtgaagcagatcgccagc atcatccagcggggagaacggttgcacatgttccgggtggggggccttgtgttccatgcc atcggacaactgcttcctcaccagatggccgacttccatagtgccactgccctctatcct gttggctatgaagccacacgcatttactggagcctccgcaccaacaatcgtcgctgctgc taccgctgctccattggcgagaacaacgggcggccagagtttgtaatcaaagtcatcgag cagggcctggaggatctggtcttcactgatgcctctccccagggnnnnnnnnntcgtttc ttggccccttgggctgccatgagaaaagaggccgatatgctgcggctcttccctgagtac ctgaaaggcgaggagctcttcgggctgacggtgcatgctgtgcttcgcatagctgaatca ctgcctggggtggagagttgtcaaaactatttatttcgctatgggcgccaccctctgatg gagctgccactcatgatcaaccccactggctgtgcccgatcggagcctaaaatcctcaca cactacaaacggccccataccctgaacagcaccagcatgtctaaggcatatcagagcacc ttcacaggcgagaccaacaccccgtacagcaagcagtttgtgcactccaagtcatcccag taccgccggctacgcaccgagtggaagaacaacgtgtatctggctcgctcccggattcag ggcctggggctctatgcagccaaggacctagaaaagcacacgatggtcatcgagtacatt ggcaccatcattcgcaatgaagtagctaaccggcgggagaaaatctatgaagagcagaat cgaggcatctacatgttccgaataaacaatgagcatgtgattgatgctacattgactgga ggccctgccaggtacattaaccattcctgtgcccccaactgcgtagcagaagttgtgact tttgacaaggaggacaaaatcatcatcatctccagccggcgaatccccaaaggagaagag ctgacctatgactatcagtttgattttgaggacgatcagcacaagatcccctgtcactgt ggagcctggaattgtcgaaaatggatgaactaa

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